1. Papile L-A, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. The Journal of pediatrics. 1978;92(4):529-34.
2. Morales DM, Silver SA, Morgan CD, Mercer D, Inder TE, Holtzman DM, et al. Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein alpha, and L1 Cell Adhesion Molecule. Neurosurgery. 2017;80(1):82-90.
3. Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R, Network NR. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008;121(5):e1167-77.
4. Robinson S. Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts: a review. Journal of Neurosurgery: Pediatrics. 2012;9(3):242-58.
5. Bolisetty S, Dhawan A, Abdel-Latif M, Bajuk B, Stack J, Oei J-L, et al. Intraventricular hemorrhage and neurodevelopmental outcomes in extreme preterm infants. Pediatrics. 2014;133(1):55-62.
6. Mahaney KB, Buddhala C, Paturu M, Morales D, Limbrick Jr DD, Strahle JM. Intraventricular Hemorrhage Clearance in Human Neonatal Cerebrospinal Fluid: Associations With Hydrocephalus. Stroke. 2020;51(6):1712-9.
7. Limbrick DD, Morales DM, Shannon CN, Wellons JC, Kulkarni AV, Alvey JS, et al. Cerebrospinal fluid NCAM-1 concentration is associated with neurodevelopmental outcome in post-hemorrhagic hydrocephalus of prematurity. Plos one. 2021;16(3):e0247749.
8. Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, et al. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nature Reviews Neurology. 2020;16(5):285-96.
9. Flores JJ, Klebe D, Tang J, Zhang JH. A comprehensive review of therapeutic targets that induce microglia/macrophage‐mediated hematoma resolution after germinal matrix hemorrhage. Journal of neuroscience research. 2020;98(1):121-8.
10. Castaneyra-Ruiz L, Morales DM, McAllister JP, Brody SL, Isaacs AM, Strahle JM, et al. Blood exposure causes ventricular zone disruption and glial activation in vitro. Journal of Neuropathology & Experimental Neurology. 2018;77(9):803-13.
11. McAllister JP, Guerra MM, Ruiz LC, Jimenez AJ, Dominguez-Pinos D, Sival D, et al. Ventricular zone disruption in human neonates with intraventricular hemorrhage. Journal of Neuropathology & Experimental Neurology. 2017;76(5):358-75.
12. Park R, Moon UY, Park JY, Hughes LJ, Johnson RL, Cho S-H, et al. Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nature communications. 2016;7(1):1-14.
13. Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, et al. LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction. Science advances. 2019;5(10):eaax2011.
14. Isaacs AM, Smyser CD, Lean RE, Alexopoulos D, Han RH, Neil JJ, et al. MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity. NeuroImage: Clinical. 2019;24:102031.
15. Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, et al. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature medicine. 2017;23(8):997.
16. Limbrick Jr DD, Castaneyra-Ruiz L, Han RH, Berger D, McAllister JP, Morales DM. Cerebrospinal fluid biomarkers of pediatric hydrocephalus. Pediatric neurosurgery. 2017;52(6):426-35.
17. Castañeyra-Ruiz L, Hernández-Abad LG, Carmona-Calero EM, Castañeyra-Perdomo A, González-Marrero I. AQP1 overexpression in the CSF of obstructive hydrocephalus and inversion of its polarity in the choroid plexus of a chiari malformation type II case. Journal of Neuropathology & Experimental Neurology. 2019;78(7):641-7.
18. Habiyaremye G, Morales DM, Morgan CD, McAllister JP, CreveCoeur TS, Han RH, et al. Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus. Fluids and Barriers of the CNS. 2017;14(1):1-10.
19. Chow LC, Soliman A, Zandian M, Danielpour M, Krueger Jr RC. Accumulation of transforming growth factor-β2 and nitrated chondroitin sulfate proteoglycans in cerebrospinal fluid correlates with poor neurologic outcome in preterm hydrocephalus. Neonatology. 2005;88(1):1-11.
