Burden of Risk Factors For Human Immunodeficient Virus Among Women of Reproductive Age In Sierra Leone: A 2019 Nationwide Survey

doi:10.21203/rs.3.rs-968805/v1

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Burden of Risk Factors For Human Immunodeficient Virus Among Women of Reproductive Age In Sierra Leone: A 2019 Nationwide Survey

https://doi.org/10.21203/rs.3.rs-968805/v1

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Background and aim: For over 40 years of the HIV/AIDS global epidemic, no effective cure nor vaccine is yet available, making the current control strategies focused on curbing new infections through risk reduction. The study aimed to determine the burden (prevalence) of HIV risk factors and their associated socio-demographics among women of reproductive age in Sierra Leone.

Methods: We used weighted data from the Sierra Leone Demographic and Health Survey (SLDHS) of 2019 for 12,005 women aged 15-49 years. Multistage sampling was used to select study participants. Exposure to HIV risk factors was considered if a woman reported at least one of the following; having multiple sexual partners, transactional sex, non-condom use for the unmarried, and having other sexually transmitted infections (STIs). We, then, conducted multivariable logistic regression to explore the associated socio-demographics. All the analyses were done using SPSS (version 25).

Results: Of the 12,005 women, 38.1% (4577/12005) (95% confidence interval (CI): 37.3-39.0) had at least one of the four risk factors. Women of 15 to 19 years (adjusted odds ratio (AOR)=1.34, 95% CI: 1.00-1.80) and 20 to 34 years (AOR=1.25, 95% CI: 1.05-1.49) had more odds of having HIV risk factors compared to those of 35 to 49 years. Urban residents (AOR=1.49, 95% CI: 1.17-1.89) and those from the Northwestern region (AOR=1.81, 95% CI: 1.26-2.60) were also more likely to encounter HIV risk factors compared to their respective counterparts. Moreover, unmarried women (AOR=111.17, 95% CI: 87.55-141.18) and those working (AOR=1.38, 95% CI: 1.14-1.67) also had higher odds of having HIV risk factors, compared to their respective counterparts. Sex of household head and parity were also significant associates.

Conclusions: More than a third of women in Sierra Leone had encountered at least one HIV risk factor, and this was associated with age, place of residence, region, marital status, working status, household head and parity. There is a need for strengthening HIV/AIDS education programs, laws and policies targeting the young, working, unmarried and urban-resident women.

Infectious Diseases

HIV/AIDS

Women

Risk-factors

Burden

DHS

Sierra Leone.

Over 40 years since its identification, the Human immunodeficiency virus (HIV) is still a global public health concern and one of the major causes of death, especially in developing countries [1]. According to a recent Joint United Nations Programme on HIV/AIDS (UNAIDS) report, over 37 million people globally were living with HIV in 2020, 1.5 million became infected and close to 1 million died due to acquired immunodeficiency syndrome (AIDS) related illnesses [1]. Africa still shares the biggest burden of HIV/AIDS, whereby over two-thirds of people living with HIV globally are found in sub-Saharan Africa [2].

In Sierra Leone, a small low-income West African country with a population size of around 8 million, the prevalence of HIV is around 1.7%, with a higher burden in Freetown- the capital [3, 4, 5]. Like in other countries, the key population groups in Sierra Leone include female sex workers, their partners and clients, long-distance truck drivers, members of the fishing community, men who have sex with men, transgenders, uniformed armed personnel, prisoners, migrants, and injection drug users [3]. Moreover, often the under-looked vulnerable group are the women since they are not classified under the key population groups. HIV/AIDS is shown to disproportionately affect women, where they account for more than half (55%) of people living with HIV/AIDS globally [2]. A similar trend has also been reported in Sierra Leone with women having a higher HIV prevalence than men (1.8% vs 1.3%) [6]. Besides the known risk of mother to child transmission, HIV/AIDS is also reported to have other adverse pregnancy complications [7] and is the leading cause of death among women of reproductive age [8]. In sub-Saharan Africa, the disproportionate burden of HIV/AIDS among women is attributed to lack of power, early marriages, coerced first sex, limited access to reproductive health services, extreme poverty, sexual violence, wars and conflict [9, 10].

