Cohort Profile: The Nigerian HIV Geriatric Cohort Study

doi:10.21203/rs.2.18662/v3

Download PDF

Research article

Cohort Profile: The Nigerian HIV Geriatric Cohort Study

https://doi.org/10.21203/rs.2.18662/v3

This work is licensed under a CC BY 4.0 License

Journal Publication

published 26 Nov, 2020

Read the published version in BMC Public Health →

You are reading this older preprint version

Read the latest preprint version →

Background: The Nigerian HIV Geriatric Cohort (NHGC) is a longitudinal cohort setup to learn how elderly people living with HIV (EPLHIV) in Nigeria fare, despite not being prioritized by the national treatment program, and to deepen knowledge for their differentiated care and achieve better outcomes. In this paper, we describe data collected on sociodemographic and clinical data from EPLHIV from the inception of Nigeria’s national HIV program to 2018.

Methods: Patient-level data spanning the period 2004 to 2018, obtained from comprehensive HIV treatment hospitals, that are supported by four major PEPFAR-implementing partners in Nigeria were used. These 4 entities collaborated as member organizations of the Nigeria Implementation Science Alliance. We defined elderly as those aged 50 years and above. From deidentified treatment records, demographic and clinical data of EPLHIV ≥50-year-old at ART initiation during the review period was extracted, merged into a single REDcap® database, and described using STATA 13.

Results: A total of 101,652 unique EPLHIV entries were analysed. This cohort’s data was of 53,608(52.7%) women, 51,037(71.4%) of EPLHIV identified as married and 33,446(51.1%) unemployed. Mean age was 57.1 years (SD=6.9) with average duration on ART as 4.6 years (SD=3.5). ART profile showed that 88,792(95.7%) were on 1st-line and 55,905 (64.9%) were on TDF-based regimens. Mean-body mass index (BMI) was 23.0 kg/m² (SD=5.4 kg/m²) with 56,010(55.1%), 19,619(19.3%) and 8844(8.7%) showing normal (18.5kg/m²–24.9kg/m²), overweight (BMI 25 -<30kg/m²) and obese (BMI ≥30kg/m²) ranges respectively. Prevalence of hypertension (systolic-BP >140mmHg or diastolic-BP >90mmHg) was 21,550(21.2%). EPLHIV Mean CD4 count was 420cells/μL (SD=285cells/μL) and 83,660(82.3%) had a viral load result showing <1000copies/ml. As for treatment outcomes, available records showed that 54.1% were active-in-treatment, 28.4% were lost-to-follow-up and 6.8% died. Poor population death records and aversion to autopsies makes it almost impossible to estimate AIDS-related deaths.

Conclusions: This cohort describes the clinical and non-clinical profile of EPLHIV in Nigeria. We are following up the cohort to design and implement intervention programs, develop prognostic models to achieve better care outcomes for EPLHIV. This cohort would provide vital information for stakeholders in HIV prevention, care and treatment to understand the characteristics of EPLHIV.

Infectious Diseases

Geriatrics & Gerontology

Health Economics & Outcomes Research

Elderly

Geriatric

HIV/AIDS

Nigeria

Older adults living with the human immunodeficiency virus (HIV) are set to multiply worldwide [1–3]. HIV/AIDS is a major public health problem among older adults, appeoximately 6 million people over the age of 50 years are living with HIV worldwide.[4] In sub-Saharan Africa, approximately 3 million people older than 50 years of age, are HIV-infected, which represents an average of 14% of affected adults and 11% of adults on antiretroviral therapy (ART) [5,6]. In Nigeria, a cross-sectional study at one of the largest treatment centres, reported that 10% of the studied population were aged, 51 to 60 years, while 0.6% were >60 years [7]. At the national level, 54% of the 3.4 million people that were living with HIV in 2012 were between 15 to 64 years[8]. The recently concluded 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS), a household-based survey that assessed the prevalence of HIV and related health indicators in household members aged 0-64 years old, found the distribution of HIV burden across those aged 50 years and above at 13%, which is approximately 280,000 based on new total estimates of 1.9 million persons living with HIV in Nigeria[9]. Based on the NAIIS, gender disaggregation statistics showed that prevalence was highest among females aged 35-39 years at 3.3%, and the highest among males age 50-54 years at 2.3%. A cross-sectional study at a large treatment facility, reported that 10% of the studied population were aged 51 to 60 years, while 0.6% were >60 years[7]. This pool will grow significantly as many ART patients are expected to cross the 50-years baseline, given the efficacy of ART and the current global drive to expand access to treatment and end HIV/AIDS by 2030[10].

