Demographics
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Male gender
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0.98[0.87–1.10];0.6878
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1.00[0.78–1.29];0.9898
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1.03[0.83–1.29];0.7733
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1.12[0.67–1.88];0.6546
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Female gender
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1.0[Reference]
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1.0[Reference]
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1.0[Reference]
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1.0[Reference]
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Baseline age, years
|
1.00[1.00-1.01];0.1533
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1.01[1.01–1.02];0.0016**
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1.01[1.00-1.01];0.2976
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1.00[0.98–1.02];0.9421
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< 40
|
1.0[Reference]
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1.0[Reference]
|
1.0[Reference]
|
1.0[Reference]
|
[40, 50)
|
1.02[0.85–1.22];0.8400
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0.72[0.46–1.12];0.1450
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1.07[0.73–1.56];0.7308
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0.96[0.39–2.38];0.9321
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[50–60)
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1.04[0.92–1.18];0.5569
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0.97[0.74–1.28];0.8386
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0.87[0.69–1.09];0.2345
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1.20[0.74–1.95];0.4528
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[60–70)
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1.02[0.91–1.14];0.7455
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1.05[0.82–1.35];0.6880
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0.98[0.81–1.19];0.8684
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0.71[0.45–1.11];0.1309
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[70–80)
|
0.98[0.85–1.12];0.7150
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1.19[0.91–1.57];0.2103
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1.16[0.92–1.47];0.2172
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1.13[0.66–1.96];0.6528
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>=80
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1.07[0.86–1.35];0.5366
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1.40[0.89–2.21];0.1436
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1.03[0.63–1.70];0.9074
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1.51[0.55–4.13];0.4210
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Past comorbidities
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|
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Charlson standard comorbidity index
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1.05[1.04–1.07];<0.0001***
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1.08[1.04–1.12];<0.0001***
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1.08[1.04–1.11];<0.0001***
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1.07[1.00-1.15];0.0589
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Hypertension
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1.20[1.02–1.40];0.0262*
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1.11[0.78–1.59];0.5645
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1.32[1.00-1.73];0.0481*
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1.18[0.61–2.29];0.6236
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Liver diseases
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1.24[1.04–1.47];0.0163*
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0.77[0.49–1.22];0.2689
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1.46[0.91–2.35];0.1148
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1.32[0.42–4.18];0.6381
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Hip fractures/accident falls
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1.26[0.96–1.64];0.0910
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1.98[1.21–3.23];0.0065**
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0.79[0.50–1.25];0.3174
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2.21[1.10–4.41];0.0253*
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Renal diseases
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1.02[0.88–1.19];0.7670
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1.06[0.77–1.48];0.7155
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1.05[0.79–1.39];0.7571
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1.24[0.67–2.29];0.4871
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Diabetes mellitus
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1.13[0.92–1.37];0.2369
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1.05[0.67–1.66];0.8204
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1.12[0.80–1.57];0.4963
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1.12[0.52–2.43];0.7733
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Maligt dysrhythmia
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2.09[1.12–3.89];0.0206*
