The Application of Different Breathing Training Methods in Elderly Patients With Femoral Neck Fracture: A Prospective, Randomized, and Single-Blind Study

doi:10.21203/rs.3.rs-958980/v1

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The Application of Different Breathing Training Methods in Elderly Patients With Femoral Neck Fracture: A Prospective, Randomized, and Single-Blind Study

https://doi.org/10.21203/rs.3.rs-958980/v1

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Purpose: Femoral neck fractures in elderly patients lead to reduced mobility and increased risk of pulmonary complications. The main purpose of this study is to observe the forced expiratory volume in the first second(FEV1), forced vital capacity(FVC), blood oxygen saturation(SPO₂), pulmonary complications, and hospitalization days in elderly patients with femoral neck fractures, and to evaluate the use of lung function trainers to train elderly patients’ lung function effect and feasibility.

Methods: This is a prospective, randomized and single-blind study. 108 elderly patients with femoral neck fractures over 70 years old were randomly divided into a conventional group and a lung function trainer group. The conventional group received effective cough training and lip-reducing breathing training, and the lung function trainer group received effective cough training and lung function training. Until 2 weeks after surgery. The main outcomes are forced expiratory volume in the first second, forced vital capacity, and blood oxygen saturation. The secondary outcomes are pulmonary complications and the hospitalization days.

Results: 50 subjects in the conventional group and 51 subjects in the lung function trainer group completed the study. On the 3rd and 7th day of training, the FVC of the lung function trainer group was higher than that of the conventional group (2.94±0.40vs.2.72±0.34,P<0.05；3.02±0.40vs.2.86±0.34,P<0.05), and the FVE1 of the the lung function trainer group was higher than that of the conventional group (1.99±0.37vs.1.80±0.42，P＜0.05；2.14±0.39vs.1.94±0.43,＜0.05), and the blood oxygen saturation of the lung function trainer group was higher than that of the conventional group ( 97.10±1.35vs.96.28±1.21；97.47±1.35vs.96.86±1.36,P＜0.05), 4 cases of pneumonia in the conventional group, no one in the lung function trainer group was diagnosed with pneumonia, and the hospitalization days in the lung function trainer group was less than that in the conventional group (15.55±1.45VS.17.2±2.58,P<0.05).

Conclusion: For elderly patients with femoral neck fracture, the use of lung function training device to strengthen respiratory muscle function training during perioperative period can improve the patient's lung function in a short period of time, reduce the complications of respiratory system infection, and shorten the hospitalization days. It is worthy of clinical application.

Orthopedics

Orthopedic Surgery

Old age

Femoral neck fracture

Lung function training

Lung function trainers

Forced expiratory volume in the first second

Forced vital capacity

Blood oxygen saturation

Pulmonary complications

Hospitalization days

Femoral neck fractures are a common clinical trauma and often occur in elderly patients. With the increase of life expectancy, the incidence rate is also increasing, especially in developed countries and regions where the elderly population is increasing rapidly. According to Melton's statistics^[1], the number of hip fractures worldwide was 10,000 in 1990. By 2025, this number is expected to reach 4 million and by 2050 it can reach 6.3 million. In the United States, there are currently about 329,000 hip fractures in the elderly each year, and the number will exceed 500,000 by 2040 ^[2]. Due to the progressive decline of vital life organs to varying degrees, coupled with anesthesia, surgical trauma, pain and other reasons, elderly patients can easily cause perioperative respiratory failure, and have a higher probability of pulmonary complications.Respiratory failure is ultimately life-threatening. Although conventional respiratory function training (Knocking back, Coughing, and Expectoration) can improve the lung function of patients after surgery to varying degrees ^[3], but the effect on elderly patients is not ideal ^[4]. How to reduce the incidence of pulmonary complications in elderly patients during perioperative period, early prevention and postoperative strengthening of lung care are particularly important ^[5]. Respiratory function training is a new technique applied to patients undergoing perioperative surgery of the chest and abdomen in recent years. After breathing function training, it can enhance the patient's tolerance to surgery, improve the lung function of postoperative patients, and reduce postoperative pulmonary complications. Incidence ^[6–7]. This study compared the effects of different breathing training methods on perioperative prevention of pulmonary complications in elderly patients with femoral neck fractures, and provided an effective and reasonable training method for clinical care. The report is as follows.

Design overview

This is a prospective, randomized, single-blind clinical study, approved by the Ethics Committee of Zhongshan Hospital Affiliated to Dalian University.

