Roll-Bond cladded plates are widely used in industry. Stainless steels, Ni, Cu and Ti are used as clad usually. In multi-piece head manufacturing, while these plates press to form petals, delamination occurs in some cases. In this paper, the effective parameters on delamination are investigated. Because of more widely used in respective industry, SA 516 GR 70 as base plate and SS 316L as clad are selected. First of common criteria for defining delamination, the strain energy release rate (SERR), as explanatory parameter selected and calculated using finite element technique and VCCT method. Interface is modeled as cohesive zone with tied mesh technique and by validated experimental work. The design of experiment method is response surface methodology (RSM), and effect of input parameters on output parameter, SERR, is obtained. Results indicate that head radius have greatest impact on G and then thickness of the plate, pressing force, number of pressing steps, shear strength and friction coefficient are placed in the next rows. Among these, when the radius of the head and shear strength increase, SERR decrease and the head radius impact is much greater than shear strength. Finally, in order to prevent delamination, some strategies have been proposed.