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Research note
Genotype-dependent Response to a Low-energy, Moderate Fiber Diet on Brain-Derived Neurotrophic Factor in Patients who are Obese and Overweight with Type 2 Diabetes
Fariba Koohdani
Tehran University of Medical Sciences
Corresponding Author
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Objective
Brain-Derived Neurotrophic Factor (BDNF) plays a key role in the pathway of the hypothalamus by reducing appetite, controlling body weight and maintaining energy balance. The aim of this study was to investigate the effects of a low-energy, moderate fiber diet on BDNF in obese and overweight type 2 diabetic patients with the APOA-II polymorphism.
Results
Serum BDNF levels increased significantly in the total participants following the low-energy, moderate fiber diet intervention (from 177.54 ± 141.54 pg/ml to 253.79 ± 206.34 pg/ml, p value = 0.025). However, the increase of serum BDNF levels did not signifcanty differ between gentyipc sub-types.
Keywords
APO AII, BDNF, Low-Energy Diet, Fiber, Genotype
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This is a preprint. It has not completed peer review.
Research note
Genotype-dependent Response to a Low-energy, Moderate Fiber Diet on Brain-Derived Neurotrophic Factor in Patients who are Obese and Overweight with Type 2 Diabetes
Fariba Koohdani
Tehran University of Medical Sciences
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 25 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
Brain-Derived Neurotrophic Factor (BDNF) plays a key role in the pathway of the hypothalamus by reducing appetite, controlling body weight and maintaining energy balance. The aim of this study was to investigate the effects of a low-energy, moderate fiber diet on BDNF in obese and overweight type 2 diabetic patients with the APOA-II polymorphism.
Results
Serum BDNF levels increased significantly in the total participants following the low-energy, moderate fiber diet intervention (from 177.54 ± 141.54 pg/ml to 253.79 ± 206.34 pg/ml, p value = 0.025). However, the increase of serum BDNF levels did not signifcanty differ between gentyipc sub-types.