Information on the geriatric population living with HIV in Nigeria is sparse and a systematic description of the HIV geriatric cohort is required to change this. The early and widely recognized impact of AIDS on the elderly was the phenomenon of AIDS orphans— children who lost at least a parent as a result of HIV-related mortality. The report Children on the Brink: 2002 indicates that in 2001, there were 38 million orphans in Africa, 11 million of whom were attributable to AIDS mortality[11]. It predicted that in 2010, 42 million orphans will be in Africa, 20 million of whom will be the result of AIDS mortality. Since formal social security systems do not exist in most sub-Saharan African countries, the elderly largely bear the burden of taking care of the orphans, which compromises their health[12].

HIV-infection and attendant antiretroviral (ARV) treatment complicate elderly health. AIDS has a disproportionate impact on the health of the elderly compared with the younger adults[13]. Opportunistic infections (OIs) such as pneumocystis pneumonia, extra-pulmonary tuberculosis, and candidiasis have been reported in the elderly[13]. Both HIV and aging synergistically decrease function of B and T-cell lymphocytes which compromises the host’s immunity leading to more OIs. Also, HIV-infection independently creates metabolic abnormalities[14,15] and the toxicities of ARVs and certain drugs used for OIs, create a wide range of diseases including, type 2 diabetes mellitus, myocardial infarction (MI) and atherosclerotic cardiovascular disease[16,17]. In 2016, a Médecins Sans Frontières (MSF) multi-national study reported a higher risk of death among HIV infected people who were aged 50 years and above[16]. Furthermore, age is a risk factor for cardiometabolic disorders; thus, older adults are likely to bear a dual burden of HIV and cardio-metabolic abnormalities[18], which is on the rise in sub-Saharan Africa.

Nigeria’s HIV-infected elderly face significant challenges due to age, inadequate health care, low social security and a dwindling economy. Although this context necessitates a concerted focus on the elderly, there is no structured care for them. Several reasons contribute to this; earlier studies projected HIV/AIDS prevalence and transmission as a youth issue[2], this has inadvertently omitted elderly-care in the HIV-control program design. Being elderly is associated with sustaining risky behaviour like less condom use, higher preference for multiple sexual partners[19] and wife inheritance[20], which predisposes to new infections[21,22].

It is therefore critical to establish a HIV geriatric cohort in Nigeria to provide evidence to add life to years[23], improve quality of life and outcomes of older adults living with HIV. In this paper, we described data collected on sociodemographic and clinical data from older HIV positive clients from the inception of Nigeria’s national HIV program, and we plan to longitudinally study this cohort with the aim of designing and implementing intervention programs that would improve better health outcomes.

Which cohorts contribute to the collaboration?

The treatment and prevention of HIV/AIDS in Nigeria is coordinated by the National Agency for the Control of AIDS (NACA) – an agency of the Federal Ministry of Health (FMOH). The United States of America’s Government (USG) since 2006, through its Presidents Emergency Plan for AIDS Relief (PEPFAR), supported Nigeria’s free access ART program. Four major implementing partners (IPs) directly cover the treatment program across all of Nigeria’s six geopolitical regions in partnership with health facilities under the general supervision of the US agencies and NACA.

These IPs provide technical support for HIV treatment in most Nigerian states, they include: the Institute of Human Virology Nigeria (IHVN) covering the Federal Capital Territory (FCT) and 4 States (Kano, Katsina and Nassarawa); FHI360 covering 12 States (Adamawa, Akwa Ibom, Anambra, Bauchi, Bayelsa, Borno, Cross River, Edo, Jigawa, Lagos, Rivers and Yobe); APIN Public Health Initiative in Nigeria (APIN) covering 8 States (Lagos, Ogun, Osun, Ekiti, Ondo, Oyo, Plateau and Benue); and Catholic Caritas Foundation of Nigeria (CCFNG) covering 4 States (Delta, Ebonyi, Enugu and Imo). These IPs use a nationally standardized method of data collection and schedule monthly follow-up visits for their patients. This cohort is the first to be set-up to pool geriatric data from these IPs. Furthermore, to the best of our knowledge, no study has described Nigeria’s nationwide geriatric HIV positive population using combined data from these IPs. Definition of terms

