The fabrication of Conformal Cooling Channels (CCC's) has become easier and more affordable with recent developments in additive manufacturing. The use of CCC's allows for better cooling performance than the conventional (straight drilled) channels, in injection molding. The main reason for this is that the CCC's are able to follow the trajectories of the molded geometry, while the conventional channels made by conventional machining techniques are not able to do so. Some of the parameters that can be significantly improved by using CCC are cooling time, total injection time, uniform temperature distribution, thermal stress and distortion thickness. This article focuses the design optimization of an injection mold, with the aim of optimizing the placement of cooling channels for the minimization of the ejection time and maximization of the uniformity of temperature distribution. In this work, an optimization methodology was developed, with the aim of optimizing the placement of cooling channels in the design stage of the mold, for obtaining pre-optimized molds from a geometric standpoint. It can be concluded that the developed methodology is efficient and useful for the aims of the work.