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Research article
Sheng Lian Ma
Corresponding Author
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Background: Stroke-associated pneumonia (SAP) is a common complication of cerebrovascular disease. The A 2 DS 2 score has been used to predict the risk of SAP. However, hyperglycemia is not included in this scale. The purpose of the present study was to explore whether the A 2 DS 2 scoring system and hyperglycemia could predict the risk of SAP more effectively than the conventional A 2 DS 2 scale. Methods: This retrospective study enrolled 2,552 patients with acute ischemic stroke. The A 2 DS 2 scores, fasting blood glucose level and blood glucose level on admission were collected. Regression analysis was used to identify the independent risk factors of SAP. ROC curve analysis was used to evaluate the specificity and sensitivity of the combined A 2 DS 2 score and fasting hyperglycemia for predicting SAP. Results: Fasting hyperglycemia was an independent risk factor for SAP (OR=2.95; 95% confidence interval: 2.11-4.12; P< 0.001). The area under curve of the combined A 2 DS 2 score and fasting hyperglycemia was significantly higher than that of the A 2 DS 2 score alone (0.814 vs. 0.793; P =0.020). Conclusion: Fasting hyperglycemia is an independent risk factor for predicting SAP. Compared with the A2DS2 score, the modified A2DS2 score (combined A2DS2 score and fasting hyperglycemia) is more effective in predicting the risk of SAP. Keywords : Stroke-associated pneumonia; A 2 DS 2 score; Fasting hyperglycemia; Predictive value
Keywords
Stroke-associated pneumonia; A2DS2 score; Fasting hyperglycemia; Predictive value
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CURRENT STATUS: Published
View the published article at BMC Neurology.
Version 3
Posted 12 Oct, 2019
No community comments so far
Editorial decision: Accept
On 13 Oct, 2019
Reviewer #1 agreed
On 09 Sep, 2019
Review #1 received
Received 09 Sep, 2019
Reviewers invited
Invitations sent on 08 Sep, 2019
Editor assigned
On 27 Aug, 2019
Submission checks complete
On 26 Aug, 2019
Editor invited
On 26 Aug, 2019
No comments provided
Review #2 received
Received 15 Aug, 2019
Editorial decision: Minor revision
On 15 Aug, 2019
Reviewer #2 agreed
On 14 Aug, 2019
Reviewers invited
Invitations sent on 11 Aug, 2019
Reviewer #1 agreed
On 11 Aug, 2019
Review #1 received
Received 11 Aug, 2019
Editor assigned
On 08 Jul, 2019
Submission checks complete
On 07 Jul, 2019
Editor invited
On 07 Jul, 2019
No comments provided
Review #2 received
Received 25 May, 2019
Editorial decision: Major revision
On 25 May, 2019
Reviewer #2 agreed
On 12 May, 2019
Review #1 received
Received 27 Apr, 2019
Reviewer #1 agreed
On 26 Apr, 2019
Submission checks complete
On 25 Apr, 2019
Editor invited
On 25 Apr, 2019
Editor assigned
On 25 Apr, 2019
Reviewers invited
Invitations sent on 25 Apr, 2019
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Subject Areas
Internal Medicine Specialties
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A new preprint design is coming!
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See the published version of this preprint at BMC Neurology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Sheng Lian Ma
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Neurology.
Version 3
Posted 12 Oct, 2019
No community comments so far
Editorial decision: Accept
On 13 Oct, 2019
Reviewer #1 agreed
On 09 Sep, 2019
Review #1 received
Received 09 Sep, 2019
Reviewers invited
Invitations sent on 08 Sep, 2019
Editor assigned
On 27 Aug, 2019
Submission checks complete
On 26 Aug, 2019
Editor invited
On 26 Aug, 2019
No comments provided
Review #2 received
Received 15 Aug, 2019
Editorial decision: Minor revision
On 15 Aug, 2019
Reviewer #2 agreed
On 14 Aug, 2019
Reviewers invited
Invitations sent on 11 Aug, 2019
Reviewer #1 agreed
On 11 Aug, 2019
Review #1 received
Received 11 Aug, 2019
Editor assigned
On 08 Jul, 2019
Submission checks complete
On 07 Jul, 2019
Editor invited
On 07 Jul, 2019
No comments provided
Review #2 received
Received 25 May, 2019
Editorial decision: Major revision
On 25 May, 2019
Reviewer #2 agreed
On 12 May, 2019
Review #1 received
Received 27 Apr, 2019
Reviewer #1 agreed
On 26 Apr, 2019
Submission checks complete
On 25 Apr, 2019
Editor invited
On 25 Apr, 2019
Editor assigned
On 25 Apr, 2019
Reviewers invited
Invitations sent on 25 Apr, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Neurology.
Background: Stroke-associated pneumonia (SAP) is a common complication of cerebrovascular disease. The A 2 DS 2 score has been used to predict the risk of SAP. However, hyperglycemia is not included in this scale. The purpose of the present study was to explore whether the A 2 DS 2 scoring system and hyperglycemia could predict the risk of SAP more effectively than the conventional A 2 DS 2 scale. Methods: This retrospective study enrolled 2,552 patients with acute ischemic stroke. The A 2 DS 2 scores, fasting blood glucose level and blood glucose level on admission were collected. Regression analysis was used to identify the independent risk factors of SAP. ROC curve analysis was used to evaluate the specificity and sensitivity of the combined A 2 DS 2 score and fasting hyperglycemia for predicting SAP. Results: Fasting hyperglycemia was an independent risk factor for SAP (OR=2.95; 95% confidence interval: 2.11-4.12; P< 0.001). The area under curve of the combined A 2 DS 2 score and fasting hyperglycemia was significantly higher than that of the A 2 DS 2 score alone (0.814 vs. 0.793; P =0.020). Conclusion: Fasting hyperglycemia is an independent risk factor for predicting SAP. Compared with the A2DS2 score, the modified A2DS2 score (combined A2DS2 score and fasting hyperglycemia) is more effective in predicting the risk of SAP. Keywords : Stroke-associated pneumonia; A 2 DS 2 score; Fasting hyperglycemia; Predictive value
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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