Newtonian inertia has initiated science centuries ago and dictates modern society with isolated logic systems. The hidden premise of this system is rigid existence in an isolated environment that defies any internal motion. The equivalent principle from general relativity and the T-symmetry reversible processes from thermodynamics also rely on such a notion. However, bio-inertia originates from the blind spots of this system; surface tension region inversion as the most general interactions is sacrificed for methodological isolation/test purposes and then neglected by science. We define and experiment bio-inertia as “parameter-against-gravity-recovery”, revealing the interaction between Planck regions and surface tension regions issues negentropy, conventional quantum collapse period is then extended to lifespan. This modulation which integrates quantum mechanics, gravitational waves, thermodynamics into surface tension bio quantum path duality needs to break the isolated logic method and takes musical inversion as structural dynamics in bio-systems, generalized as Basic Law of Evolution. An original evolutionary physical string oscillation memory equation is unveiled for the first time.