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Research
The Long-term Recovery of Parotid Glands and Oral QOL in Nasopharyngeal Cancer Treated by Intensity-modulated Radiotherapy
Keiichi Jingu
Department of Radiation Oncology, Tohoku University Graduate School of Medicine 1-1 Seiryo-chou, Aoba-ku, Sendai 980-8574, Japan
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7032-1577
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This work is licensed under a CC BY 4.0 License. Read Full License
Background
Xerostomia is one of the most common adverse events of radiotherapy in head and neck cancer patients. The purpose of this study was to evaluate longitudinal volume the change of parotid gland after radiotherapy for nasopharyngeal cancer and the relationship between parotid irradiation dose and xerostomia symptoms.
Methods
We retrospectively analyzed longitudinal changing of parotid gland volumes in 20 patients treated by intensity-modulated radiotherapy (IMRT). We assessed xerostomia 4 years or more after IMRT by measuring the degree of oral moisture and oral QOL evaluation.
Results
The relative parotid volumes at 0-6, 7-18, 19-30, 31-42, 43-54 and 55-66 months after IMRT were67.9 ± 10.1%, 67.7 ± 13.6%, 74.3 ± 12.5%, 75.8 ± 12.4%, 78.3 ± 17.4%, and 75.3% ± 17.7%, respectively. The parotid volume had recovered significantly at 31-42 months after IMRT, especially in parotid receiving less than 40 Gy. The mean irradiated dose for bilateral parotids showed negative correlations with oral QOL score and oral moisture.
Conclusion
The mean irradiated dose for the parotid should be reduce as much as possible to improve oral QOL long after IMRT.
Keywords
radiotherapy, parotid, IMRT, QOL, xerostomia
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This is a preprint. It has not completed peer review.
Research
The Long-term Recovery of Parotid Glands and Oral QOL in Nasopharyngeal Cancer Treated by Intensity-modulated Radiotherapy
Keiichi Jingu
Department of Radiation Oncology, Tohoku University Graduate School of Medicine 1-1 Seiryo-chou, Aoba-ku, Sendai 980-8574, Japan
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7032-1577
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 28 Sep, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Xerostomia is one of the most common adverse events of radiotherapy in head and neck cancer patients. The purpose of this study was to evaluate longitudinal volume the change of parotid gland after radiotherapy for nasopharyngeal cancer and the relationship between parotid irradiation dose and xerostomia symptoms.
Methods
We retrospectively analyzed longitudinal changing of parotid gland volumes in 20 patients treated by intensity-modulated radiotherapy (IMRT). We assessed xerostomia 4 years or more after IMRT by measuring the degree of oral moisture and oral QOL evaluation.
Results
The relative parotid volumes at 0-6, 7-18, 19-30, 31-42, 43-54 and 55-66 months after IMRT were67.9 ± 10.1%, 67.7 ± 13.6%, 74.3 ± 12.5%, 75.8 ± 12.4%, 78.3 ± 17.4%, and 75.3% ± 17.7%, respectively. The parotid volume had recovered significantly at 31-42 months after IMRT, especially in parotid receiving less than 40 Gy. The mean irradiated dose for bilateral parotids showed negative correlations with oral QOL score and oral moisture.
Conclusion
The mean irradiated dose for the parotid should be reduce as much as possible to improve oral QOL long after IMRT.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5