Generally, there is a dearth of literature on the epidemiological characteristics of HIV/AIDS from Sierra Leone, with a few studies focusing on HIV prevalence, testing, associated factors, or other aspects in either general or some key population groups but not women [6, 11–16]. Nevertheless, several factors/behaviours have been documented in Sierra Leone and elsewhere to increase the risk of HIV, which include; having multiple sexual partners, other sexually transmitted infections (STIs), inconsistent condom use, engaging in transactional sex, alcohol and drug use before/during sex, among others [11, 13, 17–20].

Given the considerable vulnerability of women to HIV/AIDS, we, therefore, aimed to determine the burden, in terms of prevalence, of HIV risk factors and their associated socio-demographics among women of reproductive age in Sierra Leone, using a nationwide dataset. We hypothesized that several socio-demographic characteristics are associated with HIV risk factors/behaviours. Thus establishing the magnitude of these risk factors and their associates would be vital in informing targeted interventions to address this global epidemic.

Study design and sampling methods

The Sierra Leone Demographic and Health Surveys (SLDHS) are cross-sectional surveys that are periodically conducted to obtain information on demographic, health and nutritional indicators of non-elderly adults and children. The latest survey was conducted over four months between May 2019 and August 2019 [5]. This national survey used a stratified, two-stage cluster sampling design with the first stage having 578 enumeration areas (EAs) (214 urban and 364 rural) selected leading to 13,872 households [5]. Using interviewer-administered questionnaires, the survey obtained sociodemographic information about the respondents. A detailed explanation of the sampling process is available elsewhere [5]. Women aged 15-49 years who were either permanent residents or visitors who had stayed in the selected households the night before the survey were eligible for interviews with a total of 15,574 women being interviewed. Of these, a weighted sample of 12,005 had been sexually active within 12 months preceding the survey and was included in this secondary analysis as shown in Table 1. Written informed consent was provided by all participants of the survey. Written permission to access the whole SLDHS database was obtained through the DHS program website [21].

Variables Of The Study

Dependent variable

Four variables from the SLDHS were used in this study to measure the risk factors for HIV and these included; 1) engaging in sex with more than one partner in the past 12 months, 2) engaging in transactional sex in the past 12 months, 3) not using a condom during the most recent intercourse for those who were not married, and 4) having had a sexually transmitted infection [17, 18]. The total number of risk factors per woman was not a variable in the SLDHS but was generated by first giving a score of 1 for every exposure to an HIV risk factor and a score of 0 for every non-exposure, and then summing up the scores for each woman. The minimum possible score is 0 while the maximum possible score is 4. Exposure to any of the four risk factors for HIV was categorized as a binary (Yes/No) outcome and women were considered to have been exposed to risk factors for HIV if they reported any of the four behaviours. The use of alcohol/being drunk during the last sexual intercourse was not included because the data was not available in the SLDHS data set.

Independent Variables

Nineteen explanatory variables were used and included: Maternal age (15-19 years, 20–34 years and 35–49 years), Wealth index (poorest, poorer, middle, richer and richest quintiles), place of residence (urban and rural), region (Northern, Eastern, Southern, Western and Northwestern), level of education (no education, primary education, and post-primary education), household size (less than seven members and seven and above members), sex of household head (male or female), working status (not working and working), marital status (married including those in formal and informal unions, and not married). Religion was categorised as Muslims and Christians and others, problems seeking permission and distance to health facility were categorised as a big problem and no big problem while exposure to mass media was categorised as yes and no (if exposed to any of TV, radio, internet and newspapers), and visited by field worker or visited a health facility were categorised as yes and no, parity (less than 2, 2-4 and 5 and above).

Statistical analysis

The study first presented descriptive statistics of the background characteristics and risk factors of HIV of the study sample. This study first examined the proportion of women that reported ever engaging in risk factors for HIV and then examined the factors associated with these risk factors. Bivariable and multivariable logistic regression analyses were conducted and variables found significant at p-value less than 0.25 in the bivariable analysis and not strongly collinear with other independent variables were included as candidate variables in the multivariable model [22]. Multi-collinearity was assessed using variance inflation factor (VIF) and wealth index was excluded in the multivariable model because it had VIFs above 3 with marital status, age, working, exposure to newspapers, internet, parity and problems with distance and seeking permission to healthcare. Analysis was carried out based on the weighted count to account for the unequal probability sampling in different strata and to ensure the representativeness of the survey results at the national and regional levels. In order to account for the multi-stage cluster study design, we used SPSS (version 25.0) statistical software complex samples package incorporating the following variables in the analysis plan to account for the multistage sample design inherent in the DHS dataset: individual sample weight, sample strata for sampling errors/design, and cluster number [23–25]. Adjusted odds ratios (AOR), 95% confidence intervals (CI) and p-values were calculated with statistical significance level set at p-value < 0.05.

