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Research article
Gelin Xu
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Patients with vertebrobasilar dolichoectasia usually have persistent hemodynamic abnormalities, and therefore, may bear an increased risk of stroke. This study aimed to identify risk factors for stroke recurrence in patients with vertebrobasilar dolichoectasia.
Methods: Patients with acute ischemic stroke were screened and evaluated for eligibility. Enrolled patients were followed via scheduled clinical visits or telephone interviews. Ischemic stroke recurrence was proposed with clinical symptoms and confirmed with cranial Magnetic Resonance Imaging or Computerized Tomography scans. Baseline characteristics and vascular geometry were compared between patients with and without stroke recurrence. Significant parameters were introduced into COX proportional hazard model to detect possible predictors of stroke recurrence.
Results: A total of 115 stroke patients with vertebrobasilar dolichoectasia were enrolled, of which 22 (19.1%) had recurrence during 22 ± 6 months follow-up. Basilar artery diameter ≥ 5.3mm (HR = 4.744; 95% CI, 1.718-13.097; P = 0.003), diffuse intracranial dolichoectasia (HR = 3.603; 95% CI, 1.367-9.496; P = 0.010) and ischemic heart disease history (HR = 4.095; 95% CI, 1.221-13.740; P = 0.022) had increased risk of recurrence.
Conclusions: Stroke patients with vertebrobasilar dolichoectasia may have a high risk of recurrence. Larger basilar artery diameter or diffuse intracranial dolichoectasia may increase the risk of recurrence.
Keywords
Vertebrobasilar Dolichoectasia, Stroke Recurrence, Intracranial Atherosclerosis, Ischemic Heart Disease
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CURRENT STATUS: Published
View the published article at BMC Neurology.
Version 2
Posted 05 Jun, 2019
No community comments so far
Editorial decision: Accept
On 09 Jul, 2019
Review #1 received
Received 27 Jun, 2019
Review #2 received
Received 27 Jun, 2019
Reviewer #2 agreed
On 25 Jun, 2019
Reviewers invited
Invitations sent on 06 Jun, 2019
Reviewer #1 agreed
On 06 Jun, 2019
Submission checks complete
On 04 Jun, 2019
Editor invited
On 04 Jun, 2019
Editor assigned
On 04 Jun, 2019
No comments provided
Editorial decision: Minor revision
On 28 May, 2019
Review #2 received
Received 27 May, 2019
Review #1 received
Received 23 May, 2019
Reviewer #2 agreed
On 09 May, 2019
Reviewer #1 agreed
On 06 May, 2019
Reviewers invited
Invitations sent on 24 Apr, 2019
Submission checks complete
On 21 Apr, 2019
Editor invited
On 03 Apr, 2019
Editor assigned
On 03 Apr, 2019
First submitted
On 30 Mar, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Neurology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Gelin Xu
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
Version 2
Posted 05 Jun, 2019
No community comments so far
Editorial decision: Accept
On 09 Jul, 2019
Review #1 received
Received 27 Jun, 2019
Review #2 received
Received 27 Jun, 2019
Reviewer #2 agreed
On 25 Jun, 2019
Reviewers invited
Invitations sent on 06 Jun, 2019
Reviewer #1 agreed
On 06 Jun, 2019
Submission checks complete
On 04 Jun, 2019
Editor invited
On 04 Jun, 2019
Editor assigned
On 04 Jun, 2019
No comments provided
Editorial decision: Minor revision
On 28 May, 2019
Review #2 received
Received 27 May, 2019
Review #1 received
Received 23 May, 2019
Reviewer #2 agreed
On 09 May, 2019
Reviewer #1 agreed
On 06 May, 2019
Reviewers invited
Invitations sent on 24 Apr, 2019
Submission checks complete
On 21 Apr, 2019
Editor invited
On 03 Apr, 2019
Editor assigned
On 03 Apr, 2019
First submitted
On 30 Mar, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Neurology.
Background: Patients with vertebrobasilar dolichoectasia usually have persistent hemodynamic abnormalities, and therefore, may bear an increased risk of stroke. This study aimed to identify risk factors for stroke recurrence in patients with vertebrobasilar dolichoectasia.
Methods: Patients with acute ischemic stroke were screened and evaluated for eligibility. Enrolled patients were followed via scheduled clinical visits or telephone interviews. Ischemic stroke recurrence was proposed with clinical symptoms and confirmed with cranial Magnetic Resonance Imaging or Computerized Tomography scans. Baseline characteristics and vascular geometry were compared between patients with and without stroke recurrence. Significant parameters were introduced into COX proportional hazard model to detect possible predictors of stroke recurrence.
Results: A total of 115 stroke patients with vertebrobasilar dolichoectasia were enrolled, of which 22 (19.1%) had recurrence during 22 ± 6 months follow-up. Basilar artery diameter ≥ 5.3mm (HR = 4.744; 95% CI, 1.718-13.097; P = 0.003), diffuse intracranial dolichoectasia (HR = 3.603; 95% CI, 1.367-9.496; P = 0.010) and ischemic heart disease history (HR = 4.095; 95% CI, 1.221-13.740; P = 0.022) had increased risk of recurrence.
Conclusions: Stroke patients with vertebrobasilar dolichoectasia may have a high risk of recurrence. Larger basilar artery diameter or diffuse intracranial dolichoectasia may increase the risk of recurrence.
Figure 1
Figure 2
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