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Research article
Bruno Minotti
Kantonsspital Sankt Gallen
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4820-9968
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Urology.
Background This systematic review and meta-analysis aims to investigate the prevalence of microhematuria in patients presenting with suspected acute renal colic and/or confirmed urolithiasis at the emergency department.
Methods A comprehensive literature search was conducted to find relevant data on prevalence of microhematuria in patients with suspected acute renal colic and/or confirmed urolithiasis. Data from each study regarding study design, patient characteristics and prevalence of microhematuria were retrieved. A random effect-model was used for the pooled analyses.
Results Forty-nine articles including 15’860 patients were selected through the literature search. The pooled microhematuria prevalence was 77% (95%CI: 73-80%) and 84% (95%CI: 80-87%) for suspected acute renal colic and confirmed urolithiasis, respectively. This proportion was much higher when the dipstick was used as diagnostic test (80% and 90% for acute renal colic and urolithiasis, respectively) compared to the microscopic urinalysis (74% and 78% for acute renal colic and urolithiasis, respectively).
Conclusions This meta-analysis revealed a high prevalence of microhematuria in patients with acute renal colic (77%), including those with confirmed urolithiasis (84%). Intending this prevalence as sensitivity, we reached moderate values, which make microhematuria alone a poor diagnostic test for acute renal colic or urolithiasis. Microhematuria could possibly still important to assess the risk in patients with renal colic.
Keywords
renal colic, urolithiasis, microhematuria, stone score
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Supplemental figure 1 Overall quality assessment of the studies included in the systematic review according to QUADAS-2 tool.
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CURRENT STATUS: Published
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Posted 08 Jul, 2020
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On 08 Aug, 2020
No community comments so far
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Received 09 Jul, 2020
Editor assigned
On 07 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Reviewer #1 agreed
On 07 Jul, 2020
Submission checks complete
On 06 Jul, 2020
Editor invited
On 06 Jul, 2020
No comments provided
Editorial decision: Major revision
On 09 Jun, 2020
Review #2 received
Received 11 Feb, 2020
Reviewer #2 agreed
On 01 Feb, 2020
Review #1 received
Received 27 Nov, 2019
Reviewer #1 agreed
On 22 Nov, 2019
Reviewers invited
Invitations sent on 21 Nov, 2019
Editor assigned
On 17 Oct, 2019
First submitted
On 16 Oct, 2019
Submission checks complete
On 16 Oct, 2019
Editor invited
On 16 Oct, 2019
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Subject Areas
Urology & Nephrology
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This preprint is under consideration at BMC Urology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Bruno Minotti
Kantonsspital Sankt Gallen
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4820-9968
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 08 Jul, 2020
Published
On 08 Aug, 2020
No community comments so far
Review #1 received
Received 09 Jul, 2020
Editor assigned
On 07 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Reviewer #1 agreed
On 07 Jul, 2020
Submission checks complete
On 06 Jul, 2020
Editor invited
On 06 Jul, 2020
No comments provided
Editorial decision: Major revision
On 09 Jun, 2020
Review #2 received
Received 11 Feb, 2020
Reviewer #2 agreed
On 01 Feb, 2020
Review #1 received
Received 27 Nov, 2019
Reviewer #1 agreed
On 22 Nov, 2019
Reviewers invited
Invitations sent on 21 Nov, 2019
Editor assigned
On 17 Oct, 2019
First submitted
On 16 Oct, 2019
Submission checks complete
On 16 Oct, 2019
Editor invited
On 16 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Urology & Nephrology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Urology.
Background This systematic review and meta-analysis aims to investigate the prevalence of microhematuria in patients presenting with suspected acute renal colic and/or confirmed urolithiasis at the emergency department.
Methods A comprehensive literature search was conducted to find relevant data on prevalence of microhematuria in patients with suspected acute renal colic and/or confirmed urolithiasis. Data from each study regarding study design, patient characteristics and prevalence of microhematuria were retrieved. A random effect-model was used for the pooled analyses.
Results Forty-nine articles including 15’860 patients were selected through the literature search. The pooled microhematuria prevalence was 77% (95%CI: 73-80%) and 84% (95%CI: 80-87%) for suspected acute renal colic and confirmed urolithiasis, respectively. This proportion was much higher when the dipstick was used as diagnostic test (80% and 90% for acute renal colic and urolithiasis, respectively) compared to the microscopic urinalysis (74% and 78% for acute renal colic and urolithiasis, respectively).
Conclusions This meta-analysis revealed a high prevalence of microhematuria in patients with acute renal colic (77%), including those with confirmed urolithiasis (84%). Intending this prevalence as sensitivity, we reached moderate values, which make microhematuria alone a poor diagnostic test for acute renal colic or urolithiasis. Microhematuria could possibly still important to assess the risk in patients with renal colic.
Figure 1
Figure 2
Figure 3
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