Subjects

This study recruited 108 elderly patients over 70 years of age who had unilateral femoral neck fractures and planned to undergo artificial total hip replacement surgery. The inclusion criteria as follows: (1) The preoperative lung function test results should meet one of the following criteria as a minimum: forced expiratory volume in the first second (FEV1)> 2L, forced expiratory volume in the first second/forced vital capacity (FEV1/FVC)> 50%; Maximum minute ventilation (MVV)>80L/min or>50% of predicted value; Residual air volume/Maximum minute ventilation (RV/TIC)<50%, estimated postoperative FEV1>0.8L; (2) First admission Arterial blood gas PaO2 in resting state: 60-70mmHg; (3) No lung infection. The exclusion criteria were as follows: (1) Patients with severe comorbidities such as heart, brain, liver, and kidney before surgery; (2) Patients with severe mental illness; (3) Arterial blood gas PaO2>71mmHg in the first resting state of admission. All patients were randomly divided into a control group (54 cases) and a lung function training device group (54 cases). In addition, patients with unexpected or critical situations during treatment withdrew from the study.

Program

All measured values are measured by the same nurse (blind) using a portable spirometer to measure all patients (blind) FEV1, FVC, MVV, RV/TIC, PaO2,SPO2, the incidence of intrapulmonary infection within two weeks, and the hospitalization days. All interventions are carried out by professionally trained nurses (not blind).

Conventional group(CG)

Receive lip constriction breathing training and effective cough training.Lip constriction breathing training: The technique of reduced lip breathing is to extend the expiration time, increase the airway pressure, and delay the collapse of the airway through the weak resistance formed by the shrinking lip. The patient closes the mouth and breathes in through the nose, then slowly exhales through the shrinking lip (whistle-like) while contracting the abdomen. The ratio of exhalation to inhalation time is 1:2 or 1:3. The size of the shrinking lip and the expiratory flow rate are suitable to be able to make the candle flame that is 15-20cm away from the lip and level with the height of the lip incline with the airflow without being extinguished. Effective cough training: The patient takes the supine position, the upper body can be slightly forward, inhale slowly and deeply, hold the breath for a few seconds, and then cough 2-3 times, contract the abdominal muscles when coughing, retract the abdominal wall, or press with their own hands On the upper abdomen, help cough, stop coughing, shrink the lips to exhale as much as possible, inhale slowly and deeply, repeat the above actions, do it 2-3 times, rest for a few minutes and start again.

Lung function trainer group(LG)

Receive effective cough training and use lung function trainer for respiratory muscle function training. The professionally trained nurses introduces the lung function training device to the patient, informs the patient of the precautions and teaches the patient to use it. How to use:(1)Take out the lung function trainer, connect the threaded connection tube with the interface and bite of the shell, and place it vertically; (2)Inspiratory training: the base with the word "suction" is placed below, breathing in the mouth, breathing in with a deep and even flow rate of inspiration to keep the floating ball rising, and as long as possible to keep it, after 10-15 minutes of inspiratory training, to rest with normal breathing;(3)Exhalation training: place the base with the word "blow" on the bottom, do exhalation training, with deep and even exhalation flow rate to keep the floating ball rising, and keep it as long as possible, after 10-15 minutes of exhalation training, rest with normal breathing .

Fifty-one subjects (age, 73.87±4.18 years old) in the LG and 50 subjects (age, 74.7±4.061 years old) in the CG completed the study, of which 7 patients were discharged prematurely and withdrawal from the trial due to electrolyte imbalance, postoperative delirium, or arrhythmia. The general information used to treat subjects is shown in table 1.

Table 1 Comparison of general information in the two groups of patients.

	Control n = 50	Experiment n = 51	t 或 χ2	P
Age (years)	74.66±3.68	74.63±3.47	0.05	0.96
Sex, female (n, %)	26（52）	29（56.86）	0.24	0.62
Complications
diabetes	6	5	0.44	0.51
hypertension	20	18	0.48	0.48
PaO2	65.14±2.81	64.84±3.01	1.51	0.61

Spirometer tests

The FVC at three time points is shown in Table 2.The results of repeated measurement ANOVA showed that the difference of FVC at different time was statistically significant (F = 42.43, P < 0.001). FVC increased gradually with the extension of time. There was no significant difference in FVC between the two groups of patients at admission (t=1.05,P=0.30). The FVC of the LG was higher than that of the CG at 3 days after operation (t=-3.07,P<0.05), 7 days after operation the FVC of the LG is higher than that of the CG(t=-2.16,P<0.05)

Table 2 FVC comparison

Group

The day of admission

After 3 days

After 7 days

P value*

3.1±0.36

2.72±0.34

2.86±0.34

42.43

<0.001

3.02±0.40

2.94±0.40

3.02±0.40

*P-value for repeated ANOVA.

