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Lichen Yang
Chinese Center for Disease Control and Prevention
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2691-0411
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Metabolic syndrome (MetS) is a major public health problem in the world and some studies indicated that it is significantly associated with the future risk of cardiovascular disease. There is also a certain prevalence of Mets in childhood and shows a trend of younger age. Previous studies on the relationship between elements and MetS were mostly seen in adults with single element analysis, and reports on children and the combined effects of multiple elements were very limited. With the data form 2010–2012 China National Nutrition and Health Survey, we aim to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in 6–12-year-old rural Chinese children.
Methods: A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were enrolled. Basic characteristics, metals and MetS component parameters were collected. Multivariate logistic regression analysis was performed to examine the independent relationship between metals and MetS components.
Results: Copper was positively associated with elevated waist (OR=2.00, 1.18–3.28) and negatively associated with elevated TG (OR=0.33, 0.16-0.65). When high Cu combined with Zn, the association with elevated waist and elevated TG both disappeared. In the combination of Cu and Mg, high Cu with high Mg had a positive association with elevated waist (OR=2.03, 1.26-3.27) and high Cu with low Mg had a negative asscoiation with elevated TG (OR=0.40, 0.16-0.95).
Conclusions: Our study suggested that both the single and combined effects of Cu, Mg and Zn were associated with MetS components, especially in elevated waist and TG. And the comprehensive analysis of multiple elements was different from the results of single element analysis, which provide new avenues for the early screening of MetS. Additional research is needed to confirm these findings in other populations.
Keywords
MetS components, whole blood, copper, zinc, magnesium, Chinese children
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CURRENT STATUS: Under Review
Version 1
Posted 02 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 13 Feb, 2021
Review #3 received
Received 12 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewer #3 agreed
On 30 Jan, 2021
Reviewer #2 agreed
On 28 Jan, 2021
Review #1 received
Received 06 Jan, 2021
Reviewer #1 agreed
On 05 Jan, 2021
Reviewers invited
Invitations sent on 28 Oct, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
First submitted
On 25 Oct, 2020
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Nutrition & Metabolism. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Lichen Yang
Chinese Center for Disease Control and Prevention
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2691-0411
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 02 Nov, 2020
No community comments so far
Editorial decision: Major revision
On 13 Feb, 2021
Review #3 received
Received 12 Feb, 2021
Review #2 received
Received 11 Feb, 2021
Reviewer #3 agreed
On 30 Jan, 2021
Reviewer #2 agreed
On 28 Jan, 2021
Review #1 received
Received 06 Jan, 2021
Reviewer #1 agreed
On 05 Jan, 2021
Reviewers invited
Invitations sent on 28 Oct, 2020
Editor assigned
On 27 Oct, 2020
Submission checks complete
On 26 Oct, 2020
Editor invited
On 26 Oct, 2020
First submitted
On 25 Oct, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Metabolic syndrome (MetS) is a major public health problem in the world and some studies indicated that it is significantly associated with the future risk of cardiovascular disease. There is also a certain prevalence of Mets in childhood and shows a trend of younger age. Previous studies on the relationship between elements and MetS were mostly seen in adults with single element analysis, and reports on children and the combined effects of multiple elements were very limited. With the data form 2010–2012 China National Nutrition and Health Survey, we aim to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in 6–12-year-old rural Chinese children.
Methods: A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were enrolled. Basic characteristics, metals and MetS component parameters were collected. Multivariate logistic regression analysis was performed to examine the independent relationship between metals and MetS components.
Results: Copper was positively associated with elevated waist (OR=2.00, 1.18–3.28) and negatively associated with elevated TG (OR=0.33, 0.16-0.65). When high Cu combined with Zn, the association with elevated waist and elevated TG both disappeared. In the combination of Cu and Mg, high Cu with high Mg had a positive association with elevated waist (OR=2.03, 1.26-3.27) and high Cu with low Mg had a negative asscoiation with elevated TG (OR=0.40, 0.16-0.95).
Conclusions: Our study suggested that both the single and combined effects of Cu, Mg and Zn were associated with MetS components, especially in elevated waist and TG. And the comprehensive analysis of multiple elements was different from the results of single element analysis, which provide new avenues for the early screening of MetS. Additional research is needed to confirm these findings in other populations.
Figure 1
Figure 2
Figure 3
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