Sociodemographic characteristics of study participants

In this study, a weighted sample of 12,005 women was used as shown in Table 1. The majority of women were aged 20-34 years (51.8%), had visited a health facility within 12 months preceding the survey (56.2%), working (73.9%), Muslims (76.6%), resided in rural areas (55.4%), no education (48.6%) and were married (70.8%). Most women had no exposure to mass media with 92.1%, 84.7%, 72.1% and 53.9% not being exposed to newspapers/magazines, internet, TV, and Radio respectively.

Out of the 12,005 women, 3,289 (27.4%, 95% CI: 26.6-28.2) were unmarried and had not used condom for their most recent sexual intercourse, 1,490 (12.4%, 95% CI: 11.9-13.1) had a sexually transmitted infection, 580 (4.8%, 95% CI: 4.4-5.2) had multiple sexual partners, 154 (6.6%, 95% CI: 5.5-7.4) had transactional sex and 4,577 (38.1%, 95% CI: 37.3-39.0) had any of the four risk factors as shown in Table 2.

Table 1

Socio-demographic characteristics of reproductive aged women in Sierra Leone as per the 2019 SLDHS
Characteristics	N = 12005	%
Age
15 to 19	1716	14.3
20 to 34	6216	51.8
35 to 49	4073	33.9
Visited by fieldworker
No	8539	71.1
Yes	3466	28.9
Visited health facility
No	5254	43.8
Yes	6751	56.2
Residence
Rural	6654	55.4
Urban	5351	44.6
Region
Western	2841	23.7
Southern	2260	18.8
Northwestern	1973	16.4
Northern	2587	21.5
Eastern	2345	19.5
Religion
Islam	9193	76.6
Christianity and others	2812	23.4
Sex household head
Male	8654	72.1
Female	3351	27.9
Household Size
7 and above	5230	43.6
Less than 7	6775	56.4
Working status
Not working	3132	26.1
Working	8873	73.9
Marital status
Married	8495	70.8
Not married	3510	29.2
Education Level
No Education	5832	48.6
Primary Education	1491	12.4
Secondary Education	4112	34.3
Tertiary	570	4.8
Wealth Index
Poorest	2156	18.0
Poorer	2283	19.0
Middle	2307	19.2
Richer	2529	21.1
Richest	2730	22.7
Parity
1-3	929	60.2
4 and above	615	39.8
Exposure to Radio
No	6471	53.9
Yes	5534	46.1
Exposure to newspapers
No	11052	92.1
Yes	953	7.9
Exposure to TV
No	8652	72.1
Yes	3353	27.9
Internet use
No	10175	84.7
Yes	1830	15.3
Permission to access healthcare
Big problem	2860	23.8
Not big problem	9146	76.2
Distance to health facility
Big problem	5243	43.7
Not big problem	6762	56.3

Table 2

Prevalence of risk factors for HIV among reproductive aged women in Sierra Leone
Risky factor	Frequency, N = 12005	Prevalence %	95% Confidence Interval
Non-condom use at last sexual intercourse for unmarried women	3289	27.4	26.6-28.2
Transactional sex^a	154	6.6	5.5-7.4
Sexually transmitted infection	1490	12.4	11.9-13.1
Multiple sexual partners	580	4.8	4.4-5.2
Any of the above	4577	38.1	37.3-39.0
^aMissing 9669 responses

Factors Associated With Risk Factors For Hiv

Results of regression analyses are detailed in Table 3. After adjusting for other factors, age, residence, region, sex of household head, working status, marital status and parity remained significantly associated with HIV risk factors.

