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Research article
Xiaoyun Xiong
Corresponding Author
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Background: To examine the dose effect of maternal milk (MM) feeding on neonatal necrotizing enterocolitis (NEC) development.
Methods: This retrospective study included 305 infants [birth weight<1 500 g, or gestation age (GA)<32 weeks]. Curve estimation was performed to evaluate the dose relationship between MM proportion and NEC. Then infants were grouped based on curve trend and multivariable regression analysis was conducted to prove the curve estimation.
Results: Rate of NEC for the sample was 7.9% and age at onset was 25.6(16.0–26.0) days. The curve showed that when MM proportion was increased from zero to 20%, rate of NEC increased from 25% to 40% at first and when MM from 20% to 100%, rate dropped from 40% to near zero. In the MM proportion from zero to 40%, rate of NEC changed greatly. The multiple regression analysis showed that compared with MM proportion >0.70, 0.4<MM proportion £0.7 was associated with a 5.482- fold higher odds of developing NEC（P=0.032）; 0<MM proportion £0.4 was a 24.99-fold increase in the odds of developing NEC（P<0.001）; MM proportion =0 was a 9.348-fold increase in the odds of developing NEC（P=0.003）.
Conclusion: This study estimated how rate of NEC changed with MM proportion increase, MM proportion being greater than 40% had a significant protection against NEC. We should encourage mother for breast milk and alert to NEC when the preterm is mixed feeding with MM proportion less than 40%.
Keywords
Very low birth weight (VLBW)/extremely low birth weight (ELBW), necrotizing enterocolitis (NEC), feeding intolerance (FI), maternal milk (MM) feeding.
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Xiaoyun Xiong
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 11 Dec, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: To examine the dose effect of maternal milk (MM) feeding on neonatal necrotizing enterocolitis (NEC) development.
Methods: This retrospective study included 305 infants [birth weight<1 500 g, or gestation age (GA)<32 weeks]. Curve estimation was performed to evaluate the dose relationship between MM proportion and NEC. Then infants were grouped based on curve trend and multivariable regression analysis was conducted to prove the curve estimation.
Results: Rate of NEC for the sample was 7.9% and age at onset was 25.6(16.0–26.0) days. The curve showed that when MM proportion was increased from zero to 20%, rate of NEC increased from 25% to 40% at first and when MM from 20% to 100%, rate dropped from 40% to near zero. In the MM proportion from zero to 40%, rate of NEC changed greatly. The multiple regression analysis showed that compared with MM proportion >0.70, 0.4<MM proportion £0.7 was associated with a 5.482- fold higher odds of developing NEC（P=0.032）; 0<MM proportion £0.4 was a 24.99-fold increase in the odds of developing NEC（P<0.001）; MM proportion =0 was a 9.348-fold increase in the odds of developing NEC（P=0.003）.
Conclusion: This study estimated how rate of NEC changed with MM proportion increase, MM proportion being greater than 40% had a significant protection against NEC. We should encourage mother for breast milk and alert to NEC when the preterm is mixed feeding with MM proportion less than 40%.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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