20. Heep A, Stoffel-Wagner B, Bartmann P, Benseler S, Schaller C, Groneck P, et al. Vascular endothelial growth factor and transforming growth factor-β1 are highly expressed in the cerebrospinal fluid of premature infants with posthemorrhagic hydrocephalus. Pediatric research. 2004;56(5):768-74.
21. Kitazawa K, Tada T. Elevation of transforming growth factor-beta 1 level in cerebrospinal fluid of patients with communicating hydrocephalus after subarachnoid hemorrhage. Stroke. 1994;25(7):1400-4.
22. Whitelaw A, Christie S, Pople I. Transforming growth factor-β1: a possible signal molecule for posthemorrhagic hydrocephalus? Pediatric research. 1999;46(5):576-.
23. Heep A, Bartmann P, Stoffel-Wagner B, Bos A, Hoving E, Brouwer O, et al. Cerebrospinal fluid obstruction and malabsorption in human neonatal hydrocephaly. Child's Nervous System. 2006;22(10):1249-55.
24. Lipina R, Reguli Š, Nováčková L, Podešvová H, Brichtová E. Relation between TGF-β 1 levels in cerebrospinal fluid and ETV outcome in premature newborns with posthemorrhagic hydrocephalus. Child's Nervous System. 2010;26(3):333-41.
25. Morales DM, Townsend RR, Malone JP, Ewersmann CA, Macy EM, Inder TE, et al. Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity. Molecular & Cellular Proteomics. 2012;11(6):M111. 011973.
26. Morales DM, Holubkov R, Inder TE, Ahn HC, Mercer D, Rao R, et al. Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity. PloS one. 2015;10(3):e0115045.
27. Strahle JM, Garton T, Bazzi AA, Kilaru H, Garton HJ, Maher CO, et al. Role of hemoglobin and iron in hydrocephalus after neonatal intraventricular hemorrhage. Neurosurgery. 2014;75(6):696-706.
28. Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A. Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatric research. 2001;49(2):208-12.
29. Strahle JM, Mahaney KB, Morales DM, Buddhala C, Shannon CN, Wellons III JC, et al. Longitudinal CSF Iron Pathway Proteins in Post‐Hemorrhagic Hydrocephalus: Associations with Ventricle Size and Neurodevelopmental Outcomes. Annals of Neurology. 2021.
30. Whitelaw A. Endogenous fibrinolysis in neonatal cerebrospinal fluid. European journal of pediatrics. 1993;152(11):928-30.
31. Whitelaw A, Creighton L, Gaffney P. Fibrinolysis in cerebrospinal fluid after intraventricular haemorrhage. Archives of disease in childhood. 1991;66(7 Spec No):808-9.
32. Cerda M, Manterola A, Ponce S, Basauri L. Electrolyte levels in the CSF of children with nontumoral hydrocephalus. Child's Nervous System. 1985;1(6):306-11.
33. Nagy G, Molnar L, Kovács T, Nyako G, Rochlitz S. Elektrolytgehalt des Liquor cerebrospinalis bei Hydrocephalus. Archiv für Psychiatrie und Nervenkrankheiten. 1979;226(4):319-24.
34. Kiviranta T, Tuomisto L, Airaksinen EM. Osmolality and electrolytes in cerebrospinal fluid and serum of febrile children with and without seizures. European journal of pediatrics. 1996;155(2):120-5.
35. Wibroe EA, Yri HM, Jensen RH, Wibroe MA, Hamann S. Osmolality of cerebrospinal fluid from patients with idiopathic intracranial hypertension (IIH). Plos one. 2016;11(1):e0146793.
36. Ohman Jr JL, Marliss EB, Aoki TT, Munichoodappa CS, Khanna VV, Kozak GP. The cerebrospinal fluid in diabetic ketoacidosis. New England Journal of Medicine. 1971;284(6):283-90.
37. Akaishi T, Takahashi T, Nakashima I, Abe M, Aoki M, Ishii T. Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions. Neural regeneration research. 2020;15(5):944.