Older age: The statistical cut-off for assessing old age varies. Rather than artificially categorizing life into stages such as middle age or old age, it assumes we age from birth. Nevertheless, for statistical purposes, it is often necessary to divide populations into age groups. The analyses the World Health Organization (WHO) uses generally applies 60 years and over as a statistical cut-off[23]. However, some analyses refer to populations of different ages such as ≥ 50 years, ≥ 65 years or ≥ 80 years. In this study, we adopted ≥50 years as our cut-off for old age. This assumption is based on Nigeria’s population life expectancy from birth (2016) which was 54 years [men (55years); women (56years)][24]. Participants who are ≥50 years at time of testing positive to HIV will be classified as ‘older adults’, ‘elderly’ or ‘geriatrics’.

WHO stage 3 and 4: The diseases defined as WHO stage 3 and 4 in this study are presented in Table 2.2 (pages 28 to 29) of the National Guidelines for HIV Prevention Treatment and Care (2016)[8].

Who is in the cohort?

The USG, through PEPFAR, funded the free access program through its agencies: the Centers for Disease Control and Prevention (CDC), United States Agency for International Development (USAID) and Department of Defense (DoD). IPs with affiliations to US institutions were recruited with the responsibility of treating and preventing HIV/AIDS under the direct supervision of these US agencies. The major IPs, which included IHVN, FHI360, APIN and CCFNG, work with health facilities selected from all of Nigeria’s six geopolitical regions, under which states are grouped, to provide treatment and laboratory services to PLHIV. These IPs manage a network of health facilities in the states assigned to them by NACA and the US agencies. Each IP maintains a treatment database generated from the health facilities under its purview.

Patient-level sociodemographic and clinical databases of all HIV-infected individuals treated at the health facilities supported by the IPs were used with the earliest entry recorded in 2004. In routine practice, patients are prospectively enrolled at first contact with a HIV-service facility and are followed-up bimonthly. In this longitudinal geriatrics cohort, we used de-identified data of HIV-infected people who are 50 years and above from the date first tested positive for HIV as contained in the IPs databases between the period 2004 – 2018. The databases were merged as a single REDcap® database and analysed using STATA13. Ethical clearance for the use of the secondary data was obtained from the IRB board (IRB019-SD) of APIN (see appendix 1).

What has been measured?

The variables collected at patient’s clinic visit are standardized across the IPs using the nationally standardized Case Report Forms (CRFs). Data was collected at baseline and scheduled follow-up visits on sociodemographic (sex, age, marital status, education, occupation), dates of HIV diagnosis and initiating therapy, AIDS-defining conditions, longitudinal laboratory data (CD4 cell count, viral load), ART regimen and others to determine HIV comorbidities (blood pressure, body mass index, blood glucose measurements). Trained clinicians obtained this information at each patient’s visit. The HIV biomarkers including CD4 cell count done 6-monthly and since 2016 routine viral load done 6 months post-initiation of ARTs for newly identified clients, then yearly for stable patients (VL<1000copies/ml) and more frequently as needed for patients with derailed values. The CRFs are entered into a secure electronic capture database with a study ID used as a unique patient identifier. Data was cleaned and stored in a central geriatric database. In this study, we report

baseline characteristics, treatment and clinical outcomes as percentages for categorical data and means (standard deviation) for continuous data.

What has been found?

Figure 1 shows that a total of 101 652 geriatrics [(IHVN=10 629 (10.5%); APIN=28 624 (28.2%); FHI360 =51 918 (51.1%); CCFNG = 10 481 (10.3%)] were enrolled for treatment at the health facilities supported by the IPs in 28 of the 36 States in Nigeria and the FCT. The NHGC includes approximately 36% of estimated EPLHIV in Nigeria, mean age was 57.1 (SD= 6.9); majority were women (52.7%) and married (71.4%). The cohort’s socio-demographic findings are presented in Table 1: participants data showed secondary school education attendance by at least 50.4% and unemployment in about 51.1%.

