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Research article
Xinglong Wang
Northwest Agriculture and Forestry University
Corresponding Author
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Myostatin (MSTN) and somatostatin (SST) are negative regulate factors in the animals. Immunized animals with these proteins induce the related immune response, which could neutralize the normal inhibitory effects of these proteins. Since adenovirus was the mostly wildly used vector for delivering vaccine antigen, here, a recombinant adenovirus expressing MSTN-SST were constructed and mice were inoculated with the recombinant adenovirus. As our predicted, immunization with this adenovirus one time or two times were all induced the specific immune response and resulting in an improve growth rate and muscle mass. And boost immunization improved the effect of the immunization. Accordingly, adenovirus can be used as a vector for deliver myostatin and somatostatin gene, so as to increase animal growth rate and muscle mass of the animals.
Keywords
myostatin, somatostatin, growth rate, muscle mass
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Xinglong Wang
Northwest Agriculture and Forestry University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
The most recent version of this article is available here.
No community comments so far
No comments provided
No comments provided
No comments provided
No comments provided
Version 1
Posted 17 Dec, 2019
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Small Animal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Myostatin (MSTN) and somatostatin (SST) are negative regulate factors in the animals. Immunized animals with these proteins induce the related immune response, which could neutralize the normal inhibitory effects of these proteins. Since adenovirus was the mostly wildly used vector for delivering vaccine antigen, here, a recombinant adenovirus expressing MSTN-SST were constructed and mice were inoculated with the recombinant adenovirus. As our predicted, immunization with this adenovirus one time or two times were all induced the specific immune response and resulting in an improve growth rate and muscle mass. And boost immunization improved the effect of the immunization. Accordingly, adenovirus can be used as a vector for deliver myostatin and somatostatin gene, so as to increase animal growth rate and muscle mass of the animals.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
This is a list of supplementary files associated with this preprint. Click to download.
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