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Research article
Shaoqiang Huang
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0515-8099
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Background: Previous studies have shown that patients with long-term diabetes require more opioids after surgery than patients without diabetes. Gestational diabetes mellitus (GDM) normally only lasts for a brief period; nevertheless, its effect on sufentanil consumption after cesarean section is unknown.
Methods: This prospective cohort study included two groups: a GDM group (n=32) and a matched non-GDM (NGDM) group (n=32). All patients underwent routine combined spinal-epidural anesthesia for cesarean delivery. Sufentanil consumption through an intravenous patient-controlled analgesia (PCA) pump, the frequency of PCA requests, and visual analog scale (VAS) scores 6 and 24 hours after surgery were compared between groups.
Results: Sufentanil consumption (µg) 6 hours after surgery was higher in the GDM group than in the NGDM group (24.0±6.6 vs 20.1±5.7, P=0.023). PCA was used more frequently 6 and 24 hours after surgery by the GDM group than by the NGDM group (1[0-2] vs 0[0-1], P=0.001; 6[4-8] vs 3[1-5], P=0.001, respectively). The VAS score during activity 24 hours after surgery was higher in the GDM group than in the NGDM group (5[5-6] vs 5[4-5], respectively, P=0.03).
Conclusion: Pregnant women with GDM require more opioids during the immediate postoperative period after cesarean section than those without GDM.
Keywords
Gestational diabetes mellitus; postoperative analgesia; cesarean section
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CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
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Editorial decision: Minor revision
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On 05 Dec, 2019
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Editorial decision: Major revision
On 03 Dec, 2019
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On 21 Nov, 2019
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On 20 Nov, 2019
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On 20 Nov, 2019
Version 2
Posted 19 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 20 Nov, 2019
Editor assigned
On 11 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Reviewer #1 agreed
On 11 Nov, 2019
Review #1 received
Received 11 Nov, 2019
Submission checks complete
On 10 Nov, 2019
Editor invited
On 10 Nov, 2019
No comments provided
Editorial decision: Major revision
On 10 Oct, 2019
Review #2 received
Received 18 Sep, 2019
Reviewer #2 agreed
On 11 Sep, 2019
Review #1 received
Received 11 May, 2019
Reviewer #1 agreed
On 08 May, 2019
Reviewers invited
Invitations sent on 05 May, 2019
Editor assigned
On 20 Apr, 2019
Submission checks complete
On 18 Apr, 2019
Editor invited
On 18 Apr, 2019
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On 03 Apr, 2019
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A new preprint design is coming!
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See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Shaoqiang Huang
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0515-8099
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
No community comments so far
Editorial decision: Minor revision
On 18 Dec, 2019
Editor assigned
On 05 Dec, 2019
Submission checks complete
On 04 Dec, 2019
Editor invited
On 04 Dec, 2019
No comments provided
Editorial decision: Major revision
On 03 Dec, 2019
Editor assigned
On 21 Nov, 2019
Submission checks complete
On 20 Nov, 2019
Editor invited
On 20 Nov, 2019
Version 2
Posted 19 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 20 Nov, 2019
Editor assigned
On 11 Nov, 2019
Reviewers invited
Invitations sent on 11 Nov, 2019
Reviewer #1 agreed
On 11 Nov, 2019
Review #1 received
Received 11 Nov, 2019
Submission checks complete
On 10 Nov, 2019
Editor invited
On 10 Nov, 2019
No comments provided
Editorial decision: Major revision
On 10 Oct, 2019
Review #2 received
Received 18 Sep, 2019
Reviewer #2 agreed
On 11 Sep, 2019
Review #1 received
Received 11 May, 2019
Reviewer #1 agreed
On 08 May, 2019
Reviewers invited
Invitations sent on 05 May, 2019
Editor assigned
On 20 Apr, 2019
Submission checks complete
On 18 Apr, 2019
Editor invited
On 18 Apr, 2019
First submitted
On 03 Apr, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Anesthesiology.
Background: Previous studies have shown that patients with long-term diabetes require more opioids after surgery than patients without diabetes. Gestational diabetes mellitus (GDM) normally only lasts for a brief period; nevertheless, its effect on sufentanil consumption after cesarean section is unknown.
Methods: This prospective cohort study included two groups: a GDM group (n=32) and a matched non-GDM (NGDM) group (n=32). All patients underwent routine combined spinal-epidural anesthesia for cesarean delivery. Sufentanil consumption through an intravenous patient-controlled analgesia (PCA) pump, the frequency of PCA requests, and visual analog scale (VAS) scores 6 and 24 hours after surgery were compared between groups.
Results: Sufentanil consumption (µg) 6 hours after surgery was higher in the GDM group than in the NGDM group (24.0±6.6 vs 20.1±5.7, P=0.023). PCA was used more frequently 6 and 24 hours after surgery by the GDM group than by the NGDM group (1[0-2] vs 0[0-1], P=0.001; 6[4-8] vs 3[1-5], P=0.001, respectively). The VAS score during activity 24 hours after surgery was higher in the GDM group than in the NGDM group (5[5-6] vs 5[4-5], respectively, P=0.03).
Conclusion: Pregnant women with GDM require more opioids during the immediate postoperative period after cesarean section than those without GDM.
Figure 1
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