See the published version of this preprint at BMC Pulmonary Medicine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Ali Albarrati
King Saud University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background : Factors associated with reduced daily physical activity (DPA) in patients with COPD are still controversial. Physical inactivity in COPD increases risk of cardiovascular disease, frequent exacerbations, reduced health status, and increased symptoms. We hypothesised that reduced DPA in patients with COPD is independent of traditional risk factors including age and spirometry.
Methods : In this cross-sectional study, DPA (over 7 days) was assessed on 88 community stable patients with COPD and 40 controls free from cardiorespiratory disease. Spirometry, body composition, number of exacerbations, handgrip strength (HGS), modified Medical Research Council (mMRC), arterial stiffness, 6-minute walking distance (6MWD) and BODE index were also determined. Frequent exacerbation was defined as ≥2 and non-frequent exacerbation <2.
Results : Patients with COPD had reduced DPA and exercise capacity compared with controls similar in age, BMI and gender, p<0.001. Frequent exacerbators had less DPA than infrequent exacerbators and both less than controls, p<0.001. Patients with higher BODE index were less active than those with lower index. Time spent on moderate activity was related to cardiovascular risk factors including arterial stiffness. The DPA in patients was independent of age, gender, spirometry, body composition and HGS, p>0.05. The level of breathlessness was superior to lung function in predicting the level of DPA.
Conclusion : The level of DPA in COPD was independent of traditional risk factors. Breathlessness score is a better predictor of the DPA than lung function and handgrip strength.
Keywords
BODE index, Breathlessness, Daily activity, Exacerbation, Handgrip strength
Figure 1
Figure 2
Figure 3
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
Version 2
Posted 27 Jan, 2020
No community comments so far
Review #1 received
Received 29 Jan, 2020
Reviewers invited
Invitations sent on 25 Jan, 2020
Reviewer #1 agreed
On 25 Jan, 2020
Editor assigned
On 24 Jan, 2020
Submission checks complete
On 23 Jan, 2020
Editor invited
On 23 Jan, 2020
No comments provided
Editorial decision: Major revision
On 22 Dec, 2019
Review #2 received
Received 21 Dec, 2019
Review #1 received
Received 17 Dec, 2019
Reviewer #2 agreed
On 03 Dec, 2019
Reviewer #1 agreed
On 02 Dec, 2019
Reviewers invited
Invitations sent on 23 Nov, 2019
Submission checks complete
On 01 Nov, 2019
Editor assigned
On 29 Oct, 2019
Editor invited
On 28 Oct, 2019
First submitted
On 25 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Pulmonary Medicine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Ali Albarrati
King Saud University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
Version 2
Posted 27 Jan, 2020
No community comments so far
Review #1 received
Received 29 Jan, 2020
Reviewers invited
Invitations sent on 25 Jan, 2020
Reviewer #1 agreed
On 25 Jan, 2020
Editor assigned
On 24 Jan, 2020
Submission checks complete
On 23 Jan, 2020
Editor invited
On 23 Jan, 2020
No comments provided
Editorial decision: Major revision
On 22 Dec, 2019
Review #2 received
Received 21 Dec, 2019
Review #1 received
Received 17 Dec, 2019
Reviewer #2 agreed
On 03 Dec, 2019
Reviewer #1 agreed
On 02 Dec, 2019
Reviewers invited
Invitations sent on 23 Nov, 2019
Submission checks complete
On 01 Nov, 2019
Editor assigned
On 29 Oct, 2019
Editor invited
On 28 Oct, 2019
First submitted
On 25 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pulmonary Medicine.
Background : Factors associated with reduced daily physical activity (DPA) in patients with COPD are still controversial. Physical inactivity in COPD increases risk of cardiovascular disease, frequent exacerbations, reduced health status, and increased symptoms. We hypothesised that reduced DPA in patients with COPD is independent of traditional risk factors including age and spirometry.
Methods : In this cross-sectional study, DPA (over 7 days) was assessed on 88 community stable patients with COPD and 40 controls free from cardiorespiratory disease. Spirometry, body composition, number of exacerbations, handgrip strength (HGS), modified Medical Research Council (mMRC), arterial stiffness, 6-minute walking distance (6MWD) and BODE index were also determined. Frequent exacerbation was defined as ≥2 and non-frequent exacerbation <2.
Results : Patients with COPD had reduced DPA and exercise capacity compared with controls similar in age, BMI and gender, p<0.001. Frequent exacerbators had less DPA than infrequent exacerbators and both less than controls, p<0.001. Patients with higher BODE index were less active than those with lower index. Time spent on moderate activity was related to cardiovascular risk factors including arterial stiffness. The DPA in patients was independent of age, gender, spirometry, body composition and HGS, p>0.05. The level of breathlessness was superior to lung function in predicting the level of DPA.
Conclusion : The level of DPA in COPD was independent of traditional risk factors. Breathlessness score is a better predictor of the DPA than lung function and handgrip strength.
Figure 1
Figure 2
Figure 3
Loading...