Background and aims
The dyslipidemia contributed to more than half Cardiovascular disease (CVD) which ranked first in all causes of death in the world. Children’s lipid accumulation product (CLAP) is significantly related to cardiac metabolic risk factors in children and adolescents. The present study was to explore a novel indicator of children’s lipid accumulation product (CLAP) associated with dyslipidemia in Chinese children and adolescents.
A total of 683 children and adolescents aged 8-15 years were recruited using the stratified cluster sampling method in this cross-sectional study, and were measured their body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic curve (ROC curve) were used to compare the effects of CLAP for predicting dyslipidemia.
The prevalence of dyslipidemia was 13.6% (13.9% in boys and 13.2% in girls). The AUC (95%CI) of CLAP for predicting dyslipidemia was 0.76 (0.66-0.84) in girls, was 0.83 (0.76-0.89) in boys, and was higher than those of Sweight, SWC, SAST, SWHtR, and SBMI, respectively. The P85 of CLAP was the optimal value to predict dyslipidemia among girls (OR (95% CI): 10.54(5.09-21.82), AUC (95% CI): 0.72 (0.62-0.81). The P75 of CLAP was the optimal value to predict dyslipidemia among boys (OR (95% CI): 8.74(4.54-16.85), AUC (95% CI): 0.73 (95% CI 0.65-0.81).
The CLAP was a novel indicator associated with dyslipidemia in Chinese children and adolescents, and performed better than weight, WC, AST, WHtR, and BMI.