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Research article
Factors associated with preterm birth in Southern Ethiopia: Case-Control Study
Negeso Gebeyehu Gejo
Wachemo University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4039-1611
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pregnancy and Childbirth.
Background
Preterm birth is defined as one born alive before 37 weeks of pregnancy is completed. Worldwide, prematurity is the second foremost cause of death in children under the age of 5 years. Preterm birth also gives rise to short and long term complications. Therefore, the primary aim of this study was to identify the factors associated with preterm birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital, Hadiya Zone, Southern Ethiopia.
Methods
An institution-based unmatched case-control study was conducted from July 01, 2018 to June 30, 2019, among mothers who gave birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital. Simple random sampling technique was employed to approach study participants. SPSS version 20 software was used for data entry and computing statistical analysis. Both bivariable and multivariable logistic regression analyses were used to determine the association of each independent variable with the dependent variable. Odds ratio with their 95% confidence intervals was computed to identify the presence and strength of association, and statistical significance was affirmed if p < 0.05.
Result
The current study evaluated 213 medical records of mothers with index neonates (71 cases and 142 controls). Urban residency [AOR = 0.48; 95% Cl; 0.239, 0.962], ANC follow up [AOR = 0.08; 95 Cl; 0.008, 0.694], premature rupture of membranes [AOR = 3.78; 95% Cl; 1.467, 9.749], pregnancy induced hypertension [AOR = 3.77; 95% Cl; 1.408, 10.147], multiple pregnancies [AOR = 5.53; 95% Cl; 2.467, 12.412] were the factors associated with preterm birth. In the present study, more than one-third (36.6%) of preterm neonates have died.
Conclusions
The present study found that urban residency, ANC follow up, premature rupture of membranes, pregnancy induced hypertension and multiple pregnancies were factors associated with preterm birth. The mortality among preterm neonates is high. Enhancing ANC follow up and early detection and treatment of disorders among pregnant women during ANC and undertaking every effort to improve outcomes of preterm birth and reduce neonatal mortality associated with prematurity is decisive.
Keywords
Associated factors, Preterm birth, Southern Ethiopia
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CURRENT STATUS: Published
Editor assigned
On 01 Dec, 2020
Submission checks complete
On 01 Dec, 2020
Editor invited
On 01 Dec, 2020
Editorial decision: Minor revision
On 28 Nov, 2020
Review #2 received
Received 18 Nov, 2020
Reviewer #2 agreed
On 16 Nov, 2020
Reviewer #1 agreed
On 16 Nov, 2020
Review #1 received
Received 16 Nov, 2020
Reviewers invited
Invitations sent on 15 Nov, 2020
Editor assigned
On 11 Nov, 2020
Submission checks complete
On 11 Nov, 2020
Editor invited
On 11 Nov, 2020
Review #1 received
Received 08 Nov, 2020
Reviewer #2 agreed
On 04 Nov, 2020
Reviewer #1 agreed
On 04 Nov, 2020
Reviewers invited
Invitations sent on 01 Nov, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
Version 1
Posted 25 Sep, 2020
Published
On 07 Jan, 2021
Published
On 07 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 23 Oct, 2020
Review #1 received
Received 21 Oct, 2020
Reviewer #5 agreed
On 10 Oct, 2020
Review #2 received
Received 07 Oct, 2020
Review #3 received
Received 07 Oct, 2020
Reviewer #4 agreed
On 06 Oct, 2020
Reviewer #3 agreed
On 05 Oct, 2020
Reviewer #2 agreed
On 02 Oct, 2020
Reviewer #1 agreed
On 30 Sep, 2020
Editor assigned
On 27 Sep, 2020
Reviewers invited
Invitations sent on 27 Sep, 2020
Submission checks complete
On 23 Sep, 2020
Editor invited
On 22 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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This preprint is under consideration at BMC Pregnancy and Childbirth. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Factors associated with preterm birth in Southern Ethiopia: Case-Control Study
Negeso Gebeyehu Gejo
Wachemo University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4039-1611
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Editor assigned
On 01 Dec, 2020
Submission checks complete
On 01 Dec, 2020
Editor invited
On 01 Dec, 2020
Editorial decision: Minor revision
On 28 Nov, 2020
Review #2 received
Received 18 Nov, 2020
Reviewer #2 agreed
On 16 Nov, 2020
Reviewer #1 agreed
On 16 Nov, 2020
Review #1 received
Received 16 Nov, 2020
Reviewers invited
Invitations sent on 15 Nov, 2020
Editor assigned
On 11 Nov, 2020
Submission checks complete
On 11 Nov, 2020
Editor invited
On 11 Nov, 2020
Review #1 received
Received 08 Nov, 2020
Reviewer #2 agreed
On 04 Nov, 2020
Reviewer #1 agreed
On 04 Nov, 2020
Reviewers invited
Invitations sent on 01 Nov, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
Version 1
Posted 25 Sep, 2020
Published
On 07 Jan, 2021
Published
On 07 Jan, 2021
No community comments so far
Editorial decision: Major revision
On 23 Oct, 2020
Review #1 received
Received 21 Oct, 2020
Reviewer #5 agreed
On 10 Oct, 2020
Review #2 received
Received 07 Oct, 2020
Review #3 received
Received 07 Oct, 2020
Reviewer #4 agreed
On 06 Oct, 2020
Reviewer #3 agreed
On 05 Oct, 2020
Reviewer #2 agreed
On 02 Oct, 2020
Reviewer #1 agreed
On 30 Sep, 2020
Editor assigned
On 27 Sep, 2020
Reviewers invited
Invitations sent on 27 Sep, 2020
Submission checks complete
On 23 Sep, 2020
Editor invited
On 22 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pregnancy and Childbirth.
Background
Preterm birth is defined as one born alive before 37 weeks of pregnancy is completed. Worldwide, prematurity is the second foremost cause of death in children under the age of 5 years. Preterm birth also gives rise to short and long term complications. Therefore, the primary aim of this study was to identify the factors associated with preterm birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital, Hadiya Zone, Southern Ethiopia.
Methods
An institution-based unmatched case-control study was conducted from July 01, 2018 to June 30, 2019, among mothers who gave birth in Wachemo University Nigest Eleni Mohammed Memorial referral hospital. Simple random sampling technique was employed to approach study participants. SPSS version 20 software was used for data entry and computing statistical analysis. Both bivariable and multivariable logistic regression analyses were used to determine the association of each independent variable with the dependent variable. Odds ratio with their 95% confidence intervals was computed to identify the presence and strength of association, and statistical significance was affirmed if p < 0.05.
Result
The current study evaluated 213 medical records of mothers with index neonates (71 cases and 142 controls). Urban residency [AOR = 0.48; 95% Cl; 0.239, 0.962], ANC follow up [AOR = 0.08; 95 Cl; 0.008, 0.694], premature rupture of membranes [AOR = 3.78; 95% Cl; 1.467, 9.749], pregnancy induced hypertension [AOR = 3.77; 95% Cl; 1.408, 10.147], multiple pregnancies [AOR = 5.53; 95% Cl; 2.467, 12.412] were the factors associated with preterm birth. In the present study, more than one-third (36.6%) of preterm neonates have died.
Conclusions
The present study found that urban residency, ANC follow up, premature rupture of membranes, pregnancy induced hypertension and multiple pregnancies were factors associated with preterm birth. The mortality among preterm neonates is high. Enhancing ANC follow up and early detection and treatment of disorders among pregnant women during ANC and undertaking every effort to improve outcomes of preterm birth and reduce neonatal mortality associated with prematurity is decisive.
Figure 1