The FEV1 at three time points is shown in Table 3. The results of repeated measurement ANOVA showed that the difference of FEV1 at different time was statistically significant (F = 21.26, P < 0.001). FEV1 increased gradually with the extension of time.There was no statistically significant difference in FVE1 between the two groups at admission (t=0.24，P=0.81). FVE1 in the LG was higher than that in the CG at 3 days after operation (t=-2.324,P<0.05), 7 days after operation the FVE1 of the LG was higher than that of the CG (t=-2.405，P<0.05)

Table 3 Comparison of FEV1

Group

The day of admission

After 3 days

After 7 days

2.18±0.46

1.80±0.42

1.94±0.43

2.16±0.39

1.99±0.37

2.14±0.39

*P-value for repeated ANOVA.

Blood oxygen saturation(SPO2)

The blood oxygen saturations at the three time points are shown in Table 4. The results of repeated measurement ANOVA showed that the difference of SPO2 at different time was statistically significant (F = 8.433, P < 0.001). SPO2 increased gradually with the extension of time.There was no statistically significant difference in SPO2 between the two groups before surgery (t=0.755，P=0.45), and the SPO2 in the LG was higher than that in the CG (t=-3.207,P<0.05) after 3 days. 7 days after operation the SPO2 in the LG was higher than that in the CG (t=-2.271，P<0.05)

Table 4 Comparison of blood oxygen saturation (%)

Group

The day of admission

After 3 days

After 7 days

98.14±1.56

96.28±1.21

96.86±1.36

97.9±1.63

97.10±1.35

97.47±1.35

*P-value for repeated ANOVA.

Pneumonia, hospitalization days

The comparison of pneumonia and hospitalization days between the two groups is shown in Table 5. After two weeks of observation, 4 patients in the CG were diagnosed with pneumonia, and no one in the LG was diagnosed with pneumonia

(χ2=4.248,P=0.039). The hospitalization days in the LG was lower than that of the CG (t=3.98,P<0.001)

Table 5 Comparison of pneumonia and hospitalization days

Group

Pneumonia

n(%)

hospitalization days

4(8)

17.2±2.58

0(0)

15.55±1.45

Femoral neck fractures tend to occur in elderly patients with osteoporosis. With the advent of an aging society, the number of elderly people in the world is increasing, and the number of osteoporotic patients is increasing, and the incidence of femoral neck fractures is also increasing year by year. Elderly patients with femoral neck fractures often have medical diseases. Long-term bed rest are prone to serious complications such as urinary tract infections, bedsores, pulmonary infections, and lower extremity venous thrombosis. In severe cases, they can be life-threatening. Therefore, early surgical treatment should be performed if there is no contraindication to surgery. With the widespread development of total hip arthroplasty, its surgical indications have been gradually relaxed, and more and more elderly patients undergo artificial total hip replacement. This operation can restore the function of the affected limb, improve the quality of life of the patient, avoid complications such as fracture nonunion, femoral head necrosis, and get out of bed early to reduce the complications of bed rest ^[9]. Elderly patients with femoral neck fractures have the following pathophysiological characteristics before surgery: lung function degradation, different degrees of ventilation or ventilation dysfunction, respiratory mucosa atrophy, cilia dyskinesia, reduced airway clearance; increased goblet cells in the airway mucosa, The secretions are many and sticky; most of them are combined with various medical diseases, which require medical treatment before surgery. The bed time is relatively long, which may cause slow recovery of respiratory function during perioperative period, decrease of respiratory muscle strength, and significant increase of lung infection. Therefore, the prevention and treatment of perioperative lung infections in elderly patients with fractures is particularly important, and one of the methods to improve respiratory function is to conduct preoperative and postoperative respiratory function training.

The application of pulmonary function breathing training device can effectively increase the FEV1, FVC and PaO2 of elderly patients during perioperative period, and increase the effective alveolar ventilation. The principle is that the lung function trainer can improve the uneven distribution of inhaled gas and hypoxia through training. By actively and slowly inhaling and exhaling air, reducing the breathing frequency, increasing the internal pressure of the trachea, preventing premature pressure of the bronchi and small bronchi, effectively eliminating residual lung gas, improving the ventilation / blood flow imbalance, increasing tidal volume and increasing effective ventilation The amount of functional residual gas reduces the dilution of fresh air inhaled and increases the alveolar carbon dioxide partial pressure, thereby improving gas exchange and improving the patient's ventilation function; full expansion of the thoracic cavity and increased negative pressure in the pleural cavity are conducive to lung expansion and atrophy In order to further prevent atelectasis, atelectasis or atelectasis can effectively prevent atelectasis, maximize lung function, and increase alveolar oxygen uptake capacity, thereby reducing the occurrence of hypoxemia and effectively preventing atelectasis and Pulmonary infections ^[10–11].

