See the published version of this article at Trials.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Study protocol
Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies
Alireza Sedaghat
Mashhad University of Medical Sciences
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Trials.
Background: Among critically ill patients, regardless of the heterogeneity of disease state, an extreme and persistent dysbiosis occurs. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrients homeostasis disturbances.
Methods: This is a prospective, single center, double-blind; a parallel randomized controlled trial that aimed to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critical care patients. A total of 40 hemodynamically- stable adult critically ill patients who receive enteral nutrition via nasogasteric tube (NGT) in the 24-48h after admission will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12h or a placebo capsule which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through nasogastric tube, separately from gavage, after feeding.
Discussion: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency and ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism.
Keywords
synbiotics, homeostasis, muscle wasting, critical care, gut microbiota
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 20 Jan, 2020
Published
On 24 Feb, 2020
No community comments so far
Editorial decision: Accept
On 03 Feb, 2020
Reviewers invited
Invitations sent on 20 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Reviewer #2 agreed
On 20 Jan, 2020
Review #1 received
Received 20 Jan, 2020
Review #2 received
Received 20 Jan, 2020
Editor assigned
On 16 Jan, 2020
Submission checks complete
On 15 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 05 Jan, 2020
Review #3 received
Received 24 Dec, 2019
Review #2 received
Received 23 Dec, 2019
Review #1 received
Received 23 Dec, 2019
Reviewer #3 agreed
On 17 Dec, 2019
Reviewer #1 agreed
On 16 Dec, 2019
Reviewer #2 agreed
On 16 Dec, 2019
Reviewers invited
Invitations sent on 15 Dec, 2019
Editor assigned
On 26 Nov, 2019
Submission checks complete
On 25 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 17 Nov, 2019
Editor assigned
On 24 Oct, 2019
Submission checks complete
On 17 Oct, 2019
First submitted
On 01 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Learn more about our company.
This preprint is under consideration at Trials. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Study protocol
Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies
Alireza Sedaghat
Mashhad University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 20 Jan, 2020
Published
On 24 Feb, 2020
No community comments so far
Editorial decision: Accept
On 03 Feb, 2020
Reviewers invited
Invitations sent on 20 Jan, 2020
Reviewer #1 agreed
On 20 Jan, 2020
Reviewer #2 agreed
On 20 Jan, 2020
Review #1 received
Received 20 Jan, 2020
Review #2 received
Received 20 Jan, 2020
Editor assigned
On 16 Jan, 2020
Submission checks complete
On 15 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 05 Jan, 2020
Review #3 received
Received 24 Dec, 2019
Review #2 received
Received 23 Dec, 2019
Review #1 received
Received 23 Dec, 2019
Reviewer #3 agreed
On 17 Dec, 2019
Reviewer #1 agreed
On 16 Dec, 2019
Reviewer #2 agreed
On 16 Dec, 2019
Reviewers invited
Invitations sent on 15 Dec, 2019
Editor assigned
On 26 Nov, 2019
Submission checks complete
On 25 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 17 Nov, 2019
Editor assigned
On 24 Oct, 2019
Submission checks complete
On 17 Oct, 2019
First submitted
On 01 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Trials.
Background: Among critically ill patients, regardless of the heterogeneity of disease state, an extreme and persistent dysbiosis occurs. Dysbiosis in critically ill patients may make them prone to hospital-acquired infections, sepsis, multi-organ failure (MOF), energy homeostasis disturbance, muscle wasting, and cachexia. Modulation of gut microbiota through synbiotics can be considered as a potential treatment for muscle wasting and macronutrients homeostasis disturbances.
Methods: This is a prospective, single center, double-blind; a parallel randomized controlled trial that aimed to evaluate the effects of synbiotic supplementation on energy and macronutrient homeostasis and muscle wasting in critical care patients. A total of 40 hemodynamically- stable adult critically ill patients who receive enteral nutrition via nasogasteric tube (NGT) in the 24-48h after admission will be included in this study. Eligible patients will be randomly assigned to receive Lactocare (ZistTakhmir) capsules 500 mg every 12h or a placebo capsule which contains only the sterile maize starch and is similar to synbiotic capsules for 14 days. The synbiotic and placebo capsules will be given through nasogastric tube, separately from gavage, after feeding.
Discussion: Gut microbiota modulation through synbiotics is proposed to improve clinical prognosis and reduce infectious complications, ventilator dependency and ICU stay by improving energy and macronutrient homeostasis and reducing muscle protein catabolism.
Figure 1
Figure 2
Figure 3