This preprint is under consideration at Journal of Nanobiotechnology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Ling Wen
Soochow University Affiliated No 1 People's Hospital: First Affiliated Hospital of Soochow University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1024-380X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue.
Results
Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%[email protected]4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer.
Conclusions
The rational designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.
Keywords
Rapid Liver Clearance, NIR-II region, Rare-earth core-shell nanoparticles, Dual-Modal imaging
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CURRENT STATUS: Under Revision
Version 1
Posted 12 Oct, 2021
No community comments so far
Review #3 received
Received 06 Oct, 2021
Editorial decision: Minor revision
On 06 Oct, 2021
Review #2 received
Received 26 Sep, 2021
Reviewer #3 agreed
On 25 Sep, 2021
Review #1 received
Received 22 Sep, 2021
Reviews received
Received 21 Sep, 2021
Reviewers invited
Invitations sent on 21 Sep, 2021
Reviewer #2 agreed
On 21 Sep, 2021
Editor invited
On 21 Sep, 2021
Editor assigned
On 20 Sep, 2021
Reviewer #1 agreed
On 20 Sep, 2021
Submission checks complete
On 20 Sep, 2021
First submitted
On 17 Sep, 2021
Metrics
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Subject Areas
Nanoscience
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This preprint is under consideration at Journal of Nanobiotechnology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Ling Wen
Soochow University Affiliated No 1 People's Hospital: First Affiliated Hospital of Soochow University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1024-380X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 12 Oct, 2021
No community comments so far
Review #3 received
Received 06 Oct, 2021
Editorial decision: Minor revision
On 06 Oct, 2021
Review #2 received
Received 26 Sep, 2021
Reviewer #3 agreed
On 25 Sep, 2021
Review #1 received
Received 22 Sep, 2021
Reviews received
Received 21 Sep, 2021
Reviewers invited
Invitations sent on 21 Sep, 2021
Reviewer #2 agreed
On 21 Sep, 2021
Editor invited
On 21 Sep, 2021
Editor assigned
On 20 Sep, 2021
Reviewer #1 agreed
On 20 Sep, 2021
Submission checks complete
On 20 Sep, 2021
First submitted
On 17 Sep, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nanoscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue.
Results
Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%[email protected]4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer.
Conclusions
The rational designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
This is a list of supplementary files associated with this preprint. Click to download.
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