Figure 1

TABLE 1

Table 2 and Table 3 present the clinical and treatment characteristics respectively: most of the participants (72.2%) commenced ART at WHO stage I/II; mean duration of therapy was 5.1 years (SD=3.3 years); majority were on 1st line regimen (99.1%) – the TDF based regimen had the highest number of patients (54.8%), consistent with the requirement of the treatment guidelines. Cohort’s Mean (SD) body mass index (BMI) at enrolment was 23.0 kg/m². 55.1 % had normal BMI (18.5kg/m² – 24.9kg/m²), but 19.3% were overweight with a BMI of 25-<30kg/m² and a few were obese (8.7%) with a BMI of ≥30kg/m². Mean systolic and diastolic blood measurements were 122.4 (SD=24.8) mmHg and 78.1 (SD=14.8) mmHg respectively; 21.2% of patients had hypertensive readings (systolic blood pressure >140mmHg or diastolic blood pressure >90mmHg). Mean CD4 count was 420 cells/μL (SD=285 cells/μL) and most patients (82.3%) had viral suppression less than 1,000 copies/ml. In terms of treatment outcomes, 54.1% were active in treatment; 28.4% lost to follow-up and 6.8% died, while on treatment.

TABLE 2

TABLE 3

Main findings

This study described the characteristics of EPLHIV in Nigeria; we found a lower prevalence of hypertension in older people on ART in Nigeria as compared to the prevalence of hypertension in sub-Saharan Africa (31.9%; 95%CI 18.5% - 49.2%) and the global prevalence of hypertension (42.0%; 95%CI 29.0% – 55.4%)[25]. Despite the relatively low prevalence of hypertension in older people living with HIV in Nigeria, it is very important for public health experts to deploy preventive interventions that will reduce the occurrence of hypertension. Also, government, HIV program implementers, donors and other HIV stakeholders should ensure that older people on ART who are living with high blood pressure should be able to receive care for hypertension when they visit HIV clinic. In addition, we observed that four out of five older people commenced on ART, were achieving viral suppression which is commendable. This estimate is very similar to the national prevalence of viral suppression among the total number of people placed on ART in Nigeria[26]. Our finding is consistent with the regional prevalence of viral suppression among people on ART in West and Central Africa region[27] but lower than the observed prevalence in East and Southern Africa region[28]. However, despite the high prevalence of viral suppression among patients on ART in Nigeria, including most African countries, more effort should be geared towards improving HIV identification as less than two-thirds of this populations are aware of their HIV status[26].

Future plans

The NHGC is the largest cohort of EPLHIV in Nigeria; it provides a strong base for future studies on comorbidities associated with aging in EPLHIV in the country. We plan to follow up this cohort and obtain data that would be used to implement intervention programs, develop prognostic models and predict better outcomes for EPLHIV using multi-variable indices.

What are the main strengths and weaknesses?

A large pool of geriatric patients and the collaborating spirit of the IPs contributing data to this cohort is a key strength for the NHGC. The substantial dataset of the NGHC permits examination of prognoses in improving the quality of life of EPLHIV. Data of patients in this cohort are collected during routine clinical visits, and incomplete data from missing variables exist. Data on AIDS- mortality is likely under-reported as ART clients that died outside hospital settings may never have this status reverted to their service provider except following active tracking. Furthermore, public mortality repositories in Nigeria do not usually share information with hospitals and clinical autopsies are not mainstream[29,30].

Another expected limitation of a longitudinal cohort study is loss to follow-up, a particularly challenging norm in low income settings where participants have a poor history of follow-up in clinical care. To improve patient’s retention in our cohort, we developed a monitoring and tracking system to identify patients that are due for follow up visits. These patients are called using registered anonymous public health lines and sent cyphered short message service prompts to remind them of their clinic visits. We also deployed community engagement strategies and care group network to keep the patients engaged in care.

Can I get hold of the data? Where can I find out more?

The chief investigator of the study is Patrick Dakum, whose e-mail contact is ([email protected]). The data remains the property of the contributing NISA member organizations, whose representatives manage the NHGC via a steering committee of the collaboration. Inquiries on the use of collected data are welcomed and encouraged and all proposals for specific analyses are to be reviewed by a scientific committee.

The NHGC represents about 36% of the total estimates and is the largest cohort of EPLHIV in Nigeria. It provides a strong basis for studies on comorbidities associated with aging in EPLHIV in the country. Longitudinal monitoring of this cohort could be used to design and implement intervention programs, develop prognostic models and achieve better care outcomes for EPLHIV.

