In our earlier work [ 1 , ] a correlation was established between Infection fatality rate ( IFR ) vs age of the patient by logistic or sigmoid regression model . The regression model shows a more probable IFR with a sigmoid rise after 46 yrs and becoming most significant after 70 yrs and above. In the present study the frequency of infected patient by ‘ G ‘ type of mutants of SARS-COV-2 with time from Jan, 2020 to June, 2020 for 6.5 months duration of experimental study. The best fit analysis is compared to Morgan – Morgan – Finney ( MMF ) model ( 3,4 ) statistics and Polynomial regression model. Both the above model correlates a significant result with Pearson coefficient ( r ), Probability ( p-value ). The RBD of D614G( 10 ) interaction with Angiotensin Converting Enzyme-II ( ACE2) of host cell can be also correlated to another new spike mutant like N501Y ( 11) through Pearson coefficient ( r ) with p-value of significance.