Blood is useful for assessing the health status, clinical evaluation survey of physiological, pathological conditions and diagnostic and prognostic evaluation of various types of diseases in animals. Blood parameters change in relation to the physiological status of an animal. The analysis of blood indices has proven to be valuable approach for analyzing the health status of animals as these indices provide reliable information on metabolic disorders. The fish, Cyprinus carpio exposed in lethal and sub lethal concentrations of fluoride at varying time intervals and effects on various hematological parameters were evaluated. WBC was decreased significantly in both concentrations. Significantly increased in the percentage of HB% at 96h in lethal & sub lethal, there was significantly decreased RBC level in lethal concentrations. While it was significantly increased RBC level at 48h. In lethal, HCT levels were decreased in all the durations. In sub lethal, HCT levels were insignificantly increased in 96h. In the lethal MCV was significantly decreased in all the duration. In sub lethal, MCV was found highly increased insignificantly. In lethal MCH was highly increased insignificantly in all the duration. While in sub lethal MCH was insignificantly increased in 48h & 72h. In the lethal & sub lethal concentrations of fluoride significantly increased in the MCHC levels.