1 Treede RD, Jensen TS, Campbell JN, Cruccu G, Serra J. Neuropathic pain: Redefinition and a grading system for clinical and research purposes. Neurology 2008;70:1630-1635.
2 Jensen TS, Baron R, Haanp?? M, Kalso E, Loeser JD, Rice ASC, Treede RD. A new definition of neuropathic pain. Pain 2011;152:2204-2205.
3 Dray A. Neuropathic pain: Emerging treatments. British journal of anaesthesia 2008;101:48-58.
4 Zhou YQ, Liu DQ, Chen SP, Sun J, Zhou XR, Luo F, Tian YK, Ye DW. Cellular and molecular mechanisms of calcium/calmodulin-dependent protein kinase ii in chronic pain. The Journal of pharmacology and experimental therapeutics 2017;363:176-183.
5 Yamashita A, Matsuoka Y, Matsuda M, Kawai K, Amaya F. Dysregulation of p53 and parkin induce mitochondrial dysfunction and leads to the diabetic neuropathic pain. Neuroscience 2019;416:9-19.
6 Annalisa C, Eleonora P, Valentina C. Mitochondrial dysfunction in chemotherapy-induced peripheral neuropathy (cipn). Toxics 2015;3:198-223.
7 Zhou YQ, Liu DQ, Chen SP, Sun J, Zhou XR, Rittner H, Mei W, Tian YK, Zhang HX, Chen F, Ye DW. Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain. Redox biology 2018;14:391-397.
8 Xu BY, Sun J, Chen SP, Wang XM, Chen N, Li DY, Chen G, Mei W, Tian YK, Zhou YQ, Ye DW. Nox2 contributes to reactive oxygen species-induced redox imbalance in cancer-induced bone pain. American journal of translational research 2021;13:1269-1279.
9 Dam AD, Mitchell AS, Quadrilatero J. Induction of mitochondrial biogenesis protects against caspase-dependent and caspase-independent apoptosis in l6 myoblasts. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2013;1833:3426-3435.
10 Funk JA, Odejinmi S, Schnellmann RG. Srt1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. Journal of Pharmacology & Experimental Therapeutics 2010;333:593-601.
11 Schnellmann F. Accelerated recovery of renal mitochondrial and tubule homeostasis with sirt1/pgc-1α activation following ischemia–reperfusion injury. Toxicology and applied pharmacology 2013
12 Whitaker RM, Wills LP, Stallons LJ, Schnellmann RG. Cgmp-selective phosphodiesterase inhibitors stimulate mitochondrial biogenesis and promote recovery from acute kidney injury. Journal of Pharmacology & Experimental Therapeutics 2013;347:626-634.
13 Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator pgc-1. Cell 1999;98:115-124.
14 Recent advances in understanding nrf2 as a druggable target: Development of pro-electrophilic and non-covalent nrf2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000research 2017;6
15 Sethi G. Antioxidant response elements: Discovery, classes, regulation and potential applications. Redox biology 2018;17:297-314.
16 Zhou YQ, Mei W, Tian XB, Tian YK, Ye DW. The therapeutic potential of nrf2 inducers in chronic pain: Evidence from preclinical studies. Pharmacology [?] Therapeutics 2021:107846.
17 Piantadosi CA, Carraway MS, Babiker A, Suliman HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circulation Research 2008;103:1232-1240.
18 Bernard K, Logsdon NJ, Miguel V, Benavides GA, Zhang J, Carter AB, Darley-Usmar VM, Thannickal VJ. Nadph oxidase 4 (nox4) suppresses mitochondrial biogenesis and bioenergetics in lung fibroblasts via a nuclear factor erythroid-derived 2-like 2 (nrf2)-dependent pathway *. Journal of Biological Chemistry 2017;292:3029.
19 Piantadosi CA, Withers CM, Bartz RR, Macgarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB. Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. Journal of Biological Chemistry 2011;286:16374-16385.
20 Piantadosi CA, Carraway MS, Babiker A, Suliman HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circ Res 2008;103:1232-1240.
21 Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB. Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. The Journal of biological chemistry 2011;286:16374-16385.
22 Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Cao F, Tian YK, Ye DW. Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain. Acta pharmacologica Sinica 2020
23 Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Li DY, Tian YK, Ye DW. Ppargamma activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of nrf2/ho-1 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020;129:110356.
24 Li Y, Feng YF, Liu XT, Li YC, Zhu HM, Sun MR, Li P, Liu B, Yang H. Songorine promotes cardiac mitochondrial biogenesis via nrf2 induction during sepsis. Redox biology 2021;38:101771.
25 Gureev AP, Shaforostova EA, Popov VN. Regulation of mitochondrial biogenesis as a way for active longevity: Interaction between the nrf2 and pgc-1alpha signaling pathways. Front Genet 2019;10:435.
26 Liu X, Ward K, Xavier C, Jann J, Clark AF, Pang IH, Wu H. The novel triterpenoid rta 408 protects human retinal pigment epithelial cells against h2o2-induced cell injury via nf-e2-related factor 2 (nrf2) activation. Redox biology 2016;8:98-109.
