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Research article
High detection rate of osteoporosis with screening of a general hospitalized population: a 6-year study in 6406 patients in a University Hospital setting.
Olivier Malaise
Centre hospitalier universitaire de Liege
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2799-2949
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Musculoskeletal Disorders.
Background: Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated the use of baseline in-hospital DEXA screening to identify osteoporosis in ambulatory care and hospitalized patients; we also assessed specific risk factors for osteoporosis among these populations.
Methods: We included a baseline initial DEXA from 6406 consecutive patients at our tertiary referral University Hospital.
Results: Osteoporosis was diagnosed in 22.3% of the study population. In univariate analysis, osteoporosis risk factors were age, fracture history and low BMI (for all 3 sites), but also corticotherapy (lumbar spine and femoral neck) and male (lumbar spine). In multivariate analysis, age, fracture history, low BMI, and male increased osteoporosis risk. In-hospital screening yielded a higher percentage of osteoporosis positive scans than ambulatory care screening (31.8% vs 18.5%, p<0.001).In-hospital screening targeted an older and more predominantly male population with a higher fracture history. Z-scores revealed that this difference was not only due to an older age of the population and mainly concerned cortical bone.
Conclusions: In-hospital osteoporosis screening revealed more osteoporosis than screening in ambulatory practiceand could be an additional tool to improve the identification and management of osteoporosis. In addition to typical risk factors, we identified male as an osteoporosis risk factor in our cohort.
Keywords
Osteoporosis, Dual Energy X-ray Absorptiometry, hospitalization, male
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CURRENT STATUS: Published
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Posted 15 Jan, 2020
Published
On 10 Feb, 2020
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Review #2 received
Received 17 Jan, 2020
Reviewer #2 agreed
On 13 Jan, 2020
Reviewers invited
Invitations sent on 11 Jan, 2020
Reviewer #1 agreed
On 11 Jan, 2020
Review #1 received
Received 11 Jan, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 15 Dec, 2019
Review #1 received
Received 09 Dec, 2019
Review #2 received
Received 06 Dec, 2019
Review #3 received
Received 06 Dec, 2019
Reviewer #2 agreed
On 27 Nov, 2019
Reviewer #3 agreed
On 27 Nov, 2019
Reviewer #1 agreed
On 26 Nov, 2019
Editor assigned
On 14 Nov, 2019
Reviewers invited
Invitations sent on 14 Nov, 2019
Submission checks complete
On 12 Nov, 2019
Editor invited
On 11 Nov, 2019
First submitted
On 28 Oct, 2019
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Subject Areas
Orthopedics
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This preprint is under consideration at BMC Musculoskeletal Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
High detection rate of osteoporosis with screening of a general hospitalized population: a 6-year study in 6406 patients in a University Hospital setting.
Olivier Malaise
Centre hospitalier universitaire de Liege
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2799-2949
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 15 Jan, 2020
Published
On 10 Feb, 2020
No community comments so far
Review #2 received
Received 17 Jan, 2020
Reviewer #2 agreed
On 13 Jan, 2020
Reviewers invited
Invitations sent on 11 Jan, 2020
Reviewer #1 agreed
On 11 Jan, 2020
Review #1 received
Received 11 Jan, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 15 Dec, 2019
Review #1 received
Received 09 Dec, 2019
Review #2 received
Received 06 Dec, 2019
Review #3 received
Received 06 Dec, 2019
Reviewer #2 agreed
On 27 Nov, 2019
Reviewer #3 agreed
On 27 Nov, 2019
Reviewer #1 agreed
On 26 Nov, 2019
Editor assigned
On 14 Nov, 2019
Reviewers invited
Invitations sent on 14 Nov, 2019
Submission checks complete
On 12 Nov, 2019
Editor invited
On 11 Nov, 2019
First submitted
On 28 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Orthopedics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Musculoskeletal Disorders.
Background: Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated the use of baseline in-hospital DEXA screening to identify osteoporosis in ambulatory care and hospitalized patients; we also assessed specific risk factors for osteoporosis among these populations.
Methods: We included a baseline initial DEXA from 6406 consecutive patients at our tertiary referral University Hospital.
Results: Osteoporosis was diagnosed in 22.3% of the study population. In univariate analysis, osteoporosis risk factors were age, fracture history and low BMI (for all 3 sites), but also corticotherapy (lumbar spine and femoral neck) and male (lumbar spine). In multivariate analysis, age, fracture history, low BMI, and male increased osteoporosis risk. In-hospital screening yielded a higher percentage of osteoporosis positive scans than ambulatory care screening (31.8% vs 18.5%, p<0.001).In-hospital screening targeted an older and more predominantly male population with a higher fracture history. Z-scores revealed that this difference was not only due to an older age of the population and mainly concerned cortical bone.
Conclusions: In-hospital osteoporosis screening revealed more osteoporosis than screening in ambulatory practiceand could be an additional tool to improve the identification and management of osteoporosis. In addition to typical risk factors, we identified male as an osteoporosis risk factor in our cohort.
Figure 1
Figure 2