HIV: Human immunodeficiency virus; ART: Antiretroviral therapy; AIDS: Acquired immune deficiency syndrome; NAIIS: Nigeria HIV/AIDS indicator and impact survey; ARV: Antiretroviral, OIs: Opportunistic infections; IM: Myocardial infarction; MSF: Médecins Sans Frontières; NACA: National Agency for the Control of AIDS; FMOH: Federal Ministry of Health; USG: United States of America’s Government; PEPFAR: its Presidents Emergency Plan for AIDS Relief; IPs: Implementing partners; IHVN: Institute of Human Virology Nigeria; FCT: Federal Capital Territory; APIN: Public Health Initiative in Nigeria; CCFNG: Catholic Caritas Foundation of Nigeria; CDC: Centers for Disease Control and Prevention; USAID: United States Agency for International Development; DoD: Department of Defense; PLHIV: People living with HIV; CRFs: Case Report Forms, VL: Viral load; DTG: Dolutegravir; BMI: Body mass index; SD: Standard deviation, EPLHIV: Elderly people living with HIV; NHGC: Nigerian HIV Geriatric Cohort.

Acknowledgements

The NHGC is not possible without the ongoing contribution of all ART focal persons and clinic managers, pharmacists and staff at the diagnostic laboratories and facilities in the HIV treatment facilities. We also acknowledge the work of the data collecting and monitoring staff working with the collaborating IPs.

Authors’ contributions

PD conceived the idea and wrote the first draft, MO, JO and GK analysed the data. IN, ND, CM, HK, PO and EE with all all authors have read and approved the manuscript.

Funding

No funding was received to conduct this study

Availability of data and materials

The datasets are available from the corresponding author on reasonable request.

Ethics approval and consent to participate

Ethical clearance for the use of the secondary data was obtained from the IRB board (IRB019 SD) of AIDS Prevention Initiative in Nigeria APIN.

Consent for publication

Not applicable.

Competing interests

We declare no competing interests and state no conflicts of Interest.

Author details

¹Institute of Human Virology, Abuja, Nigeria. ²APIN Public Health Initiatives, Ltd/Gte, Abuja, Nigeria. ³FHI360, Abuja, Nigeria. ⁴Catholic Caritas Foundation of Nigeria, Abuja, Nigeria. ⁵Nigeria Implementation Science Alliance, Abuja, Nigeria. ⁶Department of Paediatrics and Child health, University of Nigeria, Enugu, Nigeria.

