This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research Article
Pradeep Kumar Das Mohapatra
Raiganj University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
The current nightmare for the whole world is COVID-19. The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province of China was first reported on December 30, 2019. SARS-CoV first discloses in 2002, but not outspread worldwide. After 18 years, in 2020, it reemerges and outspread worldwide as SARS-CoV-2 (COVID 19), as the most treacherous virus creating disease in the world. Is it possible to create a favorable evolution within this (18 years) short time? If possible, then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated? What are the fundamental differences between SARS-CoV-2 and SARS? This study will find all those queries. Here, we took 4 types of protein sequences from SARS-CoV-2 and SARS are retrieved from the database to check their physicochemical and structural properties. Results showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution. Those charged residues also contribute to helix stabilization of SARS-CoV-2. Formation of cyclic salt bridge and other intra-protein interactions also play crucial role in SAS-CoV-2. This comparative study will help to understand the evolution from SARS to SARS-CoV-2 and also helps in protein engineering.
Keywords
COVID-19, evolution, cyclic salt bridge, intra-protein interactions, protein engineering
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 02 Dec, 2020
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Evolutionary Biology
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Pradeep Kumar Das Mohapatra
Raiganj University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 02 Dec, 2020
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Evolutionary Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Declarations:
Declarations
- The author has confirmed that a statement listing potential conflicts of interest or lack thereof is included in the text.
The current nightmare for the whole world is COVID-19. The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province of China was first reported on December 30, 2019. SARS-CoV first discloses in 2002, but not outspread worldwide. After 18 years, in 2020, it reemerges and outspread worldwide as SARS-CoV-2 (COVID 19), as the most treacherous virus creating disease in the world. Is it possible to create a favorable evolution within this (18 years) short time? If possible, then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated? What are the fundamental differences between SARS-CoV-2 and SARS? This study will find all those queries. Here, we took 4 types of protein sequences from SARS-CoV-2 and SARS are retrieved from the database to check their physicochemical and structural properties. Results showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution. Those charged residues also contribute to helix stabilization of SARS-CoV-2. Formation of cyclic salt bridge and other intra-protein interactions also play crucial role in SAS-CoV-2. This comparative study will help to understand the evolution from SARS to SARS-CoV-2 and also helps in protein engineering.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Loading...