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Research article
Changzheng Chen
Wuhan University Renmin Hospital
Corresponding Author
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Background: To quantify blood flow changes in choriocapillaris (CC) of chronic central serous chorioretinopathy (CCSC) patients receiving half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA).
Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA.
Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up when compared with that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.
Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.
Keywords
Chronic, Central Serous Chorioretinopathy, Optical Coherence Tomography Angiography, Photodynamic Therapy
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CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
No community comments so far
Submission checks complete
On 01 Oct, 2020
Editorial decision: Accept
On 30 Sep, 2020
Editor assigned
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 25 Sep, 2020
Editor assigned
On 22 Sep, 2020
Submission checks complete
On 21 Sep, 2020
Editor invited
On 21 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 18 Sep, 2020
Reviewer #1 agreed
On 15 Sep, 2020
Review #1 received
Received 15 Sep, 2020
Reviewers invited
Invitations sent on 09 Sep, 2020
Editor assigned
On 07 Sep, 2020
Submission checks complete
On 06 Sep, 2020
Editor invited
On 06 Sep, 2020
Version 3
Posted 21 Aug, 2020
No comments provided
Editorial decision: Major revision
On 02 Sep, 2020
Editor assigned
On 20 Aug, 2020
Submission checks complete
On 19 Aug, 2020
Editor invited
On 19 Aug, 2020
No comments provided
Editorial decision: Major revision
On 06 Aug, 2020
Review #4 received
Received 26 Jul, 2020
Reviewer #4 agreed
On 21 Jul, 2020
Review #3 received
Received 13 Jul, 2020
Reviewer #3 agreed
On 22 May, 2020
Review #2 received
Received 13 Apr, 2020
Reviewer #2 agreed
On 28 Mar, 2020
Review #1 received
Received 27 Feb, 2020
Reviewer #1 agreed
On 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Editor assigned
On 20 Jan, 2020
Editor invited
On 19 Jan, 2020
Submission checks complete
On 15 Jan, 2020
No comments provided
Review #2 received
Received 08 Jan, 2020
Editorial decision: Major revision
On 08 Jan, 2020
Review #1 received
Received 02 Jan, 2020
Reviewer #2 agreed
On 24 Dec, 2019
Reviewer #1 agreed
On 23 Dec, 2019
Editor assigned
On 23 Dec, 2019
Reviewers invited
Invitations sent on 23 Dec, 2019
Submission checks complete
On 11 Dec, 2019
Editor invited
On 09 Dec, 2019
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Subject Areas
Ophthalmology
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Ophthalmology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Changzheng Chen
Wuhan University Renmin Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
No community comments so far
Submission checks complete
On 01 Oct, 2020
Editorial decision: Accept
On 30 Sep, 2020
Editor assigned
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 25 Sep, 2020
Editor assigned
On 22 Sep, 2020
Submission checks complete
On 21 Sep, 2020
Editor invited
On 21 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 18 Sep, 2020
Reviewer #1 agreed
On 15 Sep, 2020
Review #1 received
Received 15 Sep, 2020
Reviewers invited
Invitations sent on 09 Sep, 2020
Editor assigned
On 07 Sep, 2020
Submission checks complete
On 06 Sep, 2020
Editor invited
On 06 Sep, 2020
Version 3
Posted 21 Aug, 2020
No comments provided
Editorial decision: Major revision
On 02 Sep, 2020
Editor assigned
On 20 Aug, 2020
Submission checks complete
On 19 Aug, 2020
Editor invited
On 19 Aug, 2020
No comments provided
Editorial decision: Major revision
On 06 Aug, 2020
Review #4 received
Received 26 Jul, 2020
Reviewer #4 agreed
On 21 Jul, 2020
Review #3 received
Received 13 Jul, 2020
Reviewer #3 agreed
On 22 May, 2020
Review #2 received
Received 13 Apr, 2020
Reviewer #2 agreed
On 28 Mar, 2020
Review #1 received
Received 27 Feb, 2020
Reviewer #1 agreed
On 24 Feb, 2020
Reviewers invited
Invitations sent on 20 Feb, 2020
Editor assigned
On 20 Jan, 2020
Editor invited
On 19 Jan, 2020
Submission checks complete
On 15 Jan, 2020
No comments provided
Review #2 received
Received 08 Jan, 2020
Editorial decision: Major revision
On 08 Jan, 2020
Review #1 received
Received 02 Jan, 2020
Reviewer #2 agreed
On 24 Dec, 2019
Reviewer #1 agreed
On 23 Dec, 2019
Editor assigned
On 23 Dec, 2019
Reviewers invited
Invitations sent on 23 Dec, 2019
Submission checks complete
On 11 Dec, 2019
Editor invited
On 09 Dec, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Ophthalmology.
Background: To quantify blood flow changes in choriocapillaris (CC) of chronic central serous chorioretinopathy (CCSC) patients receiving half-dose photodynamic therapy (PDT) using optical coherence tomography angiography (OCTA).
Methods: A total of 28 affected eyes and 24 unaffected eyes of 26 CCSC patients receiving half-dose PDT, and 40 eyes of 20 healthy gender- and age-matched subjects were retrospectively enrolled. The proportion of total areas of flow signal voids (FSV, %) in CC level of OCTA was assessed in both eyes of the CCSC patients at baseline and repeated in multiple sections at 1-week, 1-month, 3-month and 6-month intervals after PDT. In addition, CC patterns in response to PDT at early stage and their subsequent morphologic changes were qualitatively documented using OCTA.
Results: For affected eyes, significant decrease in FSV was found at 6-m follow-up when compared with that at 1-m follow-up (p=0.036). When compared to normal control eyes, FSV in affected eyes was significantly higher at 1-m, 3-m and 6-m follow-up (p<0.05 for all), while FSV in unaffected eyes was significantly higher at baseline, 1-w, 1-m and 3-m follow-up (p<0.05 for all). Three CC patterns of early response to PDT were identified, including signs of recovery with more even flow signals, transient appearance of worse ischemia and secondary neovascularization within CC level.
Conclusion: Abnormal CC flow attenuation remains in completely resolved eyes of CCSC patients treated with half-dose PDT.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
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