Women of 15 to 19 years (AOR=1.34, 95% CI: 1.00-1.80) and those of 20 to 34 years (AOR=1.25, 95% CI: 1.05-1.49) were respectively, 34% and 25% more likely to have HIV risk factors compared to those of 35 to 49 years of age. Urban residents were 49% more likely to encounter HIV risk factors (AOR=1.49, 95% CI: 1.17-1.89). Compared to women in the Western region, those from the South were 33% less likely (AOR=0.67, 95% CI: 0.50-0.90) while those in the Northwest were 81% more likely (AOR=1.81, 95% CI: 1.26-2.60) to have HIV risk factors. Moreover, women from female-headed households (AOR=1.22, 95% CI: 1.03-1.44), and those working (AOR=1.38, 95% CI: 1.14-1.67) were 22% and 38% respectively, more likely to have HIV risk factors, compared to their respective counterparts. Marital status was strongly associated with HIV risk factors; whereby unmarried women were over 111% (AOR=111.17, 95% CI: 87.55-141.18) more likely to have HIV risk factors. In addition, women with parity of 0-1 (AOR=1.32, 95% CI: 1.01-1.72) and 2-4 (AOR=1.26, 95% CI: 1.01-1.57) were 32% and 26% more likely have HIV risk factors, respectively as shown in Table 3.

Table 3

Factors associated with risk factors for HIV among women of reproductive age in Sierra Leone as per the 2019 SLDHS
Characteristics	Crude model COR (95% CI)	P-value	Adjusted model AOR (95% CI)	P-value
Age
35 to 49	1		1
20 to 34	2.53 (2.32-2.88)	<0.001	1.25 (1.05-1.49)	0.012
15 to 19	13.22 (11.41-15.31)	<0.001	1.34 (1.00-1.80)	0.052
Residence
Rural	1		1
Urban	2.34 (2.08-2.62)	<0.001	1.49 (1.17-1.89)	0.001
Region
Western	1		1
Southern	0.46 (0.39-0.54)	<0.001	0.67 (0.50-0.90)	0.009
Northwestern	0.69 (0.57-0.84)	<0.001	1.81 (1.26-2.60)	0.001
Northern	0.62 (0.53-0.73)	<0.001	1.25 (0.92-1.68)	0.151
Eastern	0.51 (0.44-0.59)	<0.001	0.79 (0.58-1.07)	0.125
Religion
Islam	1		1
Christianity	1.39 (1.25-1.55)	<0.001	0.98 (0.80-1.20)	0.859
Sex household head
Male	1		1
Female	2.92 (2.63-3.24)	<0.001	1.22 (1.03-1.44)	0.024
Household Size
7 and above	1		1
Less than 7	0.69 (0.62-0.76)	<0.001	0.94 (0.81-1.10)	0.435
Working status
Not working	1		1
Working	0.39 (0.35-0.43)	<0.001	1.38 (1.14-1.67)	0.001
Marital status
Married	1		1
Not married	112.26(91.74-137.37)	<0.001	111.17(87.55-141.18)	<0.001
Education Level
No Education	1		1
Primary Education	1.96 (1.68-2.28)	<0.001	1.09 (0.84-1.41)	0.526
Post-primary Education	4.60 (4.12-5.14)	<0.001	0.87 (0.73-1.04)	0.123
Wealth Index			-
Poorest	1
Poorer	1.12 (0.98-1.29)	0.109
Middle	1.40 (1.18-1.65)	<0.001
Richer	2.65 (2.25-3.13)	<0.001
Richest	2.71 (2.31-3.19)	<0.001
Parity
5 and above	1		1
2-4	1.70 (1.43-2.02)	<0.001	1.26 (1.01-1.57)	0.044
0-1	9.10 (7.71-10.73)	<0.001	1.32 (1.01-1.72)	0.043
Internet access
No	1		1
Yes	2.82 (2.50-3.17)	<0.001	0.94 (0.72-1.23)	0.655
Exposure to Radio
No	1		1
Yes	1.40 (1.28-1.54)	<0.001	1.12 (0.95-1.31)	0.171
Exposure to TV
No	1		1
Yes	1.89 (1.70-2.09)	<0.001	1.08 (0.88-1.32)	0.471
Exposure newspapers
No	1		1
Yes	2.32 (1.93-2.79)	<0.001	0.98 (0.67-1.44)	0.918
Visited by fieldworker			-
No	1
Yes	0.95 (0.86-1.06)	0.379
Visited health facility
No	1		1
Yes	0.72 (0.66-0.80)	<0.001	1.03 (0.89-1.19)	0.710
Permission to access healthcare
Big problem	1		1
Not big problem	1.32 (1.16-1.49)	<0.001	1.07 (0.87-1.31)	0.534
Distance to health facility
Big problem	1		1
Not big problem	1.44 (1.28-1.63)	<0.001	0.94 (0.76-1.16)	0.555
bold= Significant at p-value <0.05, AOR: Adjusted odds ratio, COR: Crude Odds Ratio

