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Research article
Run-Chang Wang
Huazhong University of Science and Technology Tongji Medical College
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6044-9203
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The association between the lymphocyte-to-monocyte ratio (LMR) and prognosis of patients with acute coronary syndrome (ACS) is not fully understood. We performed this systematic review and meta-analysis to evaluate the correlation between LMR and mortality or major adverse cardiac events (MACE) in patients with ACS.
Methods: A systematic search was performed in PubMed, MEDLINE, EMBASE, the Cochrane Library, Scopus and Web of science. The association between LMR and mortality or MACE was analyzed in patients with ACS. The search was updated to April 15, 2020.
Results: A total of 5 studies comprising 4343 patients were included in this meta-analysis. The results showed that lower LMR predicted short-term mortality/MACE (hazard ratio [HR] = 3.44, 95% confidence interval [CI]: 1.46–8.14, P < 0.05) and higher long-term mortality/MACE (HR = 1.70, 95% CI: 1.36– 2.13, P < 0.05). According to our subgroup analysis, there is still has a statistical significance for LMR to predict long-term mortality/MACE in any subgroups.
Conclusions: This study suggested that lower LMR value might be associated with higher short-term mortality/MACE and long-term mortality/MACE in ACS patients. Especially for younger ACS patients, low LMR was more closely associated with poor prognosis.
Keywords
Lymphocyte-to-monocyte ratio, Mortality, Major adverse cardiac events, Acute coronary syndrome
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View the published article at BMC Cardiovascular Disorders.
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On 26 Jun, 2020
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Editorial decision: Minor revision
On 19 Jun, 2020
Editor assigned
On 25 May, 2020
Submission checks complete
On 24 May, 2020
Editor invited
On 24 May, 2020
Version 2
Posted 12 May, 2020
No comments provided
Editorial decision: Major revision
On 13 May, 2020
Editor assigned
On 27 Apr, 2020
Submission checks complete
On 26 Apr, 2020
Editor invited
On 26 Apr, 2020
No comments provided
Editorial decision: Major revision
On 31 Mar, 2020
Review #2 received
Received 18 Feb, 2020
Reviewer #2 agreed
On 06 Feb, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 18 Dec, 2019
Reviewers invited
Invitations sent on 09 Oct, 2019
Editor assigned
On 05 Sep, 2019
Submission checks complete
On 04 Sep, 2019
Editor invited
On 04 Sep, 2019
First submitted
On 03 Sep, 2019
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Subject Areas
Cardiac & Cardiovascular Systems
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A new preprint design is coming!
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See the published version of this preprint at BMC Cardiovascular Disorders.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Run-Chang Wang
Huazhong University of Science and Technology Tongji Medical College
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6044-9203
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Cardiovascular Disorders.
No community comments so far
Submission checks complete
On 26 Jun, 2020
No comments provided
Editorial decision: Minor revision
On 19 Jun, 2020
Editor assigned
On 25 May, 2020
Submission checks complete
On 24 May, 2020
Editor invited
On 24 May, 2020
Version 2
Posted 12 May, 2020
No comments provided
Editorial decision: Major revision
On 13 May, 2020
Editor assigned
On 27 Apr, 2020
Submission checks complete
On 26 Apr, 2020
Editor invited
On 26 Apr, 2020
No comments provided
Editorial decision: Major revision
On 31 Mar, 2020
Review #2 received
Received 18 Feb, 2020
Reviewer #2 agreed
On 06 Feb, 2020
Review #1 received
Received 30 Dec, 2019
Reviewer #1 agreed
On 18 Dec, 2019
Reviewers invited
Invitations sent on 09 Oct, 2019
Editor assigned
On 05 Sep, 2019
Submission checks complete
On 04 Sep, 2019
Editor invited
On 04 Sep, 2019
First submitted
On 03 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Cardiovascular Disorders.
Background: The association between the lymphocyte-to-monocyte ratio (LMR) and prognosis of patients with acute coronary syndrome (ACS) is not fully understood. We performed this systematic review and meta-analysis to evaluate the correlation between LMR and mortality or major adverse cardiac events (MACE) in patients with ACS.
Methods: A systematic search was performed in PubMed, MEDLINE, EMBASE, the Cochrane Library, Scopus and Web of science. The association between LMR and mortality or MACE was analyzed in patients with ACS. The search was updated to April 15, 2020.
Results: A total of 5 studies comprising 4343 patients were included in this meta-analysis. The results showed that lower LMR predicted short-term mortality/MACE (hazard ratio [HR] = 3.44, 95% confidence interval [CI]: 1.46–8.14, P < 0.05) and higher long-term mortality/MACE (HR = 1.70, 95% CI: 1.36– 2.13, P < 0.05). According to our subgroup analysis, there is still has a statistical significance for LMR to predict long-term mortality/MACE in any subgroups.
Conclusions: This study suggested that lower LMR value might be associated with higher short-term mortality/MACE and long-term mortality/MACE in ACS patients. Especially for younger ACS patients, low LMR was more closely associated with poor prognosis.
Figure 1
Figure 2
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