As observed in the presented results, in guinea pigs the mucous pyloric glands display a high activity by synthetizing neutral, but also acid mucosubstances. Oppositely, the secretory activity of the mucous cells in the Bruner glands is modest.
In the case of chinchillas, the situation is reversed, that is a negligible secretion of mucosubstances in the pyloric glands, and a significantly higher mucous content in the Bruner glands (i.e., for the both categories of mucosubstances). In other words, there appears to be a functional bond between the two types of glands (pyloric and Bruner glands). It seems one completes the secretion of the other. In this sense, if the amount of mucus synthesized by the cells in the pyloric area is high, it will be supplemented with small quantities from the Bruner glands, and vice versa. In the case of the two rodents described, the pyloric glands are more active in guinea pigs, whereas the Bruner glands are significantly more dynamic in chinchillas.
Some comparative data regarding the mucins secreted by the Brunner’s glands and the duodenal goblet cells in the chinchilla, guinea-pig and the house mouse were provided by some authors [7, 8]. In the guinea-pig, the goblet cells from the duodenum display a mucous content with sialic acid and N-acetylgalactosamine subterminal to sulfated groups. As a comparison, in the same species, the Brunner’s glands produce class-III stable sulfosialomucins. However, the Brunner’s glands of the mouse produce class-III stable neutral mucins that are binding to the same lectins as the ones observed in the guinea-pig, not including those specific to sialic acid. In contrast to Brunner’s glands, in the mouse, the duodenal goblet cells do not have stable class-III mucins and present tiny amounts of sialic acid [7, 9].
The species analyzed in this study (i.e., guinea-pig and chinchilla) are frequently used as a comparative model in a series of experiments. Among the main topics assessed worldwide is the infection with Helicobacter pylori and H. spp.,, including the efficacy of some new therapies. The distribution efficiency of the antibiotic agents through the mucous layer of the stomach, where H. pylori resides, has been unexpectedly little studied. Since H. pylori is becoming more refractory to standard antibiotics, there is a necessity to point out the essential mechanisms that may interfere with the delivery of the antibiotic in the stomach, so as to help the design of some new therapeutic agents. The gastric mucous layer, whose purpose is to protect the gastric mucosal epithelium from injurious agents/substances, may also act as obstacle to antibiotic penetration. Accordingly, some mucolytic agents were utilized with good effects to improve the penetration rates throughout the gastric mucous layer. In view of that, a better understanding of the main peculiarities of the digestive tract in the species used as a comparative model is more than welcome [10, 11].