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11.11[5.88–20.98];<0.0001***
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0.00[0.00-Inf];0.9877
|
0.00[0.00-Inf];0.9946
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Chronic obstructive pulmonary disease
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1.42[0.78–2.56];0.2515
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1.83[0.59–5.72];0.2971
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2.04[0.84–4.94];0.1133
|
5.51[1.34–22.64];0.0179*
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Ischemic heart disease
|
0.98[0.72–1.34];0.8984
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1.30[0.69–2.44];0.4160
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0.98[0.49–1.98];0.9639
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0.70[0.10–5.07];0.7271
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Peripheral vascular disease
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1.10[0.57–2.12];0.7774
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1.93[0.62–6.03];0.2570
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0.87[0.22–3.51];0.8502
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2.51[0.35–18.07];0.3611
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Endocrine diseases
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1.04[0.93–1.18];0.4907
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0.76[0.58-1.00];0.0538
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1.04[0.84–1.29];0.7304
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0.75[0.44–1.28];0.2934
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Gastrointestinal diseases
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1.03[0.92–1.17];0.5810
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0.94[0.73–1.21];0.6327
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1.22[0.93–1.59];0.1534
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1.71[0.85–3.41];0.1296
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Stroke/transient ischemic attack
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1.11[0.85–1.46];0.4279
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1.02[0.54–1.92];0.9477
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1.48[0.91–2.40];0.1149
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0.96[0.24–3.92];0.9586
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Hospitalization
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Average readmission
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1.000[1.000–1.000];0.2724
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0.998[0.997-1.000];0.0625
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1.000[1.000-1.001];0.0823
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0.99[0.98-1.00];0.0080**
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Total episode number
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0.95[0.95–0.96];<0.0001***
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0.96[0.95–0.97];<0.0001***
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0.96[0.95–0.97];<0.0001***
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0.97[0.95–0.99];0.0050**
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Overall hospital stay, days
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1.001[0.999–1.002];0.3779
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1.001[0.999–1.004];0.3117
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1.00[1.00-1.01];0.0004***
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1.01[1.00-1.01];0.0040**
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Medications
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PD-L1 v.s. PD-1
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0.77[0.64–0.93];0.0078**
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0.32[0.18–0.59];0.0002***
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0.80[0.65-1.00];0.0463*
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0.34[0.18–0.65];0.0010**
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PD-L1 expenditure, HKD
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1.000[1.000–1.000];<0.0001***
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1.000[1.000–1.000];0.0528
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1.000[1.000–1.000];<0.0001***
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1.000[1.000–1.000];0.0528
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Total PD-L1 dose amount, mg
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1.000[1.000–1.000];0.0703
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1.000[1.000–1.000];0.2410
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1.000[1.000–1.000];0.0703
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1.000[1.000–1.000];0.2410
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PD-L1 inhibitors duration, days
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1.00[0.99-1.00];<0.0001***
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0.99[0.99-1.00];0.0263*
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1.00[0.99-1.00];<0.0001***
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0.99[0.99-1.00];0.0263*
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PD-1 expenditure
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1.000[1.000–1.000];<0.0001***
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1.000[1.000–1.000];<0.0001***
