Tumor Characteristics and Treatment Outcomes of Older Patients with Breast Cancer in Jordan
Background: Less than 10% of newly diagnosed breast cancer cases in Jordan are diagnosed in women 70 years or older. Treatment plans of such patients is less clear and could result in poor outcomes. In this paper, we describe clinical presentation, tumor characteristics and treatment outcomes in this population of breast cancer patients.
Methods: Consecutive patients aged 65 years or older with pathologically-confirmed diagnosis of breast cancer were included. Medical records and hospital databases were searched for patients’ characteristics and treatment outcomes.
Results: A total of 553 patients, mean age ± SD (71± 5.1) years, were included. On presentation, 114 (20.6%) patients had metastatic disease and was mostly visceral (81; 71.1%). Patients with non-metastatic disease had poor pathological features including node-positive in 244 (55.6%), high grade (grade III) in 170 (38.7%) and lymphovascular invasion in 173 (39.4%). Patients were treated less aggressively; 144 (32.8%) patients with early-stage disease and 98 (86.0%) with metastatic disease never had chemotherapy.
After a median follow up of 45 months, 5-year overall survival for the whole group was 67.6%. Survival was better for patients with non-metastatic disease (78.8% vs. 25.4%, P<0.001) and for those with node-negative compared to node-positive disease (85.4% vs. 74.1%, P=0.002). On Cox regression, only positive lymph nodes were associated with poor outcome in patients with non-metastatic disease (Hazard Ratio [HR], 1.75; 95% CI: 1.006-3.034, P=0.048).
Conclusions: Older Jordanian patients with breast cancer present with more aggressive features and advanced-stage disease that reflect poorly on treatment outcomes. Older patients were treated less aggressively with less than a third received any chemotherapy.
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Tumor Characteristics and Treatment Outcomes of Older Patients with Breast Cancer in Jordan
Posted 16 Apr, 2020
On 19 May, 2020
On 13 Apr, 2020
On 12 Apr, 2020
On 12 Apr, 2020
On 07 Apr, 2020
On 19 Mar, 2020
Received 19 Mar, 2020
Received 18 Mar, 2020
On 08 Mar, 2020
Invitations sent on 06 Mar, 2020
On 20 Feb, 2020
On 19 Feb, 2020
On 19 Feb, 2020
On 18 Feb, 2020
Received 09 Feb, 2020
On 26 Jan, 2020
Received 22 Jan, 2020
On 20 Jan, 2020
Invitations sent on 17 Jan, 2020
On 18 Dec, 2019
On 17 Dec, 2019
On 17 Dec, 2019
On 13 Dec, 2019
Received 10 Dec, 2019
Received 10 Dec, 2019
On 26 Nov, 2019
Received 20 Nov, 2019
On 18 Nov, 2019
On 18 Nov, 2019
Invitations sent on 15 Nov, 2019
On 09 Nov, 2019
On 04 Nov, 2019
On 03 Nov, 2019
On 28 Oct, 2019
Background: Less than 10% of newly diagnosed breast cancer cases in Jordan are diagnosed in women 70 years or older. Treatment plans of such patients is less clear and could result in poor outcomes. In this paper, we describe clinical presentation, tumor characteristics and treatment outcomes in this population of breast cancer patients.
Methods: Consecutive patients aged 65 years or older with pathologically-confirmed diagnosis of breast cancer were included. Medical records and hospital databases were searched for patients’ characteristics and treatment outcomes.
Results: A total of 553 patients, mean age ± SD (71± 5.1) years, were included. On presentation, 114 (20.6%) patients had metastatic disease and was mostly visceral (81; 71.1%). Patients with non-metastatic disease had poor pathological features including node-positive in 244 (55.6%), high grade (grade III) in 170 (38.7%) and lymphovascular invasion in 173 (39.4%). Patients were treated less aggressively; 144 (32.8%) patients with early-stage disease and 98 (86.0%) with metastatic disease never had chemotherapy.
After a median follow up of 45 months, 5-year overall survival for the whole group was 67.6%. Survival was better for patients with non-metastatic disease (78.8% vs. 25.4%, P<0.001) and for those with node-negative compared to node-positive disease (85.4% vs. 74.1%, P=0.002). On Cox regression, only positive lymph nodes were associated with poor outcome in patients with non-metastatic disease (Hazard Ratio [HR], 1.75; 95% CI: 1.006-3.034, P=0.048).
Conclusions: Older Jordanian patients with breast cancer present with more aggressive features and advanced-stage disease that reflect poorly on treatment outcomes. Older patients were treated less aggressively with less than a third received any chemotherapy.
Figure 1
Figure 2
Figure 3