Ethics approval and consent to participate
Not applicable
Consent for publication
Not applicable
Availability of data and materials
Data are available from the corresponding authors on reasonable request.
Competing interests
AG reports having received honoraria (Clovis, MSD, AstraZeneca, GSK, PharmaMar and Roche) and travel/accommodation/expenses (Merck Sharp & Dohme, PharmaMar, Roche, Eisai, Pfizer, Pierre-Fabre and Tesaro-A GSK Company) outside the submitted work.
VM reports having received honoraria as speaker from Roche, Pfizer, Novartis, Lilly, Rovi and Bayer.
JF has received consulting and advisory honoraria from Amgen, Ipsen, Eisai, Sirtex, Merck, Roche and Novartis; research funding from Merck; and travel and accommodation expenses from Amgen and Servier.
AR reports having received honoraria and providing advisory/consultancy services (MSD, AstraZeneca, Roche, GSK, Clovis, PharmaMar, Lilly, Amgen), as well as having received research grant/funding to his institution (Eisai, PharmaMar, Roche), travel/accommodation/expenses (AstraZeneca, Tesaro: A GSK Company, PharmaMar, Roche), and participating in a speakers bureau (MSD, AstraZeneca, Roche, GSK, Clovis, PharmaMar) outside the submitted work.
MM reports having received honoraria (MSD, AstraZeneca and GSK), research grant/funding to her institution (Eisai and PharmaMar), and travel/accommodation/expenses (AstraZeneca, GSK, PharmaMar, Roche and Pfizer) outside the submitted work.
The remaining authors declare no conflicts of interest.
Funding
This project was funded by Eisai Farmaceutica SA (Spain) with no intervention in its concept, design, or results interpretation.
Author´s contributions
These are the main contributions by authors:
-Conceptualisation and resources (JT, AR, MM)
-Data curation (JE, VHS, YW, AG, JPK, AB, VMM, DB)
-Software and visualisation (YW, JT)
-Methodology and Formal analysis (JE, VHS, PR, AR, MM)
-Supervision and funding acquisition (DH, JF, EOC, AR, MM)
-Writing and editing original draft (JE, VHS, JT, AR, MM)
All authors have read, reviewed and approved the final manuscript.
Acknowledgements
We thank MDAnderson Cytogenetics and Cell Authentication core facility (USA) and Dr. Carnero from the Biomedicine Institute (Spain) for the cell lines.