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1.000[1.000–1.000];<0.0001***
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1.000[1.000-1.001];0.0018**
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Total PD-1 dose amount (MG)
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1.000[1.000–1.000];<0.0001***
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1.000[1.000–1.000];0.1842
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1.000[1.000–1.000];0.0008***
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1.000[1.000–1.000];0.0958
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PD-1 inhibitors duration, days
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0.997[0.997–0.998];<0.0001***
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0.998[0.997–0.998];<0.0001***
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0.998[0.997–0.998];<0.0001***
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0.998[0.997–0.999];0.0007***
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Anticoagulants
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0.81[0.73–0.91];0.0002***
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0.73[0.58–0.93];0.0097**
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0.89[0.74–1.08];0.2423
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0.78[0.50–1.20];0.2574
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Steroids
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0.81[0.73–0.91];0.0002***
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0.73[0.58–0.93];0.0097**
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0.89[0.74–1.08];0.2423
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0.78[0.50–1.20];0.2574
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Inflammatory subclinical biomarkers
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Neutrophil-to-lymphocyte ratio
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1.01[1.00-1.01];0.0296*
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1.00[0.98–1.02];0.8231
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1.01[1.00-1.02];0.1025
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0.97[0.92–1.03];0.3646
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Platelet-to-lymphocyte ratio
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1.000[1.000–1.000];0.0261*
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1.000[1.000-1.001];0.5907
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1.000[1.000–1.000];0.1087
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1.000[0.999–1.001];0.9257
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Aspartate transaminase-to-alanine transaminase ratio
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1.03[1.01–1.04];<0.0001***
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1.01[0.97–1.06];0.6492
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1.09[1.04–1.14];0.0004***
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0.96[0.71–1.29];0.7683
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Triglyceride glucose index
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0.97[0.83–1.13];0.6770
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0.59[0.41–0.85];0.0040**
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0.85[0.66–1.09];0.2061
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0.55[0.30–1.02];0.0594
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Urea-to-creatinine ratio
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1.000[0.999–1.001];0.9657
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1.000[0.997–1.002];0.9081
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1.00[1.00-1.01];0.2003
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1.01[1.00-1.01];0.0007***
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Monocyte-to-lymphocyte ratio
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1.07[0.99–1.16];0.0998
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0.99[0.79–1.23];0.9303
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1.20[1.02–1.43];0.0305*
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1.07[0.69–1.67];0.7559
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Complete blood counts
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Mean corpuscular volume, fL
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1.00[0.99–1.01];0.9942
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1.01[1.00-1.03];0.1496
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1.00[0.98–1.01];0.5845
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1.03[1.00-1.07];0.0470*
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Eosinophil, x10^9/L
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0.74[0.58–0.93];0.0105*
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0.84[0.54–1.31];0.4333
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0.81[0.53–1.23];0.3143
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1.14[0.49–2.64];0.7632
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Lymphocyte, x10^9/L
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0.98[0.92–1.05];0.6221
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1.08[0.97–1.20];0.1514
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0.96[0.83–1.10];0.5296
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1.07[0.78–1.47];0.6699
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Metamyelocyte, x10^9/L
