Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy
Background: To investigate preoperative clinical factors and visual outcomes of Japanese patients with dysthyroid optic neuropathy (DON) after urgent orbital decompression.Methods: This retrospective, observational case series study investigated 44 patients who exhibited several preoperative clinical factors that might be associated with the need for urgent orbital decompression due to DON. Additionally, the visual acuity of DON patients was compared between the patients preoperatively and at 1 and 6 months postoperatively.Results: All 44 patients received steroid and with or without radiation therapy, with 27 patients able to avoid undergoing urgent surgery. However, the remaining 17 patients required urgent orbital decompression following a lack of response to the therapy. None of the patients who initially avoided surgery required additional surgery for DON. Factors significantly associated with the need for urgent orbital decompression surgery included: female gender, older age, long disease duration, unilateral significant DON, history of resistance to pulsed steroid therapy, unstable thyroid function, high TRAb(Thyrotrophin receptor antibody )value, poor visual acuity, presence of central diplopia, and presence of corneal problems (P<0.05 each). The results also showed that postoperative visual outcomes of surgery for DON were acceptable.Conclusion: This study revealed several preoperative clinical factors for DON that appear to be associated with the need for urgent orbital decompression surgery in Japanese patients.
Figure 1
Figure 2
Posted 13 Jan, 2020
On 17 Jan, 2020
On 10 Jan, 2020
On 10 Jan, 2020
On 08 Jan, 2020
On 30 Dec, 2019
On 29 Dec, 2019
On 29 Dec, 2019
Received 26 Dec, 2019
On 26 Dec, 2019
Received 08 Dec, 2019
On 02 Dec, 2019
On 24 Nov, 2019
Invitations sent on 20 Nov, 2019
On 31 Oct, 2019
On 30 Oct, 2019
On 30 Oct, 2019
Preoperative clinical factors and visual outcomes following orbital decompression with dysthyroid optic neuropathy
Posted 13 Jan, 2020
On 17 Jan, 2020
On 10 Jan, 2020
On 10 Jan, 2020
On 08 Jan, 2020
On 30 Dec, 2019
On 29 Dec, 2019
On 29 Dec, 2019
Received 26 Dec, 2019
On 26 Dec, 2019
Received 08 Dec, 2019
On 02 Dec, 2019
On 24 Nov, 2019
Invitations sent on 20 Nov, 2019
On 31 Oct, 2019
On 30 Oct, 2019
On 30 Oct, 2019
Background: To investigate preoperative clinical factors and visual outcomes of Japanese patients with dysthyroid optic neuropathy (DON) after urgent orbital decompression.Methods: This retrospective, observational case series study investigated 44 patients who exhibited several preoperative clinical factors that might be associated with the need for urgent orbital decompression due to DON. Additionally, the visual acuity of DON patients was compared between the patients preoperatively and at 1 and 6 months postoperatively.Results: All 44 patients received steroid and with or without radiation therapy, with 27 patients able to avoid undergoing urgent surgery. However, the remaining 17 patients required urgent orbital decompression following a lack of response to the therapy. None of the patients who initially avoided surgery required additional surgery for DON. Factors significantly associated with the need for urgent orbital decompression surgery included: female gender, older age, long disease duration, unilateral significant DON, history of resistance to pulsed steroid therapy, unstable thyroid function, high TRAb(Thyrotrophin receptor antibody )value, poor visual acuity, presence of central diplopia, and presence of corneal problems (P<0.05 each). The results also showed that postoperative visual outcomes of surgery for DON were acceptable.Conclusion: This study revealed several preoperative clinical factors for DON that appear to be associated with the need for urgent orbital decompression surgery in Japanese patients.
Figure 1
Figure 2