hepatocellular carcinoma is a type of cancer that has a multi serious influence on people's health. Curcumin's effects on Hep3B growth were investigated in in Molecular and Biology Research Laboratory (G0021) at An-Najah National University − 2019–2020. According to the findings, curcumin inhibited replication, promoted apoptosis, and reduced necrosis in Hep3B cells.
According to current research, curcumin may have a powerful anti-cancer effect. Curcumin has also been demonstrated in previous studies to have anti-cancer properties, reducing cancer-related proliferation, migration, and angiogenesis in a range of cancer types [22 & 23], including several cancers of the breast [24], lung [25], colon [26], renal [27], ovarian carcinoma (silent killer) [28], pancreatic [29], osteosarcoma (also called osteogenic sarcoma) [30], T-cell acute lymphoblastic leukemia (T-ALL) [31], and the liver [32].
Targeting liver cancer stem cells is critical to avoid tumor recurrence since cancer cells show the capacity to self-restore, distinguish the difference, in addition start and prolong tumor growth. Curcumin was discovered in the current study to suppress Hep3B development. Curcumin has been shown to suppress glioblastoma stem cells from proliferating in the past, which is consistent with current findings [33].
Other research has found that contemporary malignant growth treatments based on reprogramming techniques can be applied even in tumor cells with a complex, unresolved genetic state. Hep3B cells were more effective in reprogramming than the other liver cancer cell lines. The properties of the reprogrammed Hep3B cells were similar to those of pluripotent stem cells [34].
In the twenty-first century, cancer will be the leading cause of death, and natural products should deliver innovative and more potent anticancer drugs [35]. Several clinically useful anti-cancer medicines have been created from natural compounds generated from plants. The number of promising novel drugs under clinical development based on selective activity against cancer-related molecular targets demonstrates that plants continue to play an important role in drug discovery [36]. Alkaloids (berberine), flavonoids (gambogic acid, silibinin, and wogonin), terpenes (artemisinin, ursolic acid, triptolide, and oridonin), quinones (emodin and shikonin), and saponins (ginsenoside Rg3) are among the natural compounds with anticancer potential [37].
Limitation
Difficulty in analyzing the results of curcumin effect on the cells due to the lack of apoptosis and necrosis tests in the laboratory environment of the university, which forced to send samples to other laboratories for analysis.
Recommendations
As curcumin helps to promote health in many aspects as well as reduces Hep3B necrosis, induces the apoptosis of Hep3B, and inhibits the proliferation of Hep3B, its uses are recommended to be as a part of our nutrient culture.