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Research article
Association between genetic polymorphism of XRCC7 (G6721T) and acute lymphoblastic leukemia risk
zahra beyzaei
Shiraz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8987-2555
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: One of the most important DNA double-strand break (DSBs) repair genes is XRCC7 involved in non-homologous end joining (NHEJ). It is supposed that DNA repair gene malfunction is an important risk factor in various malignancies. The XRCC7 G6721T (rs7003908) polymorphism effect were investigated on the splicing regulation that cause mRNA instability.
Objective: The aim of present hospital-based study was to investigate the association between the G6721T common genetic polymorphism of XRCC7 and risk of acute lymphoblastic leukemia (ALL).
Methods: This case–control study was performed on 99 ALL patients versus 200 healthy blood donors (children), as the control group. Controls had no history of ALL, and they were frequent-matched by age with cases. The polymorphism of XRCC7 was determined using an RFLP-PCR method.
Results: The GT (OR= 1.485, 95% CI: 0.765-2.334, P=0.243) and TT (OR= 1.655, 95% CI: 00.875-3.128, P=0.121) genotypes had no significant effect on risk of ALL, in comparison with the GG genotype. Hence, TT genotype (OR= 1.996, 95% CI: 1.033-3.858, P=0.04) after adjusting for parents smoking pattern showed a significant effect.
Conclusion: The presence of the TT genotype may be increase the risk of ALL in children when facing with a Tobacco smoke.
Keywords
XRCC7, Polymorphism, Acute lymphoblastic leukemia, Susceptibility, Parents smoking statues
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This is a preprint. It has not completed peer review.
Research article
Association between genetic polymorphism of XRCC7 (G6721T) and acute lymphoblastic leukemia risk
zahra beyzaei
Shiraz University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8987-2555
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 18 Dec, 2019
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Medical Genetics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: One of the most important DNA double-strand break (DSBs) repair genes is XRCC7 involved in non-homologous end joining (NHEJ). It is supposed that DNA repair gene malfunction is an important risk factor in various malignancies. The XRCC7 G6721T (rs7003908) polymorphism effect were investigated on the splicing regulation that cause mRNA instability.
Objective: The aim of present hospital-based study was to investigate the association between the G6721T common genetic polymorphism of XRCC7 and risk of acute lymphoblastic leukemia (ALL).
Methods: This case–control study was performed on 99 ALL patients versus 200 healthy blood donors (children), as the control group. Controls had no history of ALL, and they were frequent-matched by age with cases. The polymorphism of XRCC7 was determined using an RFLP-PCR method.
Results: The GT (OR= 1.485, 95% CI: 0.765-2.334, P=0.243) and TT (OR= 1.655, 95% CI: 00.875-3.128, P=0.121) genotypes had no significant effect on risk of ALL, in comparison with the GG genotype. Hence, TT genotype (OR= 1.996, 95% CI: 1.033-3.858, P=0.04) after adjusting for parents smoking pattern showed a significant effect.
Conclusion: The presence of the TT genotype may be increase the risk of ALL in children when facing with a Tobacco smoke.