38. Krishnamurthy S, Li J, Schultz L, Jenrow KA. Increased CSF osmolarity reversibly induces hydrocephalus in the normal rat brain. Fluids and Barriers of the CNS. 2012;9(1):1-8.
39. Maraković J, Orešković D, Radoš M, Vukić M, Jurjević I, Chudy D, et al. Effect of osmolarity on CSF volume during ventriculo-aqueductal and ventriculo-cisternal perfusions in cats. Neuroscience letters. 2010;484(2):93-7.
40. Patra K, Wilson-Costello D, Taylor HG, Mercuri-Minich N, Hack M. Grades I-II intraventricular hemorrhage in extremely low birth weight infants: effects on neurodevelopment. The Journal of pediatrics. 2006;149(2):169-73.
41. Wellons JC, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni AV, Limbrick DD, et al. Shunting outcomes in posthemorrhagic hydrocephalus: results of a Hydrocephalus Clinical Research Network prospective cohort study. Journal of Neurosurgery: Pediatrics. 2017;20(1):19-29.
42. Ezz-Eldin ZM, Hamid TAA, Youssef MRL, Nabil HE-D. Clinical risk index for babies (CRIB II) scoring system in prediction of mortality in premature babies. Journal of clinical and diagnostic research: JCDR. 2015;9(6):SC08.
43. Feudtner C, Hays RM, Haynes G, Geyer JR, Neff JM, Koepsell TD. Deaths attributed to pediatric complex chronic conditions: national trends and implications for supportive care services. Pediatrics. 2001;107(6):e99-e.
44. Manktelow BN, Draper ES, Field DJ. Predicting neonatal mortality among very preterm infants: a comparison of three versions of the CRIB score. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2010;95(1):F9-F13.
45. Parry G, Tucker J, Tarnow-Mordi W, Group UNSSC. CRIB II: an update of the clinical risk index for babies score. The Lancet. 2003;361(9371):1789-91.
46. Simon TD, Hall M, Riva-Cambrin J, Albert JE, Jeffries HE, LaFleur B, et al. Infection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United States. Journal of Neurosurgery: Pediatrics. 2009;4(2):156-65.
47. Han RH, McKinnon A, CreveCoeur TS, Baksh BS, Mathur AM, Smyser CD, et al. Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. Child's Nervous System. 2018;34(11):2203-13.
48. Simon TD, Butler J, Whitlock KB, Browd SR, Holubkov R, Kestle JR, et al. Risk factors for first cerebrospinal fluid shunt infection: findings from a multi-center prospective cohort study. The Journal of pediatrics. 2014;164(6):1462-8. e2.
49. Greenberg JK, Olsen MA, Yarbrough CK, Ladner TR, Shannon CN, Piccirillo JF, et al. Chiari malformation Type I surgery in pediatric patients. Part 2: complications and the influence of comorbid disease in California, Florida, and New York. Journal of Neurosurgery: Pediatrics. 2016;17(5):525-32.
50. Morales DM, Smyser CD, Han RH, Kenley JK, Shimony JS, Smyser TA, et al. Tract-specific relationships between cerebrospinal fluid biomarkers and periventricular white matter in posthemorrhagic hydrocephalus of prematurity. Neurosurgery. 2021;88(3):698-706.
51. Artru AA. Isoflurane does not increase the rate of CSF production in the dog. The Journal of the American Society of Anesthesiologists. 1984;60(3):193-7.
52. Melton J, Nattie E. Brain and CSF water and ions during dilutional and isosmotic hyponatremia in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1983;244(5):R724-R32.
53. Artru AA. Reduction of cerebrospinal fluid pressure by hypocapnia: changes in cerebral blood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes. Journal of cerebral blood flow & metabolism. 1987;7(4):471-9.
54. Kent AL, Wright IM, Abdel-Latif ME. Mortality and adverse neurologic outcomes are greater in preterm male infants. Pediatrics. 2012;129(1):124-31.
