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Case Report
Xiaojun Xie
Zhejiang University School of Medicine First Affiliated Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2164-5150
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Background Parathyroid carcinoma (PC) is a rare thyroid tumor. PC with sarcomatoid differentiation(PCSD) is even rarer and its exact etiology remains unclear. We here report a case of PCSD, and present the clinicopathological features and pathological diagnosis and review the literature.
Case presentation A 71-year-old man presented with a mass of 4.5 cm × 3.5 cm in the right neck. The tumor was composed of nest-like transparent cells, and the septum had heterotypic rhabdoid cells with sarcomatoid differentiation. Immunophenotype was as follows: MyoD1, myogenin and desmin were positive; clear cells were positive for CGA, Syn and GATA-3; and Ki-67 proliferation index was 40%. Hematoxylin and eosin staining and immunohistochemistry were performed. The patient was diagnosed with PCSD, and died 6 months after surgery.
Conclusions PCSD is a rare type of primary parathyroid tumor with high malignancy and poor prognosis. Definitive diagnosis should be based on histopathological morphology and immunophenotype, and surgical treatment should be performed as soon as possible.
Keywords
parathyroid carcinoma, sacroma, parathyroid, case report, thyroid, sarcomatoid differentiation
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CURRENT STATUS: Published
View the published article at Diagnostic Pathology.
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Editorial decision: Accept
On 05 Dec, 2020
Reviewer #1 agreed
On 02 Dec, 2020
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On 28 Nov, 2020
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Editor invited
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On 28 Nov, 2020
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On 28 Nov, 2020
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Reviewer #1 agreed
On 25 Nov, 2020
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Editorial decision: Minor Revision
On 25 Nov, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
This version was not preprinted
No comments provided
Reviewer #2 agreed
On 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Review #1 received
Received 06 Nov, 2020
Reviewers invited
Invitations sent on 04 Nov, 2020
Reviewer #1 agreed
On 04 Nov, 2020
Editor assigned
On 03 Nov, 2020
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On 03 Nov, 2020
Editor invited
On 03 Nov, 2020
Version 2
Posted 26 Oct, 2020
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Review #1 received
Received 16 Oct, 2020
Editor assigned
On 14 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Reviewer #1 agreed
On 14 Oct, 2020
Reviewer #2 agreed
On 14 Oct, 2020
Submission checks complete
On 13 Oct, 2020
Editor invited
On 13 Oct, 2020
No comments provided
Editorial decision: Major Revision
On 04 Oct, 2020
Reviewer #3 agreed
On 02 Oct, 2020
Review #1 received
Received 01 Oct, 2020
Review #2 received
Received 01 Oct, 2020
Reviewer #2 agreed
On 15 Sep, 2020
Reviewer #1 agreed
On 11 Sep, 2020
Reviewers invited
Invitations sent on 10 Sep, 2020
Editor assigned
On 09 Sep, 2020
First submitted
On 08 Sep, 2020
Submission checks complete
On 08 Sep, 2020
Editor invited
On 08 Sep, 2020
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A new preprint design is coming!
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See the published version of this preprint at Diagnostic Pathology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case Report
Xiaojun Xie
Zhejiang University School of Medicine First Affiliated Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2164-5150
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Diagnostic Pathology.
No community comments so far
Editorial decision: Accept
On 05 Dec, 2020
Reviewer #1 agreed
On 02 Dec, 2020
Review #1 received
Received 02 Dec, 2020
Editor assigned
On 28 Nov, 2020
Reviewers invited
Invitations sent on 28 Nov, 2020
Submission checks complete
On 28 Nov, 2020
Editor invited
On 28 Nov, 2020
No comments provided
Editor assigned
On 28 Nov, 2020
Reviewers invited
Invitations sent on 28 Nov, 2020
Submission checks complete
On 28 Nov, 2020
Editor invited
On 28 Nov, 2020
Version (no preprint)
Posted 25 Nov, 2020
Reviewers invited
Invitations sent on 25 Nov, 2020
Reviewer #1 agreed
On 25 Nov, 2020
Review #1 received
Received 25 Nov, 2020
Editorial decision: Minor Revision
On 25 Nov, 2020
Editor assigned
On 14 Nov, 2020
Submission checks complete
On 14 Nov, 2020
Editor invited
On 14 Nov, 2020
This version was not preprinted
No comments provided
Reviewer #2 agreed
On 11 Nov, 2020
Review #2 received
Received 11 Nov, 2020
Review #1 received
Received 06 Nov, 2020
Reviewers invited
Invitations sent on 04 Nov, 2020
Reviewer #1 agreed
On 04 Nov, 2020
Editor assigned
On 03 Nov, 2020
Submission checks complete
On 03 Nov, 2020
Editor invited
On 03 Nov, 2020
Version 2
Posted 26 Oct, 2020
No comments provided
Review #1 received
Received 16 Oct, 2020
Editor assigned
On 14 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Reviewer #1 agreed
On 14 Oct, 2020
Reviewer #2 agreed
On 14 Oct, 2020
Submission checks complete
On 13 Oct, 2020
Editor invited
On 13 Oct, 2020
No comments provided
Editorial decision: Major Revision
On 04 Oct, 2020
Reviewer #3 agreed
On 02 Oct, 2020
Review #1 received
Received 01 Oct, 2020
Review #2 received
Received 01 Oct, 2020
Reviewer #2 agreed
On 15 Sep, 2020
Reviewer #1 agreed
On 11 Sep, 2020
Reviewers invited
Invitations sent on 10 Sep, 2020
Editor assigned
On 09 Sep, 2020
First submitted
On 08 Sep, 2020
Submission checks complete
On 08 Sep, 2020
Editor invited
On 08 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pathology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Diagnostic Pathology.
Background Parathyroid carcinoma (PC) is a rare thyroid tumor. PC with sarcomatoid differentiation(PCSD) is even rarer and its exact etiology remains unclear. We here report a case of PCSD, and present the clinicopathological features and pathological diagnosis and review the literature.
Case presentation A 71-year-old man presented with a mass of 4.5 cm × 3.5 cm in the right neck. The tumor was composed of nest-like transparent cells, and the septum had heterotypic rhabdoid cells with sarcomatoid differentiation. Immunophenotype was as follows: MyoD1, myogenin and desmin were positive; clear cells were positive for CGA, Syn and GATA-3; and Ki-67 proliferation index was 40%. Hematoxylin and eosin staining and immunohistochemistry were performed. The patient was diagnosed with PCSD, and died 6 months after surgery.
Conclusions PCSD is a rare type of primary parathyroid tumor with high malignancy and poor prognosis. Definitive diagnosis should be based on histopathological morphology and immunophenotype, and surgical treatment should be performed as soon as possible.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
This is a list of supplementary files associated with this preprint. Click to download.
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