This experimental study investigated for the effect of laser parameters on machining of the SS41 and SUS304. These materials play an importance role in engineering aspect. They are widely used in high-tech industries such as aerospace, automotive, and semiconductor. Due to the development of technology and high-tech industrialization, the various processing technologies requiring high precision are being developed. However, the conventional cutting process is difficult to meet high precision processing. Therefore, to achieve high precision processing of the SS41 and SUS304, laser manufacturing has been applied. The experiment investigates the process quality of laser cutting for SS41 and SUS304, with the usage of a continuous wave CO2 laser cutting system. The experimental variables are set to the laser cutting speed, laser power, and different used materials. The results are significantly affected by the laser parameters. As the results, the process quality of the laser cutting has been observed by measuring the top and bottom kerf widths, as well as the size of the melting zone and HAZ according to Eline. In addition, the evaluation of the laser processing parameters is significantly important to achieve optimal cutting quality. Therefore, we observed the correlation between the laser parameters and cutting quality. These were evaluated by analysis of variance (ANOVA) and multiple regression analysis.