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0.87[0.70–1.07];0.1830
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0.78[0.46–1.31];0.3392
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0.71[0.40–1.28];0.2549
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0.74[0.21–2.63];0.6383
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Monocyte, x10^9/L
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1.24[1.06–1.45];0.0078**
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1.23[0.87–1.73];0.2362
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1.51[1.14-2.00];0.0045**
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1.65[0.88–3.11];0.1194
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Neutrophil, x10^9/L
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1.02[1.01–1.04];0.0013**
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1.01[0.98–1.05];0.4025
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1.03[1.01–1.06];0.0129*
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1.02[0.96–1.08];0.5817
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White blood count, x10^9/L
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1.02[1.01–1.03];<0.0001***
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1.02[1.00-1.05];0.1069
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1.03[1.00-1.05];0.0187*
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1.02[0.97–1.08];0.4938
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Mean cell haemoglobin, pg
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0.99[0.97–1.01];0.2267
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1.01[0.97–1.05];0.6190
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0.96[0.94–0.99];0.0133*
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1.05[0.97–1.14];0.1981
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Myelocyte, x10^9/L
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0.93[0.84–1.02];0.1131
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0.88[0.66–1.18];0.3893
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0.83[0.66–1.04];0.1098
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0.83[0.50–1.39];0.4823
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Platelet, x10^9/L
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1.001[1.000-1.001];0.0388*
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1.001[1.000-1.002];0.2819
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1.002[1.001–1.003];0.0015**
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1.002[0.999–1.004];0.1452
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Red blood count, x10^12/L
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0.93[0.86–1.01];0.0818
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0.93[0.78–1.10];0.3688
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0.91[0.79–1.06];0.2409
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1.26[0.89–1.78];0.1925
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Hematocrit, L/L
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0.30[0.11–0.80];0.0163*
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0.75[0.09–6.67];0.7997
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0.18[0.03–1.13];0.0671
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566.25[4.88-65751.46];0.0090**
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Renal and liver functions
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K/Potassium, mmol/L
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0.91[0.80–1.03];0.1211
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1.03[0.79–1.35];0.8120
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0.87[0.69–1.09];0.2157
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0.92[0.56–1.52];0.7440
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Urate, mmol/L
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1.54[0.72–3.30];0.2671
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5.04[0.95–26.62];0.0570
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1.71[0.32–9.18];0.5314
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0.65[0.02–19.52];0.8040
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Albumin, g/L
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0.97[0.96–0.98];<0.0001***
|
0.98[0.96-1.00];0.0540
|
0.98[0.96–0.99];0.0061**
|
1.04[0.99–1.09];0.1011
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Na/Sodium, mmol/L
|
0.97[0.96–0.98];<0.0001***
|
0.97[0.95-1.00];0.0227*
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0.95[0.92–0.97];0.0001***
|
0.97[0.91–1.05];0.4786
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Urea, mmol/L
|
0.99[0.97–1.02];0.5540
|
1.02[0.98–1.06];0.4164
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0.98[0.93–1.03];0.4672
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1.00[0.89–1.13];0.9939
|
Protein, g/L
|
0.99[0.99-1.00];0.0001***
|
1.00[0.99–1.01];0.8901
|
0.99[0.99-1.00];0.0087**
|
1.00[0.98–1.02];0.9227
|
Bilirubin, umol/L
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1.003[1.002–1.005];<0.0001***
|
1.00[1.00-1.01];0.5730
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1.00[1.00-1.01];0.9330
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1.00[0.99–1.01];0.9730
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Creatinine, umol/L
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1.001[1.000-1.001];0.2210
