See the published version of this preprint at Critical Care.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Johan A Malmgren
Sahlgrenska University Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7563-0849
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
ICU survivorship includes a diverse burden of disease. To understand the extent of the problems, the right issues must be identified, and the right questions need to be asked to the patients. Current follow-up instruments lack detailed questions in several areas relevant to survivors. Our aim was to identify health-related problems relevant and unique to ICU survivors, and to construct a comprehensive questionnaire able to address these issues.
Methods
Thirty-three ICU survivors were interviewed at least six months after ICU discharge. All types of everyday dysfunctions and disabilities were extracted and compiled into a questionnaire. The questionnaire was tested on ICU survivors and non-ICU treated subjects. Inclusion criteria for the ICU survivors were an ICU stay of at least 72 hours with the ICU discharge six months to three years prior to the study. The non-ICU treated subjects were obtained from the Swedish Population Register, matched for age and sex. Eligible participants received an invitation letter and were contacted by phone. If willing to participate, they were sent the questionnaire.
Results
Analysis of the interviews yielded 238 questions in 13 domains: cognition, fatigue, physical health, pain, psychological health, activities of daily life, sleep, appetite and alcohol, sexual health, sensory functions, gastrointestinal, urinary tract and work life.
In total, 395 of 518 ICU survivors and 197 of 231 non-ICU treated subjects returned a completed questionnaire, the response rate being 76.2% and 85.3% respectively. The two groups differed significantly in 16 of 25 comorbidities. ICU survivors differed in a majority of questions (p ≤ 0.05) compared to non-ICU treated subjects, distributed over all 13 domains.
Conclusions
This study describes the first step in developing a designated questionnaire for identification of health-related quality of life issues and long-term burden of disease after intensive care.
A first version of the questionnaire was answered by 395 ICU survivors. The questionnaire could identify that they experience severe difficulties in a wide range of domains compared to non-ICU treated subjects.
Trial registration
ClinicalTrials.gov Ref# NCT 02767180
Keywords
critical care, intensive care unit, critical illness, quality of life, follow-up studies, long term adverse effects, questionnaire, patient-reported outcome, survivors, survivorship
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- TableS1.docx
Additional file 1. Table S1 - List of scales and questionnaires discussed with interviewed ICU survivors.
- TableS2aDescriptivestatistics.xlsx
Additional file 2. Table S2a - Descriptive statistics and response rates for ICU survivors and non-ICU treated subjects.
- TableS2bDescriptivestatisticsICUspecific.xlsx
Additional file 3. Table S2b - Descriptive statistics and response rates for ICU-survivor specific questions.
- Table5Meanranksum.xlsx
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CURRENT STATUS: Published
View the published article at Critical Care.
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Editorial decision: Accept
On 07 Feb, 2021
Editor assigned
On 17 Jan, 2021
Submission checks complete
On 17 Jan, 2021
Editor invited
On 17 Jan, 2021
Version (no preprint)
Posted 02 Dec, 2020
Editorial decision: Minor revision
On 02 Dec, 2020
Review #2 received
Received 01 Dec, 2020
Reviewer #2 agreed
On 26 Nov, 2020
Reviewers invited
Invitations sent on 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Editor assigned
On 22 Nov, 2020
Submission checks complete
On 22 Nov, 2020
Editor invited
On 22 Nov, 2020
This version was not preprinted
Version 1
Posted 15 Sep, 2020
No comments provided
Editorial decision: Major revision
On 01 Oct, 2020
Review #1 received
Received 29 Sep, 2020
Review #3 received
Received 25 Sep, 2020
Reviewer #3 agreed
On 15 Sep, 2020
Reviewer #2 agreed
On 14 Sep, 2020
Review #2 received
Received 14 Sep, 2020
Reviewer #1 agreed
On 13 Sep, 2020
Reviewers invited
Invitations sent on 12 Sep, 2020
Editor invited
On 11 Sep, 2020
Editor assigned
On 10 Sep, 2020
Submission checks complete
On 09 Sep, 2020
First submitted
On 08 Sep, 2020
Metrics
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PDF Downloads: ...
