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Research article
Effect of rTMS on Parkinson's Cognitive Function: A Systematic Review and Meta-analysis
Qiwen Mu
Guangdong Hospital of Traditional Chinese Medicine
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Neurology.
Background: To evaluate the effects and optimal parameters of repetitive transcranial magnetic stimulation (rTMS) on cognition function of Parkinson's disease (PD) patients and to estimate which cognitive function may obtain more benefits from rTMS.
Method: The articles dealing with rTMS on cognition of PD patients were retrieved from the databases until April 2019. Two researchers selected research papers, evaluated their quality, extracted data, and cross-checked them according to the inclusion and exclusion criteria. The standardized mean differences (SMDs) with 95 % confidence interval (CI) of cognitive outcome for different parameters, scales, and cognitive functions were estimated.
Results: Fourteen studies involving 173 subjects were included in the study. A significant effect size was observed with the mini-mental state examination (MMSE) for the global cognitive outcome based on the evidence of four published articles. Further subtests for different cognitive domains demonstrated prominent effect for the executive function. The significant effect sizes for executive function were found with multiple sessions of high-frequency rTMS over frontal cortex, especially over dorsolateral prefrontal cortex (DLPFC). All of the other cognitive domains including memory, attention, and language ability did not obtain significant effects.
Conclusions: Multiple sessions of high-requency rTMS over the DLPFC may have positive effect on executive function in PD patients. Further well designed studies with large sample sizes are needed to verify our results and ascertain the long-term effects of rTMS.
Keywords
Transcranial magnetic stimulation, Parkinson, Cognitive deficit, Executive function
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CURRENT STATUS: Published
Version 2
Posted 17 Apr, 2020
Published
On 19 Oct, 2020
No community comments so far
Editorial decision: Major revision
On 15 May, 2020
Review #3 received
Received 09 May, 2020
Review #1 received
Received 03 May, 2020
Review #2 received
Received 03 May, 2020
Reviewer #3 agreed
On 23 Apr, 2020
Reviewer #1 agreed
On 19 Apr, 2020
Reviewer #2 agreed
On 19 Apr, 2020
Editor assigned
On 14 Apr, 2020
Reviewers invited
Invitations sent on 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
No comments provided
Review #3 received
Received 11 Mar, 2020
Editorial decision: Major revision
On 11 Mar, 2020
Reviewer #3 agreed
On 02 Mar, 2020
Review #2 received
Received 28 Feb, 2020
Review #1 received
Received 26 Jan, 2020
Reviewer #2 agreed
On 06 Jan, 2020
Reviewer #1 agreed
On 10 Dec, 2019
Reviewers invited
Invitations sent on 05 Dec, 2019
Editor assigned
On 27 Nov, 2019
First submitted
On 26 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
Metrics
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Subject Areas
Neurology
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This preprint is under consideration at BMC Neurology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Effect of rTMS on Parkinson's Cognitive Function: A Systematic Review and Meta-analysis
Qiwen Mu
Guangdong Hospital of Traditional Chinese Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 17 Apr, 2020
Published
On 19 Oct, 2020
No community comments so far
Editorial decision: Major revision
On 15 May, 2020
Review #3 received
Received 09 May, 2020
Review #1 received
Received 03 May, 2020
Review #2 received
Received 03 May, 2020
Reviewer #3 agreed
On 23 Apr, 2020
Reviewer #1 agreed
On 19 Apr, 2020
Reviewer #2 agreed
On 19 Apr, 2020
Editor assigned
On 14 Apr, 2020
Reviewers invited
Invitations sent on 14 Apr, 2020
Submission checks complete
On 13 Apr, 2020
Editor invited
On 13 Apr, 2020
No comments provided
Review #3 received
Received 11 Mar, 2020
Editorial decision: Major revision
On 11 Mar, 2020
Reviewer #3 agreed
On 02 Mar, 2020
Review #2 received
Received 28 Feb, 2020
Review #1 received
Received 26 Jan, 2020
Reviewer #2 agreed
On 06 Jan, 2020
Reviewer #1 agreed
On 10 Dec, 2019
Reviewers invited
Invitations sent on 05 Dec, 2019
Editor assigned
On 27 Nov, 2019
First submitted
On 26 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Neurology.
Background: To evaluate the effects and optimal parameters of repetitive transcranial magnetic stimulation (rTMS) on cognition function of Parkinson's disease (PD) patients and to estimate which cognitive function may obtain more benefits from rTMS.
Method: The articles dealing with rTMS on cognition of PD patients were retrieved from the databases until April 2019. Two researchers selected research papers, evaluated their quality, extracted data, and cross-checked them according to the inclusion and exclusion criteria. The standardized mean differences (SMDs) with 95 % confidence interval (CI) of cognitive outcome for different parameters, scales, and cognitive functions were estimated.
Results: Fourteen studies involving 173 subjects were included in the study. A significant effect size was observed with the mini-mental state examination (MMSE) for the global cognitive outcome based on the evidence of four published articles. Further subtests for different cognitive domains demonstrated prominent effect for the executive function. The significant effect sizes for executive function were found with multiple sessions of high-frequency rTMS over frontal cortex, especially over dorsolateral prefrontal cortex (DLPFC). All of the other cognitive domains including memory, attention, and language ability did not obtain significant effects.
Conclusions: Multiple sessions of high-requency rTMS over the DLPFC may have positive effect on executive function in PD patients. Further well designed studies with large sample sizes are needed to verify our results and ascertain the long-term effects of rTMS.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6