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Research article
Xiaofeng Yang
The First Affiliated Hospital of Xi'an Jiaotong University
Corresponding Author
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Background Blood flow in the corpus luteum is associated with luteal function. However, the impact of luteal blood flow on the Methotrexate(MTX) treatment in women with unruptured tubal pregnancy has not been reported. The aim of the present study was to observe the impact of luteal blood flow on therapeutic effect of MTX in women with unruptured tubal pregnancy.
Methods A prospective study recruited 129 women with unruptured tubal pregnancy in the First Affiliated Hospital of Xi’an Jiaotong University from September 2016 to June 2018. One hundred and fifteen participants were treated successfully with MTX, and women were divided into 2 groups according to the luteal blood flow, included poor luteal blood flow group and rich luteal blood flow group. The therapeutic effect were compared between the two groups.
Results Women in rich luteal blood flow group had a significantly higher serum β-human chorionic gonadotropin(β-hCG) level 4 days,1 week and 2 weeks after MTX treatment compared with women in poor luteal blood flow group( P <0.05).The average diameter of ectopic mass 1 week,2 weeks and 3 weeks after MTX treatment in women with rich luteal blood flow were significantly bigger( P <0.05),and the time of serum β-hCG clearance and ectopic mass disappearance were significantly longer compared with women in poor luteal blood flow group( P <0.05).
Conclusions Luteal blood flow might be as a predictive factor for MTX treatment outcome in women with unruptured tubal pregnancy, and those with rich luteal blood flow needed longer recovery time.
Keywords
Luteal blood flow, Methotrexate, Unruptured tubal pregnancy, Predictive factor
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CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Editorial decision: Accept
On 18 Mar, 2020
Editor assigned
On 16 Mar, 2020
Submission checks complete
On 15 Mar, 2020
Editor invited
On 15 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 12 Mar, 2020
Reviewer #2 agreed
On 10 Mar, 2020
Review #2 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 06 Mar, 2020
Review #1 received
Received 06 Mar, 2020
Reviewers invited
Invitations sent on 05 Mar, 2020
Editor assigned
On 26 Feb, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
Version 1
Posted 02 Dec, 2019
No comments provided
Editorial decision: Major revision
On 18 Feb, 2020
Review #1 received
Received 10 Jan, 2020
Review #2 received
Received 10 Jan, 2020
Reviewer #2 agreed
On 08 Jan, 2020
Reviewer #1 agreed
On 15 Dec, 2019
Reviewers invited
Invitations sent on 12 Dec, 2019
Submission checks complete
On 28 Nov, 2019
Editor assigned
On 23 Oct, 2019
Editor invited
On 22 Oct, 2019
First submitted
On 21 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
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A new preprint design is coming!
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See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Xiaofeng Yang
The First Affiliated Hospital of Xi'an Jiaotong University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Editorial decision: Accept
On 18 Mar, 2020
Editor assigned
On 16 Mar, 2020
Submission checks complete
On 15 Mar, 2020
Editor invited
On 15 Mar, 2020
No comments provided
Editorial decision: Minor revision
On 12 Mar, 2020
Reviewer #2 agreed
On 10 Mar, 2020
Review #2 received
Received 10 Mar, 2020
Reviewer #1 agreed
On 06 Mar, 2020
Review #1 received
Received 06 Mar, 2020
Reviewers invited
Invitations sent on 05 Mar, 2020
Editor assigned
On 26 Feb, 2020
Submission checks complete
On 26 Feb, 2020
Editor invited
On 25 Feb, 2020
Version 1
Posted 02 Dec, 2019
No comments provided
Editorial decision: Major revision
On 18 Feb, 2020
Review #1 received
Received 10 Jan, 2020
Review #2 received
Received 10 Jan, 2020
Reviewer #2 agreed
On 08 Jan, 2020
Reviewer #1 agreed
On 15 Dec, 2019
Reviewers invited
Invitations sent on 12 Dec, 2019
Submission checks complete
On 28 Nov, 2019
Editor assigned
On 23 Oct, 2019
Editor invited
On 22 Oct, 2019
First submitted
On 21 Oct, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background Blood flow in the corpus luteum is associated with luteal function. However, the impact of luteal blood flow on the Methotrexate(MTX) treatment in women with unruptured tubal pregnancy has not been reported. The aim of the present study was to observe the impact of luteal blood flow on therapeutic effect of MTX in women with unruptured tubal pregnancy.
Methods A prospective study recruited 129 women with unruptured tubal pregnancy in the First Affiliated Hospital of Xi’an Jiaotong University from September 2016 to June 2018. One hundred and fifteen participants were treated successfully with MTX, and women were divided into 2 groups according to the luteal blood flow, included poor luteal blood flow group and rich luteal blood flow group. The therapeutic effect were compared between the two groups.
Results Women in rich luteal blood flow group had a significantly higher serum β-human chorionic gonadotropin(β-hCG) level 4 days,1 week and 2 weeks after MTX treatment compared with women in poor luteal blood flow group( P <0.05).The average diameter of ectopic mass 1 week,2 weeks and 3 weeks after MTX treatment in women with rich luteal blood flow were significantly bigger( P <0.05),and the time of serum β-hCG clearance and ectopic mass disappearance were significantly longer compared with women in poor luteal blood flow group( P <0.05).
Conclusions Luteal blood flow might be as a predictive factor for MTX treatment outcome in women with unruptured tubal pregnancy, and those with rich luteal blood flow needed longer recovery time.
Figure 1
Figure 2
Figure 3
Figure 4
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