55. Shankaran S, Lin A, Maller-Kesselman J, Zhang H, O'Shea TM, Bada HS, et al. Maternal race, demography, and health care disparities impact risk for intraventricular hemorrhage in preterm neonates. The Journal of pediatrics. 2014;164(5):1005-11. e3.
56. Linder N, Haskin O, Levit O, Klinger G, Prince T, Naor N, et al. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case-control study. Pediatrics. 2003;111(5):e590-e5.
57. Krishnamurthy S, Li J, Schultz L, McAllister JP. Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus. Cerebrospinal fluid research. 2009;6(1):1-9.
58. Krishnamurthy S, Tichenor MD, Satish AG, Lehmann DB. A proposed role for efflux transporters in the pathogenesis of hydrocephalus. Croatian medical journal. 2014;55(4):366-76.
59. Praetorius J, Damkier HH. Transport across the choroid plexus epithelium. American Journal of Physiology-Cell Physiology. 2017;312(6):C673-C86.
60. Koeppen B, Stanton B. Physiology of body fluids. Renal Physiology, Mosby Physiology Monograph Series, 4th edn Elsevier Inc; Philadelphia, PA. 2013;206:75-7.
61. Shah MM, Mandiga P. Physiology, Plasma Osmolality and Oncotic Pressure. 2019.
62. Hochstetler AE, Smith HM, Preston DC, Reed MM, Territo PR, Shim JW, et al. TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus. JCI insight. 2020;5(18).
63. Klarica M, Miše B, Vladić A, Radoš M, Orešković D. “Compensated hyperosmolarity” of cerebrospinal fluid and the development of hydrocephalus. Neuroscience. 2013;248:278-89.
64. Sørensen P, Gjerris A, Hammer M. Cerebrospinal fluid vasopressin in neurological and psychiatric disorders. Journal of Neurology, Neurosurgery & Psychiatry. 1985;48(1):50-7.
65. Borenstein-Levin L, Koren I, Kugelman A, Bader D, Toropine A, Riskin A. Post-hemorrhagic hydrocephalus and diabetes insipidus in preterm infants. Journal of Pediatric Endocrinology and Metabolism. 2014;27(11-12):1261-3.
66. Thakore P, Dunbar A, Lindsay E. Central diabetes insipidus: A rare complication of IVH in a very low birth weight preterm infant. Journal of neonatal-perinatal medicine. 2019;12(1):103-7.
67. Van der Kaay DC, Van Heel WJ, Dudink J, van den Akker EL. Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing. Journal of Pediatric Endocrinology and Metabolism. 2014;27(7-8):769-71.
68. Shiel RE, Pinilla M, Mooney CT. Syndrome of inappropriate antidiuretic hormone secretion associated with congenital hydrocephalus in a dog. Journal of the American Animal Hospital Association. 2009;45(5):249-52.
69. Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, et al. Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nature communications. 2016;7(1):1-15.
70. Guerra MM, Henzi R, Ortloff A, Lichtin N, Vío K, Jiménez AJ, et al. Cell junction pathology of neural stem cells is associated with ventricular zone disruption, hydrocephalus, and abnormal neurogenesis. Journal of Neuropathology & Experimental Neurology. 2015;74(7):653-71.
71. de Laurentis C, Cristaldi P, Arighi A, Cavandoli C, Trezza A, Sganzerla EP, et al. Role of aquaporins in hydrocephalus: what do we know and where do we stand? A systematic review. Journal of Neurology. 2020:1-17.
72. Castañeyra-Ruiz L, González-Marrero I, Carmona-Calero EM, Abreu-Gonzalez P, Lecuona M, Brage L, et al. Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus. Clinical neurology and neurosurgery. 2016;146:76-81.
73. Ding Y, Zhang T, Wu G, McBride DW, Xu N, Klebe DW, et al. Astrogliosis inhibition attenuates hydrocephalus by increasing cerebrospinal fluid reabsorption through the glymphatic system after germinal matrix hemorrhage. Experimental neurology. 2019;320:113003.
74. Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids and Barriers of the CNS. 2014;11(1):1-16.
