The present communication owns to address the mathematical framework of two-dimensional electrically conductive and thermally radiative Jeffrey nanofluid flow by a curved surface. The interaction of a periodic magnetic field with the suspended nanoparticles and mixed convection are critically important due to its application in a broad spectrum. Buongiorno’s model, incorporates the effect of thermophoretic force and Brownian movement, describes the nature of Jeffrey nanofluid. The influence of activation energy, viscous dissipation, and thermal radiation effects are reserved. The dimensionless system of differential equations has been diminished from the modeled equations via transformation framework which is solved analytically versus homotopic algorithm. The stability and convergence analysis has been carried out to optimize system parameters and accuracy of the system. The effect of physical constraints on flow field, energy, and concentration of nanoparticles are portrayed via plotted graphs and debated.