In this study, we demonstrated the characteristics of all the confirmed cases from the fever outpatient clinic at SEH. First, the positive rate of COVID-19 at SEH was quite low, with a whole positive rate of 0.24%. The highest was in March 2020, which was only 1.09%. Furthermore, none of the confirmed patients who visited the fever outpatient clinic at the south campus of SEH were local residents. Additionally, no infections were reported among the medical staff, whether at SEH or in Shanghai [9]. These data indicated that the prevention and control measures at SEH were quite effective. The characteristics of all the confirmed COVID-19 cases at SEH, such as age, occupation, and region, varied at different phases of the epidemic. These data potentially reflected the prevention and control pressure at SEH shifting from domestic to imported cases as well as the real-time epidemic situation in SEH. In January and February 2020, the COVID-19 epidemic was mainly contained within the Chinese mainland. Patients with fever who visited the SEH south campus between January and February 2020 were mainly domestic, and four of the five confirmed cases were from Wuhan. In March 2020, with the lockdown being imposed in Wuhan for the control of the epidemic in China, the number of confirmed cases decreased significantly in mainland China. However, the epidemic had spread to Europe and other parts of the world, and large numbers of Chinese citizens who lived abroad returned home, which placed new pressure on China. This group of citizens comprised mainly of students who were studying abroad. Our data indicated that among the cases identified in March and April 23, 2020 had returned from abroad: 10 of the 11 from the UK were Chinese citizens studying in that country. Since May 2020, with the achievement of control over the epidemic in China, the SEH south campus fever clinic has mostly screened employees and students returning to their respective workplaces and schools. The sporadic two confirmed case identified at the clinic from May to September 2020 reveals the current, generally normal situation in China. As one of the largest general tertiary care hospitals in Pudong New District, SEH has made its contribution to COVID-19 prevention and control in Shanghai. On the other hand, the measures adopted by SEH were in response to national policies, which were confirmed to be quite successful [9]. Currently, the Shanghai customs office classifies people returning to Shanghai from abroad based on their region of origin. People returning from high-risk countries and regions are targeted for nucleic-acid testing when passing through Shanghai customs. If the nucleic-acid test is negative, they are quarantined for medical observation for a period of 14 days at a designated place. If the nucleic-acid test is positive, the medical administration arrange for an ambulance to transport the patient to our hospital with a closed-loop management system. The patient is isolated immediately after arriving at our hospital fever clinic. In addition to CT scan, medical history is taken, and nucleic acid and blood sample testing, expert consultation, and preliminary treatment are all performed in the isolation room. The samples are sent to the Center for Disease Control, where, if the nucleic acid tests positive again, the patient is transferred to the Shanghai Public Health Center for further treatment. During quarantine, their body temperature is monitored daily. People who show symptoms such as a fever or cough, are sent to nearby fever outpatient clinics for COVID-19 screening in a timely manner [10], and confirmed cases are transferred to the Shanghai Public Health Clinical Center for further treatment. Regarding the prevention and control of COVID-19, we have implemented strict measures to identify the source of infection among people entering Shanghai, cut off the route of transmission, and protected susceptible populations. The symptoms of the 29 confirmed patients reported in this study are consistent with the symptoms reported in the extant literature [11,12]. The main symptoms included fever, cough, pharyngalgia, and headache. Furthermore, laboratory tests revealed normal WBC counts and lymphopenia. Lung CT scans indicated that more than half of the patients had remarkable lung CT imaging findings. According to the new coronavirus pneumonia diagnosis and treatment program implemented by the National Health Commission, the lung CT scans of COVID-19-positive patients indicated ground-glass opacity findings, which are typical changes observed in viral pneumonia [13]. The diagnosis of COVID-19 mainly relies on the etiology of the disease and the results of coronavirus RT-PCR testing, and patients with positive results are considered to have confirmed cases. Specific treatment and prevention options for COVID-19, such as targeted antiviral drugs, nucleoside analogs, chloroquine, protease inhibitors, and vaccines, were not available because of the lack of clinical evidence during the timeframe in which the study was conducted [14]. Instead, clinicians in China focused on traditional public health outbreak response tactics such as isolation, quarantine, social distancing, and community containment. Patients with mild illness and normal pneumonia were mainly treated with supportive care. On May 1, 2020, the China Food and Drug Administration granted emergency access to remdesivir, a nucleotide analog prodrug that inhibits viral RNA polymerases, for patients and children with severe COVID-19. However, the use of remdesivir to treat COVID-19 remains controversial [15-17]. To date, there is no evidence for the role of traditional Chinese medicines and other antiviral drugs in the treatment of COVID-19. Corticosteroids for COVID-19 treatment are neither recommended by the WHO nor by the China National Health Commission [18]. Based on the characteristics of the confirmed cases at SEH and the clinical evidence and availability of drugs, supportive care is the main treatment for patients at the SEH fever clinic. This study had some limitations. First, more detailed patient information, particularly regarding the clinical outcomes, was unavailable at the time of analysis, and therefore, this is not included in this study. Second, the data of confirmed COVID-19 cases at SEH alone are presented. A larger sample size is required to be more representative of the population of Shanghai. Third, the confirmed cases were transferred to the Shanghai Public Health Clinical Center, which collected limited treatment data.