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Research article
Elevated Preoperative Neutrophil-to-lymphocyte Ratio Predicts Early Adverse Outcomes in Uncomplicated Type B Aortic Dissection Undergoing TEVAR
Zaiping Jing
Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0948-908X
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Background: Thoracic aortic endovascular repair (TEVAR) of uncomplicated type B aortic dissection (uTBAD) has favorable long-term outcomes but higher early adverse events compared with the optimal medical treatment. Recently, clinical evidence concerning vascular surgery indicates that elevated preoperative systemic inflammatory response predicts adverse clinical events. The aim of our study was to evaluate the relationship between preoperative neutrophil lymphocyte ratio (NLR) and early outcomes of (uTBAD) patients undergoing (TEVAR).
Results: 216 patients diagnosed with uTBAD were included in this retrospective study between January 2015 and December 2018. The median (IQR) follow-up period was 21 (15-33) months. An early adverse event was defined as occurring within 2 years after the procedure. Median patient age was 60 (IQR, 48-68) years and 78.7% were male. Early adverse events occurred in 24 patients (11.3%). In the multivariable analysis, preoperative NLR (HR per SD, 1.10; 95% CI, 1.03-1.18; P = 0.003) was associated with 2-year adverse events.
Conclusions: NLR is an independent predictive factor of early adverse events in uTBAD patients undergoing TEVAR.
Keywords
neutrophil lymphocyte ratio, thoracic endovascular aortic repair, uncomplicated type B aortic dissection, systemic inflammatory response, inflammatory markers
Figure 1
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Peer Review Timeline
CURRENT STATUS: Under Review
Editorial decision: Minor revision
On 08 Dec, 2020
Reviewer #3 agreed
On 04 Dec, 2020
Review #3 received
Received 04 Dec, 2020
Reviewer #2 agreed
On 01 Dec, 2020
Reviewers invited
Invitations sent on 01 Dec, 2020
Reviewer #1 agreed
On 01 Dec, 2020
Review #1 received
Received 01 Dec, 2020
Review #2 received
Received 01 Dec, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
Version 1
Posted 25 Sep, 2020
No community comments so far
Review #3 received
Received 21 Oct, 2020
Editorial decision: Major revision
On 21 Oct, 2020
Review #4 received
Received 19 Oct, 2020
Reviewer #4 agreed
On 16 Oct, 2020
Reviewer #3 agreed
On 11 Oct, 2020
Review #1 received
Received 04 Oct, 2020
Review #2 received
Received 04 Oct, 2020
Reviewers invited
Invitations sent on 03 Oct, 2020
Reviewer #1 agreed
On 03 Oct, 2020
Reviewer #2 agreed
On 03 Oct, 2020
Editor assigned
On 17 Sep, 2020
Submission checks complete
On 16 Sep, 2020
Editor invited
On 16 Sep, 2020
First submitted
On 15 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
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Subject Areas
Cardiac & Cardiovascular Systems
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This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Elevated Preoperative Neutrophil-to-lymphocyte Ratio Predicts Early Adverse Outcomes in Uncomplicated Type B Aortic Dissection Undergoing TEVAR
Zaiping Jing
Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0948-908X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Editorial decision: Minor revision
On 08 Dec, 2020
Reviewer #3 agreed
On 04 Dec, 2020
Review #3 received
Received 04 Dec, 2020
Reviewer #2 agreed
On 01 Dec, 2020
Reviewers invited
Invitations sent on 01 Dec, 2020
Reviewer #1 agreed
On 01 Dec, 2020
Review #1 received
Received 01 Dec, 2020
Review #2 received
Received 01 Dec, 2020
Editor assigned
On 15 Nov, 2020
Submission checks complete
On 15 Nov, 2020
Editor invited
On 15 Nov, 2020
Version 1
Posted 25 Sep, 2020
No community comments so far
Review #3 received
Received 21 Oct, 2020
Editorial decision: Major revision
On 21 Oct, 2020
Review #4 received
Received 19 Oct, 2020
Reviewer #4 agreed
On 16 Oct, 2020
Reviewer #3 agreed
On 11 Oct, 2020
Review #1 received
Received 04 Oct, 2020
Review #2 received
Received 04 Oct, 2020
Reviewers invited
Invitations sent on 03 Oct, 2020
Reviewer #1 agreed
On 03 Oct, 2020
Reviewer #2 agreed
On 03 Oct, 2020
Editor assigned
On 17 Sep, 2020
Submission checks complete
On 16 Sep, 2020
Editor invited
On 16 Sep, 2020
First submitted
On 15 Sep, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Thoracic aortic endovascular repair (TEVAR) of uncomplicated type B aortic dissection (uTBAD) has favorable long-term outcomes but higher early adverse events compared with the optimal medical treatment. Recently, clinical evidence concerning vascular surgery indicates that elevated preoperative systemic inflammatory response predicts adverse clinical events. The aim of our study was to evaluate the relationship between preoperative neutrophil lymphocyte ratio (NLR) and early outcomes of (uTBAD) patients undergoing (TEVAR).
Results: 216 patients diagnosed with uTBAD were included in this retrospective study between January 2015 and December 2018. The median (IQR) follow-up period was 21 (15-33) months. An early adverse event was defined as occurring within 2 years after the procedure. Median patient age was 60 (IQR, 48-68) years and 78.7% were male. Early adverse events occurred in 24 patients (11.3%). In the multivariable analysis, preoperative NLR (HR per SD, 1.10; 95% CI, 1.03-1.18; P = 0.003) was associated with 2-year adverse events.
Conclusions: NLR is an independent predictive factor of early adverse events in uTBAD patients undergoing TEVAR.
Figure 1