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Background and Objective: The morbidity and mortality of breast cancer are increasing in recent years, which had become the second main cause of cancer death in women. However, there are different characteristics of breast cancer in developing countries and developed countries. What’s more, it has not reported the comparison of breast cancer between southern China and the United States. We intend to compare the age, different stages and grades of tumor and treatment methods, in order to study the factors which influence the survival and prognosis of breast cancer patients.
Methods: To study the two groups which have been diagnosed with breast cancer in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. To follow up the patients who have been diagnosed before 2016. Kaplan-Meier method was used to evaluate disease-free survival (DFS) and overall survival (OS).
Results: Young breast cancer patients accounted for 19.8% and 6.14% respectively in southern China and SEER cohort. The early diagnostic rate of breast cancer is high in southern China, but still lower than SEER cohort. Our study found that there are significant differences in tumor size and positive lymph node status between southern China and SEER cohort (P=0.000), which notably affect the OS of breast cancer patients (P=0.018 and P=0.000). Furthermore, KI-67 is also an important prognostic factor of breast cancer patients in southern China, which also affect the OS of patients (P=0.034). In treatment, there are also significant differences between the two regions. In southern China, there are 4.91% of breast cancer patients performed breast conserving surgery and 95.09% patients performed mastectomy. But in SEER cohort, there are only 4.91% patients preformed breast surgery.
Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of breast cancer patients in southern China and SEER cohort. Overall, the prognosis of breast cancer patients in SEER cohort is better than southern China.
Keywords
Breast cancer, tumor pathology, Southern China, SEER database, survival
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This is a list of supplementary files associated with this preprint. Click to download.
- Supplementaryfigure1.tiff
Supplementary figure1: comparison DFS and OS in Southern China under different basic features. (A-B) Kaplan-Meier estimates DFS and OS of all patients in Southern China, (C-D) Kaplan-Meier estimates DFS and OS of different tumour size in Southern China, (E-F) Kaplan-Meier estimates DFS and OS of different nodal stage in Southern China, (G-H) Kaplan-Meier estimates DFS and OS of different ER stage in Southern China; (I-J) Kaplan-Meier estimates DFS and OS of different PR stage in Southern China, (K-L) Kaplan-Meier estimates DFS and OS of different HER2 stage in Southern China, (M-N) Kaplan-Meier estimates DFS and OS of different KI-67 expresssion in Southern China; (O-P) Kaplan-Meier estimates DFS and OS of surgery treatment in Southern China; (Q-R) Kaplan-Meier estimates DFS and OS of radiation in Southern China
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
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Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
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Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 23 Oct, 2020
No community comments so far
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Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background and Objective: The morbidity and mortality of breast cancer are increasing in recent years, which had become the second main cause of cancer death in women. However, there are different characteristics of breast cancer in developing countries and developed countries. What’s more, it has not reported the comparison of breast cancer between southern China and the United States. We intend to compare the age, different stages and grades of tumor and treatment methods, in order to study the factors which influence the survival and prognosis of breast cancer patients.
Methods: To study the two groups which have been diagnosed with breast cancer in southern China from 2001 to 2016 and SEER database from 1975 to 2016. To register, collect and analyze the clinicopathological features and treatment information. To follow up the patients who have been diagnosed before 2016. Kaplan-Meier method was used to evaluate disease-free survival (DFS) and overall survival (OS).
Results: Young breast cancer patients accounted for 19.8% and 6.14% respectively in southern China and SEER cohort. The early diagnostic rate of breast cancer is high in southern China, but still lower than SEER cohort. Our study found that there are significant differences in tumor size and positive lymph node status between southern China and SEER cohort (P=0.000), which notably affect the OS of breast cancer patients (P=0.018 and P=0.000). Furthermore, KI-67 is also an important prognostic factor of breast cancer patients in southern China, which also affect the OS of patients (P=0.034). In treatment, there are also significant differences between the two regions. In southern China, there are 4.91% of breast cancer patients performed breast conserving surgery and 95.09% patients performed mastectomy. But in SEER cohort, there are only 4.91% patients preformed breast surgery.
Conclusions: The age, tumor size, positive-node and KI-67 may cause the difference of morbidity and mortality of breast cancer patients in southern China and SEER cohort. Overall, the prognosis of breast cancer patients in SEER cohort is better than southern China.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
This is a list of supplementary files associated with this preprint. Click to download.
- Supplementaryfigure1.tiff
Supplementary figure1: comparison DFS and OS in Southern China under different basic features. (A-B) Kaplan-Meier estimates DFS and OS of all patients in Southern China, (C-D) Kaplan-Meier estimates DFS and OS of different tumour size in Southern China, (E-F) Kaplan-Meier estimates DFS and OS of different nodal stage in Southern China, (G-H) Kaplan-Meier estimates DFS and OS of different ER stage in Southern China; (I-J) Kaplan-Meier estimates DFS and OS of different PR stage in Southern China, (K-L) Kaplan-Meier estimates DFS and OS of different HER2 stage in Southern China, (M-N) Kaplan-Meier estimates DFS and OS of different KI-67 expresssion in Southern China; (O-P) Kaplan-Meier estimates DFS and OS of surgery treatment in Southern China; (Q-R) Kaplan-Meier estimates DFS and OS of radiation in Southern China
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