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1.000[0.998–1.002];0.7707
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1.001[0.999–1.002];0.2969
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1.00[0.99-1.00];0.4195
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SD of creatinine
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1.001[1.000-1.001];0.0001***
|
1.001[1.000-1.002];0.0719
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1.001[1.000-1.001];0.0974
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1.000[0.998–1.002];0.7760
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Aspartate transaminase, U/L
|
1.001[1.001–1.001];<0.0001***
|
1.000[0.998–1.002];0.8846
|
1.001[0.999–1.002];0.4383
|
0.99[0.98–1.01];0.2798
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SD of aspartate transaminase
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1.001[1.000-1.001];<0.0001***
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1.000[1.000-1.001];0.2117
|
1.001[1.000-1.002];0.0155*
|
1.001[0.997–1.004];0.6500
|
Alkaline phosphatase, U/L
|
1.001[1.001–1.002];<0.0001***
|
1.000[0.999–1.002];0.7097
|
1.000[0.999–1.001];0.4551
|
1.00[0.99-1.00];0.2454
|
SD of alkaline phosphatase
|
1.002[1.002–1.003];<0.0001***
|
1.002[1.001–1.003];0.0014**
|
1.003[1.002–1.003];<0.0001***
|
1.002[1.000-1.004];0.0359*
|
Alanine transaminase, U/L
|
1.000[1.000-1.001];0.3737
|
1.000[0.998–1.002];0.8684
|
0.999[0.995–1.002];0.3897
|
0.99[0.98-1.00];0.0914
|
SD of alanine transaminase
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1.001[1.001–1.002];<0.0001***
|
1.001[1.000-1.002];0.0177*
|
1.001[1.000-1.003];0.0741
|
1.00[0.99-1.00];0.5347
|
Lipid, iron and calcium profile
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|
|
|
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Total iron-binding capacity, L
|
1.00[0.98–1.02];0.9971
|
1.00[0.95–1.05];0.9678
|
0.99[0.95–1.04];0.7518
|
3.87[0.00-Inf];0.9993
|
VitaminB12, pmol/L
|
0.999[0.998-1.000];0.1739
|
1.00[0.99-1.00];0.1813
|
1.000[0.998–1.002];0.7853
|
1.00[0.99–1.01];0.8806
|
Folate, ng/mL
|
1.00[0.97–1.03];0.9877
|
1.04[0.97–1.12];0.2752
|
1.00[0.96–1.05];0.8835
|
1.04[0.95–1.14];0.3791
|
Ferritin, pmol/L
|
1.000[1.000–1.000];0.4438
|
1.000[1.000–1.000];0.3647
|
1.000[1.000–1.000];0.2525
|
1.000[1.000-1.001];0.1003
|
Calcium, mmol/L
|
0.64[0.39–1.06];0.0826
|
0.41[0.13–1.26];0.1212
|
0.91[0.36–2.28];0.8345
|
1.40[0.20–9.84];0.7350
|
SD of calcium
|
12.70[5.21–30.97];<0.0001***
|
2.10[0.13–34.34];0.6015
|
4.69[1.00-22.02];0.0499*
|
2.32[0.04-132.03];0.6840
|
Phosphate, mmol/L
|
0.83[0.59–1.18];0.3059
|
0.79[0.36–1.74];0.5548
|
0.98[0.50–1.90];0.9464
|
0.61[0.14–2.69];0.5115
|
SD of phosphate
|
5.97[3.23–11.04];<0.0001***
|
7.44[1.81–30.57];0.0054**
|
3.91[0.74–20.76];0.1098
|
18.22[0.41-815.46];0.1345
|
Inorganic, mmol/L
|
1.01[1.00-1.03];0.0836
|
0.99[0.94–1.04];0.7433
|
1.04[1.01–1.08];0.0055**
|
0.97[0.84–1.13];0.7058
|
SD of inorganic
|
1.00[0.95–1.07];0.8984
|
0.98[0.82–1.17];0.8125
|
1.08[0.85–1.36];0.5374
|
0.09[0.00-21.93];0.3871
|
Glycemic and clotting profile
|
|
|
|
|
Triglyceride, mmol/L
|
0.96[0.88–1.05];0.3264
|
0.74[0.56–0.99];0.0436*
|
0.90[0.78–1.04];0.1556
|
0.61[0.35–1.09];0.0933
|
SD of triglyceride
|
0.84[0.64–1.11];0.2196
|
0.20[0.04–1.02];0.0526
|
0.69[0.41–1.17];0.1655
|
0.54[0.08–3.53];0.5213
|
Glucose, mmol/L
|
1.02[0.99–1.04];0.1738
|
1.00[0.94–1.05];0.9179
|
0.99[0.95–1.03];0.5861
|
0.90[0.79–1.04];0.1558
|
SD of glucose
|
1.06[1.02–1.11];0.0032**
|
1.07[0.98–1.16];0.1337
|
1.07[1.00-1.14];0.0580
|
1.07[0.92–1.23];0.3816
|
HbA1c, g/dL
|
0.97[0.95-1.00];0.0539
|
1.00[0.94–1.06];0.9969
|
0.95[0.91-1.00];0.0543
|
1.19[1.05–1.34];0.0072**
|
SD of HbA1c
|
1.58[1.44–1.74];<0.0001***
|
1.51[1.23–1.85];0.0001***
|
1.52[1.29–1.79];<0.0001***
|
1.94[1.36–2.76];0.0003***
|
High sensitive troponin-I, ng/L
|
1.000[1.000–1.000];0.9239
|
1.000[1.000–1.000];0.1181
|
1.000[1.000–1.000];0.9382
|
1.000[1.000-1.001];0.1785
|
SD of high sensitive troponin-I
|
1.000[1.000–1.000];0.7182
|
1.000[1.000–1.000];0.0044**
|
1.000[0.999–1.001];0.9978
|
1.000[1.000-1.001];0.2563
|
APTT, second
|
1.01[1.00-1.03];0.1426
|
0.98[0.93–1.03];0.3733
|
0.99[0.95–1.03];0.6325
|
0.98[0.89–1.08];0.6750
|
SD of APTT
|
1.05[1.02–1.08];0.0006***
|
0.99[0.90–1.10];0.8880
|
1.01[0.90–1.13];0.8927
|
1.10[0.86–1.42];0.4432
|
Lactate dehydrogenase, U/L
|
1.000[1.000–1.000];<0.0001***
|
1.000[1.000-1.001];0.0165*
|
1.000[1.000-1.001];0.0001***
|
1.000[0.999–1.001];0.6208
|
SD of lactate dehydrogenase
|
1.000[1.000–1.000];<0.0001***
|
1.000[1.000-1.001];0.0229*
|
1.002[1.001–1.002];<0.0001***
|
1.002[1.000-1.003];0.0056**
|
Total cholesterol, mmol/L
|
0.98[0.90–1.07];0.6769
|
0.92[0.75–1.13];0.4335
|
1.05[0.90–1.22];0.5598
|
1.42[1.00–2.00];0.0490*
|
SD of total cholesterol
|
1.14[0.84–1.55];0.3905
|
0.93[0.42–2.07];0.8677
|
1.23[0.73–2.07];0.4394
|
2.73[0.81–9.19];0.1058
|
Low-density lipoprotein, mmol/L
|
1.00[0.90–1.11];0.9905
|
0.96[0.76–1.22];0.7514
|
1.14[0.96–1.37];0.1398
|
1.67[1.14–2.45];0.0091**
|
SD of low-density lipoprotein
|
1.22[0.84–1.78];0.2952
|
1.13[0.45–2.83];0.7919
|
1.66[0.77–3.55];0.1928
|
7.64[1.84–31.77];0.0051**
|
High-density lipoprotein, mmol/L
|
0.93[0.73–1.19];0.5774
|
1.27[0.77–2.11];0.3530
|
0.97[0.62–1.50];0.8772
|
1.96[0.82–4.71];0.1309
|
SD of high-density lipoprotein
|
2.42[0.85–6.87];0.0971
|
1.55[0.11–21.84];0.7461
|
1.32[0.19–9.12];0.7758
|
1.09[0.01-164.28];0.9719
|