Manfredi R. HIV infection and advanced age emerging epidemiological, clinical, and management issues. Ageing Res Rev. 2004;3: 31–54. doi:10.1016/j.arr.2003.07.001
Inelman EM, Gasparini G, Enzi G. HIV/AIDS in older adults: a case report and literature review. Geriatrics. 2005;60: 26–30.
Albone R. Older people remain invisible in the response to HIV and AIDS. In: HelpAge International [Internet]. [cited 13 May 2020]. Available: https://www.helpage.org/blogs/rachel-albone-667/older-people-remain-invisible-in-the-response-to-hiv-and-aids-201/
Autenrieth CS, Beck EJ, Stelzle D, Mallouris C, Mahy M, Ghys P. Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020. PLoS ONE. 2018;13. doi:10.1371/journal.pone.0207005
Negin J, Cumming RG. HIV infection in older adults in sub-Saharan Africa: extrapolating prevalence from existing data. Bull World Health Organ. 2010;88: 847–853. doi:10.2471/BLT.10.076349
Negin J, Mills EJ, Bärnighausen T. Aging with HIV in Africa: the challenges of living longer. AIDS Lond Engl. 2012;26: S1–S5. doi:10.1097/QAD.0b013e3283560f54
Avong YK, van Wyk B, Njab J, Abimiku AG, Ndembi N, Okuma J, et al. Adherence to Anti-Retroviral Therapy in North Central Nigeria. Curr HIV Res. 2015;13: 268–278. doi:10.2174/1570162x13666150202094120
Federal Ministry of Health Nigeria. National Guidelines for HIV Prevention Treatment and Care, Abuja. Available: http://apps.who.int/medicinedocs/documents/s23252en/s23252en.pdf
National Agency for the Control of AIDS Nigeria. Revised National Hiv and Aids Strategic Framework. Nigeria; Available: https://naca.gov.ng/wp-content/uploads/2019/03/NATIONAL-HIV-AND-AIDS-STRATEGIC-FRAMEWORK-1.pdf
UNAIDS. 90-90-90 - An ambitious treatment target to help end the AIDS epidemic. Available: https://www.unaids.org/sites/default/files/media_asset/90-90-90_en_0.pdf
USAID. Children on the Brink 2002 : A Joint Report on Orphan Estimates and Program Strategies. Available: http://data.unaids.org/topics/young-people/childrenonthebrink_en.pdf
Lekalakala-Mokgele E. A literature review of the impact of HIV and AIDS on the role of the elderly in the sub-Saharan African community. Health SA Gesondheid Online. 2011;16: 1–6.
Hontelez JAC, de Vlas SJ, Baltussen R, Newell M-L, Bakker R, Tanser F, et al. The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa. AIDS Lond Engl. 2012;26 Suppl 1: S19-30. doi:10.1097/QAD.0b013e3283558526
Hommes MJ, Romijn JA, Endert E, Eeftinck Schattenkerk JK, Sauerwein HP. Insulin sensitivity and insulin clearance in human immunodeficiency virus-infected men. Metabolism. 1991;40: 651–656. doi:10.1016/0026-0495(91)90059-6
Hadigan C, Miller K, Corcoran C, Anderson E, Basgoz N, Grinspoon S. Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1999;84: 1932–1937. doi:10.1210/jcem.84.6.5738
Behrens G, Dejam A, Schmidt H, Balks HJ, Brabant G, Körner T, et al. Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors. AIDS Lond Engl. 1999;13: F63-70. doi:10.1097/00002030-199907090-00001
Brown TT, Cole SR, Li X, Kingsley LA, Palella FJ, Riddler SA, et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med. 2005;165: 1179–1184. doi:10.1001/archinte.165.10.1179
Gebo KA, Justice A. HIV infection in the elderly. Curr Infect Dis Rep. 2009;11: 246–254. doi:10.1007/s11908-009-0036-0
Sefasi AP. Impact of HIV and AIDS on the eldery: A case study of Chiladzulu district. Malawi Med J J Med Assoc Malawi. 2010;22: 101–103.
Buckley S. AIDS in Kenya:Wife Inheritance Spurs AIDS Rise in Kenya. [cited 13 May 2020]. Available: https://www.washingtonpost.com/wp-srv/inatl/longterm/africanlives/kenya/kenya_aids.htm
Williams A, Tumwekwase G. We will be alone when we die: HIV/AIDS and the aged in Rural Uganda. 1999.
United Nations Department of Economic and Social Affairs/Population Division. The Impact of AIDS. New York, United States; Available: https://www.un.org/en/development/desa/population/publications/hiv-aids/aids-impact.asp
WHO. Good health adds life to years. In: WHO [Internet]. World Health Organization; [cited 13 May 2020]. Available: http://www.who.int/ageing/publications/whd2012_global_brief/en/
WHO. Nigeria: Country profile. In: WHO [Internet]. World Health Organization; [cited 13 May 2020]. Available: http://www.who.int/countries/nga/en/
Dakum P, Kayode GA, Abimiku A, Avong YK, Okuma J, Onyemata E, et al. Prevalence of hypertension among patients aged 50 and older living with human immunodeficiency virus. Medicine (Baltimore). 2019;98. doi:10.1097/MD.0000000000015024
HIV and AIDS in Nigeria. [cited 13 May 2020]. Available: https://www.avert.org/professionals/hiv-around-world/sub-saharan-africa/nigeria
HIV and AIDS in West and Central Africa. [cited 13 May 2020]. Available: https://www.avert.org/hiv-and-aids-west-and-central-africa
HIV and AIDS in East and Southern Africa Regional Overview. [cited 13 May 2020]. Available: https://www.avert.org/professionals/hiv-around-world/sub-saharan-africa/overview
Oluwasola OA, Fawole OI, Otegbayo AJ, Ogun GO, Adebamowo CA, Bamigboye AE. The autopsy: knowledge, attitude, and perceptions of doctors and relatives of the deceased. Arch Pathol Lab Med. 2009;133: 78–82. doi:10.1043/1543-2165-133.1.78
Oluwasola AO, Fawole OI, Otegbayo JA, Ayede IA, Ogun GO, Ukah CO, et al. Trends in clinical autopsy rate in a Nigerian tertiary hospital. Afr J Med Med Sci. 2007;36: 267–272.