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Subject Areas
Critical Care & Emergency Medicine
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See the published version of this preprint at Critical Care.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Johan A Malmgren
Sahlgrenska University Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7563-0849
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Critical Care.
No community comments so far
Editorial decision: Accept
On 07 Feb, 2021
Editor assigned
On 17 Jan, 2021
Submission checks complete
On 17 Jan, 2021
Editor invited
On 17 Jan, 2021
Version (no preprint)
Posted 02 Dec, 2020
Editorial decision: Minor revision
On 02 Dec, 2020
Review #2 received
Received 01 Dec, 2020
Reviewer #2 agreed
On 26 Nov, 2020
Reviewers invited
Invitations sent on 23 Nov, 2020
Reviewer #1 agreed
On 23 Nov, 2020
Review #1 received
Received 23 Nov, 2020
Editor assigned
On 22 Nov, 2020
Submission checks complete
On 22 Nov, 2020
Editor invited
On 22 Nov, 2020
This version was not preprinted
Version 1
Posted 15 Sep, 2020
No comments provided
Editorial decision: Major revision
On 01 Oct, 2020
Review #1 received
Received 29 Sep, 2020
Review #3 received
Received 25 Sep, 2020
Reviewer #3 agreed
On 15 Sep, 2020
Reviewer #2 agreed
On 14 Sep, 2020
Review #2 received
Received 14 Sep, 2020
Reviewer #1 agreed
On 13 Sep, 2020
Reviewers invited
Invitations sent on 12 Sep, 2020
Editor invited
On 11 Sep, 2020
Editor assigned
On 10 Sep, 2020
Submission checks complete
On 09 Sep, 2020
First submitted
On 08 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Critical Care & Emergency Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Critical Care.
Background
ICU survivorship includes a diverse burden of disease. To understand the extent of the problems, the right issues must be identified, and the right questions need to be asked to the patients. Current follow-up instruments lack detailed questions in several areas relevant to survivors. Our aim was to identify health-related problems relevant and unique to ICU survivors, and to construct a comprehensive questionnaire able to address these issues.
Methods
Thirty-three ICU survivors were interviewed at least six months after ICU discharge. All types of everyday dysfunctions and disabilities were extracted and compiled into a questionnaire. The questionnaire was tested on ICU survivors and non-ICU treated subjects. Inclusion criteria for the ICU survivors were an ICU stay of at least 72 hours with the ICU discharge six months to three years prior to the study. The non-ICU treated subjects were obtained from the Swedish Population Register, matched for age and sex. Eligible participants received an invitation letter and were contacted by phone. If willing to participate, they were sent the questionnaire.
Results
Analysis of the interviews yielded 238 questions in 13 domains: cognition, fatigue, physical health, pain, psychological health, activities of daily life, sleep, appetite and alcohol, sexual health, sensory functions, gastrointestinal, urinary tract and work life.
In total, 395 of 518 ICU survivors and 197 of 231 non-ICU treated subjects returned a completed questionnaire, the response rate being 76.2% and 85.3% respectively. The two groups differed significantly in 16 of 25 comorbidities. ICU survivors differed in a majority of questions (p ≤ 0.05) compared to non-ICU treated subjects, distributed over all 13 domains.
Conclusions
This study describes the first step in developing a designated questionnaire for identification of health-related quality of life issues and long-term burden of disease after intensive care.
A first version of the questionnaire was answered by 395 ICU survivors. The questionnaire could identify that they experience severe difficulties in a wide range of domains compared to non-ICU treated subjects.
Trial registration
ClinicalTrials.gov Ref# NCT 02767180
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- TableS1.docx
Additional file 1. Table S1 - List of scales and questionnaires discussed with interviewed ICU survivors.
- TableS2aDescriptivestatistics.xlsx
Additional file 2. Table S2a - Descriptive statistics and response rates for ICU survivors and non-ICU treated subjects.
- TableS2bDescriptivestatisticsICUspecific.xlsx
Additional file 3. Table S2b - Descriptive statistics and response rates for ICU-survivor specific questions.
- Table5Meanranksum.xlsx
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