We conducted a secondary analysis of SLDHS data to estimate the prevalence of HIV risk factors and their socio-demographic associates among women of reproductive age in Sierra Leone. In this study, four factors were considered as potential HIV risk factors, including; non-condom use at last sexual intercourse for unmarried women, engaging in transactional sex, having other sexually transmitted infections (STIs), and having multiple sexual partners. To our knowledge, this is the first study to focus on the burden of HIV risk factors in Sierra Leone.

The study results showed that 38% of the women had encountered any of the four risk factors, 27% had non-condom use (the unmarried), 12% had other STIs, while less than 10% had engaged in transactional sex and had multiple sex partners. Although no immediate similar study to compare our results with, the overall burden of such risk factors is of significant impact in a low-income country with a high burden of other infectious diseases coupled with a weak health system [3]. With yet no effective cure nor vaccine against HIV, preventive measures aimed at reducing new infections mainly through risk-reduction are paramount in the fight against the HIV epidemic. The observed high burden of HIV risk factors, therefore, reflects a gap in the HIV/AIDS prevention and control strategies implemented in Sierra Leone, implying a need to strengthen health promotion and sexual behaviour educational programs among reproductive-aged women in the country. However, the reported prevalence, specifically, of non-condom use in this study is less than that reported by the World Health Organisation [26], and that from Tanzania [27], Malawi [28], USA [29], and China [30].

Our study also explored several socio-demographics associated with the burden of HIV risk factors, where age, parity, place of residence, region, sex of household head, marital status, and working status were found to be significant.

Women of younger age were more likely to engage in/encounter HIV risk factors compared to older women in Sierra Leone. This is similar to other studies that have individually reported age to be associated with condom use [3, 28], having other STIs [18, 31], transactional sex [18] and multiple sex partners [32]. Younger people are generally curious and common victims of peer influence thus can easily end up engaging in various risk behaviours for not only HIV but also other STIs [18, 31]. Moreover, parity was also significantly associated with HIV risk factors among women, whereby those who had ever produced fewer children were more likely to face HIV risk factors compared to their counterparts of more parity. The possible reason could be that women with no or fewer children are usually younger with less responsibilities and children to look after, so they can easily engage in risky behaviours [18, 32].

The current study results revealed that place of residence is associated with HIV risk factors, where urban women had more chances of encountering HIV risk factors. Due to the appealing and active nature of urban settings, with more entertainment avenues such as bars and clubs, women residing in these places are more exposed to risky behaviours [18]. Moreover, commercialized sexual activities and drug use tend to be more concentrated in urban areas, possibly due to the increasing trends of the urban poor and slum dwellings [18, 33]. Consistently, region was also found to be associated with HIV risk factors, where women in the Northwestern part of the country were more likely to face HIV risk factors. This may be attributed to the differential social-cultural contexts and economic developments in various parts of the country. No wonder, the Northwestern part has a higher concentration of economic development and mining activities, with a generally urban or semi-urban lifestyle [5]. Furthermore, the low employment rate of women in this region lures majority of them to engage in petty trading which exposes them to HIV risk factors during hawking from one community to another [5]. However, our results showed that women in the Southern part were less likely to encounter HIV risk factors yet the region has several fishing communities. The finding deviates from previous studies that have labelled such fishing communities as HIV/AIDS hotspots due to various unique risky behaviours in such communities [3, 34]. Region and place of residence have been reported in other studies to be associated with multiple sex partners [32], condom use [35], STIs [35], and transactional sex [33].

