Deep and high-stress mining results in stress transfers onto the previously placed backfill, and mines have recorded several MPa induced backfill stress. Understanding the backfill-rock mass interaction is therefore critical. Previous work considered tabular ore bodies undergoing primarily one-dimensional compression and showed how the backfill reaction curves could be estimated from oedometer laboratory test results. This work considers massive orebodies and develops a similar approach based on isotropic compression curves. Isotropic compression tests exceeding 6 MPa are carried out on samples with 3.0–11.1% binder content, tested at 1-day cure time to 28-day cure time. The compression curve is characterized in three stages: initial elastic compression up to a yield point, followed by a transition stage to the start of a final stage with a linear post-yield compression line in \({\epsilon }_{v}-\text{l}\text{o}\text{g}\left({p}^{\text{'}}\right)\) space. Because these isotropic compression tests are rare (the reported results are the first for Cemented Paste Backfill), attempts are made to relate the isotropic compression test parameters to parameters from the more commonly used Unconfined Compression Strength (UCS) tests. Unifying equations as functions of binder content and cure time are found to determine the initial yield stress and the peak strength from UCS tests. These are then related to the corresponding parameters in isotropic compression. Finally, the slope of the post-yield compression line is found as a function of UCS, thereby enabling complete reconstruction of the isotropic compression response based on parameters from carefully controlled UCS tests, as functions of binder content and cure time. Although the calibrated parameters are specific to the studied mine’s materials, the framework is general and applicable to other mines’ CPBs.