Mills et al. ^[12] conducted an 8-week inspiratory muscle training for 65-75-year-old patients and found that the strength of the inspiratory muscle was significantly improved, and pointed out that inspiratory muscle training in the elderly with weak and poor respiratory function groups, inspiratory The improvement of muscle function is more obvious. Moreover, inspiratory muscle training can reduce the concentration of IL-1 and IL-6 by enhancing the function of respiratory muscles, thereby reducing the systemic inflammatory response ^[13]. Other scholars have also confirmed that inspiratory muscle training reduces lung infections while improving lung function, esophageal cancer, and respiratory dysfunction after abdominal surgery ^[14–16]. In this study, patients in the LG received routine rehabilitation training while adding pulmonary respiratory muscle function training, and it was found that respiratory function was significantly improved, and the incidence of pulmonary infection in the perioperative period was reduced. Compared with the CG, the difference was statistically significant (P < 0.05) (Table 5).The author believes that the reason may be that respiratory muscle training enhances the endurance of diaphragm and intercostal muscles, increases the alveolar oxygen carrying capacity and effective ventilation, improves respiratory function, and prevents and reduces the occurrence of lung infections.

On the basis of routine lung care, combined with respiratory muscle training can maximize the active contraction of respiratory muscles, re-mobilize the airway cilia clearance function, increase airway clearance and defense capabilities, and enhance airway mucosal function and secretion Reducing and eliminating functional enhancement is an effective way to prevent postoperative complications. Celli et al. ^[17] found that compared with the control group, the comprehensive training group had significantly lower hospital stay for postoperative pulmonary complications. The results of the study in the CG and the LG showed that FEV1, FVC and SPO2 in the LG were higher than those in the CG at 3 and 7 days after operation(P < 0.05),the difference was statistically significant. It shows that in the perioperative period, the use of lung function training equipment can effectively improve lung function and avoid pulmonary complications.

In summary, the combined use of lung function breathing exercisers on the basis of perioperative routine care for elderly patients not only quantifies the recovery of patients 'lung function, but also increases the patient's initiative and enthusiasm for lung function training, which leads to patients' Good psychological motivation, enhance patients' self-confidence and fun in respiratory function exercise, further improve lung function, shorten the waiting time for surgery and reduce postoperative respiratory complications, and effectively save medical resources.

The study time is relatively short, and the control time needs to be further extended to observe the treatment effect.

The use of lung function training devices on the basis of perioperative routine care for elderly patients with fractures can improve the lung function of patients in a short period of time, improve the patient's surgical tolerance, reduce the complications of respiratory infections, and increase the success rate of surgery. Shorten the length of hospitalization, reduce the financial burden of patients, and make it return to social life more quickly.

FEV1: Forced expiratory volume in the first second; FVC: Forced vital capacity; MVV: Maximum minute ventilation; RV: Residual volume; TIC: Maximum minute ventilation; PaO2: Oxygen partial pressure; SPO2: Blood oxygen saturation;CG: Conventional group;LG:Lung function trainer group.

Acknowledgement

The author would like to thank all participants for their cooperation, thank all participating experts for their help and suggestions, and thank the nurses who have directed and supervised the training program.

Author's contribution

Zhang Yan designed the protocol and wrote the manuscript. Wang Hong supervised the research. Fan Jingmei and Fan Lin collected and analyzed relevant data, and Wang Min edited the language. All authors read and approved the final manuscript.

Funds

No.

Availability of data and materials

The dataset supporting the conclusions of this article is included within the article

Ethical approval and consent to participate

This study was approved by the Ethics Committee of Zhongshan Hospital Affiliated to Dalian University, and all participants signed written informed consent.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interestsAuthor details.

Author details

Department of Orthopedics, Zhongshan Hospital, Dalian University, No. 6, Jiefang Street, Zhongshan District, Dalian, 116000

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You are reading this latest preprint version

The Application of Different Breathing Training Methods in Elderly Patients With Femoral Neck Fracture: A Prospective, Randomized, and Single-Blind Study

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Abstract

Introduction

Materials And Methods

Results

Discussion

Limitations Of This Study

Conclusion

Abbreviations

Declarations

References

Status:

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