Acknowledgments
The authors thank all patients and families for their participation in the MCC-Spain study, as well as all study centers and collaborators.
Author’ contributions
IGA, TDS and JLL designed the study. IGA, TDS, CP, GCV, BPG, PA, TFV, EA, CSC, JA, AMB, JJJM, AIB, MDCH, JPFV, AM, NA, MSS, GB, VM, MP, MK and JLL collected the data. IGA and JLL analyzed the data. IGA, TDS and JLL interpreted the data. IGA and JLL drafted the manuscript. IGA, TDS, CP, GCV, BPG, PA, TFV, EA, CSC, JA, AMB, JJJM, AIB, MDCH, JPFV, AM, NA, MSS, GB, VM, MP, MK and JLL revised the manuscript. IGA, TDS and JLL accept responsibility for the integrity of the data analysis. All authors agree to be accountable for all the aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Funding
This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds –‘a way to build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla y León (grant LE22A10-2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006-036224-HIWATE; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action BM1206 Eucolongene. None of the funders played any role in conducting research or writing the paper.
Availability of data and materials
All data generated or analysed during this study are included in this published article [and its additional files]. Permission to use the study database will be granted to researchers outside the study group after revision and approval of each request by the Steering Committee.
Ethics approval and consent to participate
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
The protocol of MCC-Spain was approved by the Ethics committees of the participating institutions. The specific study reported here was approved by the Ethical Committee of Clinical Research of Asturias, Barcelona, Cantabria, Girona, Gipuzkoa, Huelva, León, Madrid, Navarra and Valencia. At recruitment, all participants were informed about the study objectives and signed an informed consent, which also included the authorization for following-up the patient via medical records or phone calls; only participants agreeing in being followed-up were included in the inception cohorts. Confidentiality of data is secured by removing personal identifiers in the datasets. The database was registered in the Spanish Agency for Data Protection, number 2102672171.
This article does not contain any studies with animals performed by any of the authors.
Consent for publication
Not applicable
Competing interests
All authors have read and approved the content of the article. The authors declare that they have no competing interests.