See the published version of this preprint at Arthritis Research & Therapy.
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Research article
Richard Day
St Vincent’s Hospital, Darlinghurst
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6045-6937
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over one-to-two years in people with painful medial knee osteoarthritis.
Methods:
A longitudinal study was conducted within a randomised controlled trial, the “Long-term Evaluation of Glucosamine Sulfate” (LEGS study). Recruitment occurred 2007-2009, with one and two-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean[sd] age: 60[8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden’s nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over one-to-two years (latest follow-up used where available).
Results:
Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were: use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95%CI:1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95%CI:0.9 to 4.7).
Conclusions:
Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have greater risk of radiographic osteoarthritis progression.
Trial Registration:
This original study trial was registered apriori. ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov. Current study hypothesis arose before inspection of the data.
Keywords
Knee osteoarthritis, disease progression, risk factors, epidemiology, non-steroidal anti-inflammatory drugs
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CURRENT STATUS: Published
View the published article at Arthritis Research & Therapy.
Version 1
Posted 02 Sep, 2020
No community comments so far
Editorial decision: Minor revision
On 17 Apr, 2021
Review #1 received
Received 11 Mar, 2021
Reviewer #1 agreed
On 19 Feb, 2021
Reviewers invited
Invitations sent on 07 Nov, 2020
Editor assigned
On 30 Aug, 2020
Submission checks complete
On 29 Aug, 2020
Editor invited
On 29 Aug, 2020
First submitted
On 28 Aug, 2020
Metrics
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PDF Downloads: ...
HTML Views: ...
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See the published version of this preprint at Arthritis Research & Therapy.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Richard Day
St Vincent’s Hospital, Darlinghurst
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6045-6937
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Arthritis Research & Therapy.
Version 1
Posted 02 Sep, 2020
No community comments so far
Editorial decision: Minor revision
On 17 Apr, 2021
Review #1 received
Received 11 Mar, 2021
Reviewer #1 agreed
On 19 Feb, 2021
Reviewers invited
Invitations sent on 07 Nov, 2020
Editor assigned
On 30 Aug, 2020
Submission checks complete
On 29 Aug, 2020
Editor invited
On 29 Aug, 2020
First submitted
On 28 Aug, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Arthritis Research & Therapy.
Background:
The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over one-to-two years in people with painful medial knee osteoarthritis.
Methods:
A longitudinal study was conducted within a randomised controlled trial, the “Long-term Evaluation of Glucosamine Sulfate” (LEGS study). Recruitment occurred 2007-2009, with one and two-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean[sd] age: 60[8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden’s nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over one-to-two years (latest follow-up used where available).
Results:
Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were: use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95%CI:1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95%CI:0.9 to 4.7).
Conclusions:
Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have greater risk of radiographic osteoarthritis progression.
Trial Registration:
This original study trial was registered apriori. ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov. Current study hypothesis arose before inspection of the data.
Figure 1
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