Participants from female-headed households were more likely to encounter HIV risk factors compared to those from male-headed households. Consistently, unmarried women also had extremely higher chances of facing HIV risk factors compared to married women. Unmarried women from female-headed households tend to have more freedom from marital obligations and autonomy to do whatever they please, unlike their married counterparts, implying they can easily engage in risky behaviours for survival or economic reasons [32]. Marital status of women has been, disaggregatively, shown in other studies to be associated with transactional sex [33], multiple sex partners [32], and having other STIs [31].

Working status also had an association with HIV risk factors, whereby working women had more chances of encountering HIV risk factors compared to non-working women. Depending on the type and nature of the employment, most informal jobs predispose women to risky behaviours, for instance, working in bars, guesthouses, and sex workers, among others [33, 36]. Furthermore, although regarded as a crucial aspect of women empowerment, employment has been shown to have other negative associates, for example, sexual violence [36]. Working status of women has been reported in previous studies to be associated with having other STIs [31], transactional sex [33], and condom use [37].

This is the first nationwide analysis that explores the burden of HIV risk factors and the associated socio-demographics, therefore, it can be used as a yardstick and motivation for further studies on the same topic in Sierra Leone and other countries. Secondly, we used the most current nationally representative dataset, thus our findings are generalizable to all women in Sierra Leone. However, our study is not without limitations, for example, the cross-sectional design only enables associations to be established but not causal relationships. There is also a possibility of recall bias due to self-reported answers, and giving false answers due to social desirability. Moreover, there was a lack of data on other key HIV risk factors such as alcohol and drug use.

The study revealed that more than a third of the reproductive aged women in Sierra Leone had encountered at least one HIV risk factor. Age, parity, place of residence, region, sex of household head, marital status, and working status were associated with the burden of HIV risk factors in the country. There is thus a need for strengthening HIV/AIDS education and sex behaviour-change communication targeting the young working unmarried women, and those residing in urban areas of the country. In addition, the existing laws and policies in the country should be strengthened to safeguard working women from the associated risks of not only HIV but also other STIs.

EA Enumeration area

AOR Adjusted Odds Ratio

CI Confidence Interval

COR Crude Odds Ratio

DHS Demographic Health Survey

SLDHS Sierra Leone Demographic Health Survey

OR Odds Ratio

SD Standard Deviation

STI Sexually Transmitted Infection

AIDS Acquired Immunodeficiecy Syndrome

HIV Human Immunodeficiency Virus

SPSS Statistical Package for Social Science

Acknowledgements

We thank the DHS program for making the data available for this study.

Funding information

No funding was obtained for this study.

Availability of data and materials

The data set used is openly available upon permission from MEASURE DHS website (URL: https://www.dhsprogram.com/data/available-datasets.cfm).

Author contributions

QS Conceived the idea, drafted the manuscript, performed analysis, interpreted the results and drafted the subsequent versions of the manuscript. JK drafted the manuscript, interpreted the results and drafted the subsequent versions of the manuscript. KK reviewed the first draft and drafted the subsequent versions of the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

High international ethical standards are ensured during MEASURE DHS surveys and the study protocol is performed in accordance with the relevant guidelines. The SLDHS 2019 survey protocol was reviewed and approved by the Sierra Leone Ethics and Scientific Review Committee and the ICF Institutional Review Board. Written informed consent was obtained from human participants and written informed consent was also obtained from legally authorized representatives of minor participants. This data set was obtained from the MEASURE DHS website (URL: https://www.dhsprogram.com/data/available-datasets.cfm) after getting their permission, and no formal ethical clearance was obtained since we conducted a secondary analysis of publicly available data.

Availability of data and materials

The data set used in this study is openly available from MEASURE DHS website and the modified data set that was used for the final analysis can be availed upon request from the corresponding author.

Consent for publication

Not applicable.

Competing interests

All authors declare that they have no competing interests.

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Burden of Risk Factors For Human Immunodeficient Virus Among Women of Reproductive Age In Sierra Leone: A 2019 Nationwide Survey

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Abstract

Introduction

Methods

Study design and sampling methods

Variables Of The Study

Dependent variable

Independent Variables

Statistical analysis

Results

Sociodemographic characteristics of study participants

Factors Associated With Risk Factors For Hiv

Discussion

Strengths And Limitations

Conclusions

Abbreviations

Declarations

References

Additional Declarations

Status:

Version 1