This study was supported by grants from Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2019-I2M-5-029), Beijing Municipal Committee of Science and Technology (Z201100005620010), National Key R&D Program of China (2018YFC1312903), the National Natural Science Foundation of China (81870905), and Beijing Municipal Science & Technology Commission (D171100003017002).
Availability of data and materials
Due to CSCA project regulations, data that support the findings of this study is not publicly available. If someone wants to request the data, please contact the investigators of the Beijing tiantan hospital with reasonable request.
Ethics approval and consent to participate
The study was approved by the Chinese Stroke Center Alliance, the Beijing Tiantan hospital Ethics Committee (the ethical reference number is KY 2018-061- 02) in accordance with the Declaration of Helsinki. All methods were carried out in accordance with relevant guidelines and regulations. Participating hospitals received a healthcare quality assessment and research approval to collect data in the CSCA without requiring individual patient informed consent under the common rule or a waiver of authorization and exemption from their Institutional Review Board. Patient informed consent was waived by the Beijing Tiantan hospital Ethics Committee. Patient confidentiality will be protected in the following ways:(1) data are stripped of all identifiers before their use in research and (2) the use of data for these purposes is closely overseen by the China National Clinical Research Center for Neurological Diseases analytic center.
Consent for publication
Disclosure of conflicts of interest
The authors declare no financial or other conflicts of interest.
ZhaoXL, ZiXL, YJW and XQZ planned and designed the study. HQG and QZ analyzed the data. ZhaoXL wrote the paper. ZiXL and XQZ revised the paper.
1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2 China National Clinical Research Center for Neurological Diseases, Beijing, China.
3 Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
4 Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
5 Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China
List of directors of Provincial Centers of Neurological Diseases/Stroke Care Management
1．Anhui: Kai Wang, Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
2．Beijing: Xunming Ji, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
3．Chongqing: Xinyue Qin, Department of Neurology, the First Affiliated hospital of Chongqing Medical University, Chongqing, China.
4．Fujian: Ning Wang, Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China.
5．Gansu: Zhaoming Ge, Department of Neurology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
6．Guangdong: Jinsheng Zeng, Department of neurology, National Key Clinical Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
7．Guangxi: Lvli Li, Department of Neurology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
8．Guizhou: Lan Chu, Department of Neurology, Hospital Of Guizhou Medical University, Guiyang, Guizhou, China.
Hainan: Zhibin Chen, Department of Neurology, the First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
9．Hebei: Li Guo, Department of Neurology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Heilongjiang: Guozhong Li, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
10．Henan: Yuming Xu, Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Henan, China.
11．Hubei: Bo Hu, Department of Neurology, Union Hospital, Hua Zhong Science and Technology University, Wuhan, Hubei, China.
12．Hunan: Beisha Tang, Department of Neurology and Gerontology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
13．Inner Mongolia: Guorong Liu, Depertment of Neurology, Baotou City Central Hospital（Inner Mongolia CVD Institute）, Baotou, Inner Mongolia, China.
14．Jiangsu: Xiaoshan Wang, Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
15．Jiangxi: Xiaomu Wu, Department of Neurology, Jiangxi Provincial People’s Hospital, Nanchang, Jiangxi, China.
16．Jilin: Yi Yang, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin, China.
17．Liaoning: Zhiyi He, Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
18．Ningxia: Zhenhai Wang, Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
19．Qing Hai: Shizheng Wu, Department of Neurology, Qinghai Provincial People’s Hospital, Xining, Qinghai, China.
20．Shaanxi: Gang Zhao, Department of Neurology, Xijing Hospital, the Fourth Military Medical University, Xian, Shaanxi, China.
21．Shandong: Meijia Zhu, Department of Neurology, Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
22．Shanghai: Qiang Dong, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
23．Shanxi: Xiaoyuan Niu, Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
24．Sichuan: Dong Zhou, Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
25．Tianjin: Zhongping An, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
26．Tibet: Yuhua Zhao, Department of Neurology, the People’s Hospital of Tibetan Autonomous Region, Lhasa, Tibet, China.
27．Xinjiang: Xiaoning Zhang, Department of Neurology, the Fourth Affiliation Hospital, Xinjiang Medical University, Urumuqi, Xinjiang, China.
28．Yunnan: Li Ding, Department of Neurology, the First People’s Hospital of Yunnan Province, Kunming, Yunnan, China.
29．Zhejiang: Min Lou, Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.