27 Reisman SA, Goldsberry AR, Lee CY, O'Grady ML, Proksch JW, Ward KW, Meyer CJ. Topical application of rta 408 lotion activates nrf2 in human skin and is well-tolerated by healthy human volunteers. BMC dermatology 2015;15:10.
28 Reisman SA, Lee CY, Meyer CJ, Proksch JW, Sonis ST, Ward KW. Topical application of the synthetic triterpenoid rta 408 protects mice from radiation-induced dermatitis. Radiation research 2014;181:512-520.
29 Reisman SA, Lee CY, Meyer CJ, Proksch JW, Ward KW. Topical application of the synthetic triterpenoid rta 408 activates nrf2 and induces cytoprotective genes in rat skin. Archives of dermatological research 2014;306:447-454.
30 Nakagami Y, Masuda K. A novel nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice. Journal of radiation research 2016;57:567-571.
31 Creelan BC, Gabrilovich DI, Gray JE, Williams CC, Tanvetyanon T, Haura EB, Weber JS, Gibney GT, Markowitz J, Proksch JW, Reisman SA, McKee MD, Chin MP, Meyer CJ, Antonia SJ. Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (rta 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors. OncoTargets and therapy 2017;10:4239-4250.
32 Lynch DR, Chin MP, Delatycki MB, Subramony SH, Corti M, Hoyle JC, Boesch S, Nachbauer W, Mariotti C, Mathews KD, Giunti P, Wilmot G, Zesiewicz T, Perlman S, Goldsberry A, O'Grady M, Meyer CJ. Safety and efficacy of omaveloxolone in friedreich ataxia (moxie study). Annals of neurology 2021;89:212-225.
33 Goldman DC, Alexeev V, Lash E, Guha C, Rodeck U, Fleming WH. The triterpenoid rta 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Radiation research 2015;183:338-344.
34 Madsen KL, Buch AE, Cohen BH, Falk MJ, Goldsberry A, Goldstein A, Karaa A, Koenig MK, Muraresku CC, Meyer C, O'Grady M, Scaglia F, Shieh PB, Vockley J, Zolkipli-Cunningham Z, Haller RG, Vissing J. Safety and efficacy of omaveloxolone in patients with mitochondrial myopathy: Motor trial. Neurology 2020;94:e687-e698.
35 Shekh-Ahmad T, Eckel R, Dayalan Naidu S, Higgins M, Yamamoto M, Dinkova-Kostova AT, Kovac S, Abramov AY, Walker MC. Keap1 inhibition is neuroprotective and suppresses the development of epilepsy. Brain : a journal of neurology 2018;141:1390-1403.
36 Song Z, Xiong B, Zheng H, Manyande A, Guan X, Cao F, Ren L, Zhou Y, Ye D, Tian Y. Stat1 as a downstream mediator of erk signaling contributes to bone cancer pain by regulating mhc ii expression in spinal microglia. Brain, behavior, and immunity 2017;60:161-173.
37 Chen SP, Sun J, Zhou YQ, Cao F, Braun C, Luo F, Ye DW, Tian YK. Sinomenine attenuates cancer-induced bone pain via suppressing microglial jak2/stat3 and neuronal camkii/creb cascades in rat models. Molecular pain 2018;14:1744806918793232.
38 Hargreaves K. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988;32
39 Li J, Ma J, Lacagnina MJ, Lorca S, Grace PM. Oral dimethyl fumarate reduces peripheral neuropathic pain in rodents via nfe2l2 antioxidant signaling. Anesthesiology 2019;132
40 Bennett GJ, Doyle T, Salvemini D. Mitotoxicity in distal symmetrical sensory peripheral neuropathies. Nature Reviews Neurology 2014;10:326.
41 Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, Duzer JV, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A. Hdac6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain 2017:1126.
42 Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 2013;53:401-426.
43 Hayashi G, Jasoliya M, Saccà F, Pane C, Filla A, Marsili A, Puorro G, Lanzillo R, Morra VB, Cortopassi G. Dimethyl fumarate mediates nrf2-dependent mitochondrial biogenesis in mice and humans. Human Molecular Genetics 2017
44 Macgarvey NC, Suliman HB, Bartz RR, Ping F, Withers CM, Welty-Wolf KE, Piantadosi CA. Activation of mitochondrial biogenesis by heme oxygenase-1-mediated nf-e2-related factor-2 induction rescues mice from lethal staphylococcus aureus sepsis. American Journal of Respiratory & Critical Care Medicine 2012;185:851-861.
45 Lim TK, Rone MB, Lee S, Antel JP, Zhang J. Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy. Molecular pain 2015;11:58.
46 Kashiwagi Y, Yi H, Liu S, Takahashi K, Hayashi K, Ikegami D, Zhu X, Gu J, Hao S. Mitochondrial biogenesis factor pgc-1alpha suppresses spinal morphine tolerance by reducing mitochondrial superoxide. Experimental neurology 2021;339:113622.
47 Gureev AP, Shaforostova EA, Popov VN. Regulation of mitochondrial biogenesis as a way for active longevity: Interaction between the nrf2 and pgc-1α signaling pathways. Frontiers in Genetics 2019;10:435-.