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Research article
Johnna M. Sizemore
Loyola University Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4951-1050
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Study Objective Quantify the change of insulin requirements in pre- vs post-menarchal adolescent females with type 1 diabetes (T1DM) by measuring the total daily dose (TDD; units/kg/day) of insulin administered before vs after menarche in order to provide anticipatory guidance of insulin requirements in adolescent females as they progress through puberty to help reduce the long-term complications of poorly controlled T1DM.
Design/Setting/Participants A retrospective chart review study was conducted which included 52 adolescent females with T1DM, after subjects who were diagnosed with T1DM after menarche, those on hormonal contraceptives, or those that had hypothyroidism, major medical comorbidities, or incomplete records were excluded. Subject demographics along with body mass index (BMI) percentile, HgbA1c (hemoglobin A1c), and TDD of insulin were collected 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche to assess differences in TDD of insulin in pre- and post-menarchal adolescent females with T1DM.
Interventions None
Main Outcome Measures TDD of insulin at 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche in adolescent females with T1DM.
Results There was a statistically significant difference of TDD of insulin in pre- vs. post-menarchal adolescent females with T1DM after controlling for HgbA1c and BMI.
Conclusions While poor glycemic control is often attributed to adolescent non-compliance of insulin administration, a physiologic process similar to polycystic ovarian syndrome may induce insulin resistance in post-pubertal adolescent females with T1DM.
Keywords
Type 1 diabetes, preburtal, postpubertal, premenarche, postmenarche, total daily dose of insulin, HgbA1c
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Johnna M. Sizemore
Loyola University Medical Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4951-1050
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Endocrinology & Metabolism
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Study Objective Quantify the change of insulin requirements in pre- vs post-menarchal adolescent females with type 1 diabetes (T1DM) by measuring the total daily dose (TDD; units/kg/day) of insulin administered before vs after menarche in order to provide anticipatory guidance of insulin requirements in adolescent females as they progress through puberty to help reduce the long-term complications of poorly controlled T1DM.
Design/Setting/Participants A retrospective chart review study was conducted which included 52 adolescent females with T1DM, after subjects who were diagnosed with T1DM after menarche, those on hormonal contraceptives, or those that had hypothyroidism, major medical comorbidities, or incomplete records were excluded. Subject demographics along with body mass index (BMI) percentile, HgbA1c (hemoglobin A1c), and TDD of insulin were collected 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche to assess differences in TDD of insulin in pre- and post-menarchal adolescent females with T1DM.
Interventions None
Main Outcome Measures TDD of insulin at 0-2 years pre-, 0-2 years post-, and 2-4 years post-menarche in adolescent females with T1DM.
Results There was a statistically significant difference of TDD of insulin in pre- vs. post-menarchal adolescent females with T1DM after controlling for HgbA1c and BMI.
Conclusions While poor glycemic control is often attributed to adolescent non-compliance of insulin administration, a physiologic process similar to polycystic ovarian syndrome may induce insulin resistance in post-pubertal adolescent females with T1DM.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
The full text of this article is available to read as a PDF.
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