75. Oshio K, Watanabe H, Song Y, Verkman A, Manley GT. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1. The FASEB journal. 2005;19(1):76-8.
76. Papadopoulos MC, Verkman AS. Aquaporin water channels in the nervous system. Nature Reviews Neuroscience. 2013;14(4):265-77.
77. Hua C, Zhao G. Biomarkers in adult posthemorrhagic hydrocephalus. International Journal of Stroke. 2017;12(6):574-9.
78. Frosini M, Sesti C, Palmi M, Valoti M, Fusi F, Mantovani P, et al. Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2000;279(6):R2095-R103.
79. Kahle KT, Kulkarni AV, Limbrick Jr DD, Warf BC. Hydrocephalus in children. The lancet. 2016;387(10020):788-99.
80. Gram M, Sveinsdottir S, Cinthio M, Sveinsdottir K, Hansson SR, Mörgelin M, et al. Extracellular hemoglobin-mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage. Journal of neuroinflammation. 2014;11(1):1-15.
81. Thwaites GE, Macmullen-Price J, Chau TTH, Mai PP, Dung NT, Simmons CP, et al. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. The Lancet Neurology. 2007;6(3):230-6.
82. Jiménez AJ, Domínguez-Pinos M-D, Guerra MM, Fernández-Llebrez P, Pérez-Fígares J-M. Structure and function of the ependymal barrier and diseases associated with ependyma disruption. Tissue barriers. 2014;2(1):e28426.
83. Karimy JK, Duran D, Hu JK, Gavankar C, Gaillard JR, Bayri Y, et al. Cerebrospinal fluid hypersecretion in pediatric hydrocephalus. Neurosurgical focus. 2016;41(5):E10.
84. Damkier HH, Brown PD, Praetorius J. Cerebrospinal fluid secretion by the choroid plexus. Physiological reviews. 2013;93(4):1847-92.
85. Speake T, Whitwell C, Kajita H, Majid A, Brown PD. Mechanisms of CSF secretion by the choroid plexus. Microscopy research and technique. 2001;52(1):49-59.
86. Damkier HH, Brown PD, Praetorius J. Epithelial pathways in choroid plexus electrolyte transport. Physiology. 2010;25(4):239-49.
87. Siesjö BK. The regulation of cerebrospinal fluid pH. Kidney international. 1972;1(5):360-74.
88. Christensen HL, Barbuskaite D, Rojek A, Malte H, Christensen IB, Füchtbauer AC, et al. The choroid plexus sodium‐bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH. The Journal of physiology. 2018;596(19):4709-28.
89. Bueno D, Garcia-Fernandez J. Evolutionary development of embryonic cerebrospinal fluid composition and regulation: an open research field with implications for brain development and function. Fluids and Barriers of the CNS. 2016;13(1):1-12.
90. Vong KI, Ma TC, Li B, Leung TCN, Nong W, Ngai SM, et al. SOX9-COL9A3–dependent regulation of choroid plexus epithelial polarity governs blood–cerebrospinal fluid barrier integrity. Proceedings of the National Academy of Sciences. 2021;118(6).
91. Krishnamurthy S, Li J, Shen Y, Duncan TM, Jenrow KA, Haacke EM. Normal macromolecular clearance out of the ventricles is delayed in hydrocephalus. Brain research. 2018;1678:337-55.
92. Gato A, Alonso MI, Martín C, Carnicero E, Moro JA, De la Mano A, et al. Embryonic cerebrospinal fluid in brain development: neural progenitor control. Croatian medical journal. 2014;55(4):299-305.
93. Alonso MI, Lamus F, Carnicero E, Moro JA, de la Mano A, Fernández JM, et al. Embryonic cerebrospinal fluid increases neurogenic activity in the brain ventricular-subventricular zone of adult mice. Frontiers in neuroanatomy. 2017;11:124.
94. Gato Á, Moro J, Alonso MI, Bueno D, De La Mano A, Martin C. Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos. The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology: An Official Publication of the American Association of Anatomists. 2005;284(1):475-84.