*Table 1 Characteristics of Nigeria HIV Geriatrics Study Population (N=101 652)*
Characteristics	GERIATICS (50+ years) means ± SD or %
Gender, Females	53 608 (52.7%)
Age, years	57.1 ± 6.9
Age categories
50 -<60	72 894 (71.7%)
60 -<70	22 740 (22.4%)
70+	6018 (5.9%)
Marital Status
Single	3493 (6.0%)
Married	51 037 (71.4%)
Widowed	12 577 (17.6%)
Separated	24 35 (3.4%)
Divorced	1932 (2.7%)
Education
None	11 657 (18.8%)
Quranic	1290 (2.1%)
Primary	17 842 (28.8%)
Secondary	19 768 (31.8%)
Post-Secondary	11 512 (18.6%)
Occupation
Unemployed	33 446 (51.1%)
Student	196 (0.3%)
Employed	29 977 (45.8%)
Retired	1832 (2.8%)
Service Entry Point
HCT	14 920 (62.5%)
Outpatient department	5227 (21.9%)
Transfer In	1671 (7.0%)
In-patient	692 (2.9%)
Outreaches	310 (1.3%)
Others	1027 (4.3%)
Provider/Implementing Partner
APIN	28 624 (28.2%)
CCFNG	10 481 (10.3%)
FHI360	51 918 (51.1%)
IHVN	10 629 (10.5%)

*Table 2 Baseline Clinical characteristics of Nigeria HIV Geriatrics Study Population (N=101 652)*
Clinical Characteristics	Geriatrics (50+ years) (N=101 652) means ± SD or %
WHO Stage
I	26 617 (46.7%)
II	14 500 (25.5%)
III	13 728 (24.1%)
IV	2102 (3.7%)
Weight, kg	60.6 ± 13.8
BP Systolic (SBP), mmHg	122.4 ± 24.8
BP Diastolic (DBP), mmHg	78.1 ± 14.8
Hypertension
(SBP>140 or DBP>90 mmHg)	3407 (21.2%)
BMI, kg/m²	23.0 ± 5.4
BMI Categories, kg/m²
<17	1881 (8.0%)
17-<18.5	2101 (8.9%)
18.5-<25	12 967 (55.1%)
25-<30	4548 (19.3%)
30+	2051 (8.7%)
CD4 Cell Count, cells/μl	420 ± 285
CD4 cell count <200, cells/μl	8268 (23.2%)
CD4 cell count <500, cells/μl	23 623 (82.3%)

*Table 3 Treatment Characteristics of Nigeria HIV Geriatrics Study Population (N=101652)*
Treatment Characteristics	Geriatics (50+ years) means ± SD or %
Current ART Line
First Line	88 792 (95.7%)
Second Line	3999 (4.3%)
Current ART Regimen
ABC-Based	227 (0.3%)
AZT-Based	27 150 (31.5%)
TDF-Based	55 905 (64.9%)
Others	2868 (3.3%)
Years on ART Treatment	4.6 ± 3.5
Years on ART Treatment
<2 years	13 406 (28.8%)
2 – 5 years	14 262 (30.6%)
5 – 10 years	14 457 (31.0%)
10+ years	4503 (9.7%)
Viral Suppression (VL <1000 copies/ml)	26 687 (82.3) %
Current ART Status
Active	37 030 (54.1%)
Active -transfer in	1978 (3.8%)
Dead	4220 (6.8%)
In Active	2630 (3.9%)
Lost to follow-up	19 445 (28.4%)
Stopped	1062 (1.6%)

Values are means ± SD or percentages.

Download PDF

Journal Publication

published 26 Nov, 2020

Read the published version in BMC Public Health →

Editorial decision: Major revision
20 Aug, 2020
Review #1 received at journal
11 Aug, 2020
Reviewers invited by journal
03 Aug, 2020
Reviewer #1 agreed at journal
03 Aug, 2020
Editor assigned by journal
31 Jul, 2020
Submission checks completed at journal
30 Jul, 2020
Editor invited by journal
30 Jul, 2020

You are reading this older preprint version

Read the latest preprint version →

Cohort Profile: The Nigerian HIV Geriatric Cohort Study

Status:

Journal Publication

Version 3

Abstract

Figures

Background

Methods

Results

Discussions

Conclusion

Abbreviations

Declarations

References

Tables

Status:

Journal Publication

Version 3