Identifies Immune-Related Gene Pair Signature Associated with Breast Cancer Prognosis

DOI: https://doi.org/10.21203/rs.3.rs-793025/v1

Abstract

Background: Breast cancer (BC) is the cancer with the largest number of deaths in women. There is growing evidence that immunity plays an important role in the prognosis of breast cancer.

Methods: In this study, we developed and validated an immune-related gene pair signature (IRGPs) to predict the survival of breast cancer patients. Screening immune-related genes from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database for the construction of IRGPs, and patients with breast cancer in these two cohorts were assigned to low- and high- risk subgroups. Additionally, we used Kaplan-Meier survival analysis, univariate and multivariate Cox analysis to investigate IRGPs and their individualized prognostic characteristics, and analysis of immune cell infiltration in breast cancer.

Results: A 47-IRGP signature was constructed from 2498 immune genes, which could significantly predict the overall survival (OS) of breast cancer patients in the TCGA and GEO cohorts. Immune infiltration analysis showed that a variety of immune cells are significantly related to the prognostic effects of IRGP characteristics in breast cancer patients, especially CD8+ T cells and macrophages.

Conclusions: The IRGP signature constructed in this study can help determine the prognosis of breast cancer and provide new ideas and basis for future research on the role of immune-related genes in breast cancer patients.

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